Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials

Chow, Roberta; Johnson, Mark I.; Lopes-Martins, Rodrigo Álvaro Brandão; Bjordal, Jan Magnus

doi:10.1016/s0140-6736(09)61522-1

Cited by 512 publications

(319 citation statements)

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“…Since 1967, this therapy has been used for several applications in medicine to treat disorders such as inflammation, pain, or accelerate healing [1][2][3]. Light therapy can be delivered by laser diodes, light-emitting diodes (LEDs), or other light sources with specific wavelengths ("colors") [1].…”

Section: Introductionmentioning

confidence: 99%

Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

et al. 2015

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Recently, low-level laser (light) therapy has been used to increase muscle performance in intense exercises. However, there is a lack of understanding of the time response of muscles to light therapy. The first purpose of this study was to determine the time response for light-emitting diode therapy (LEDT)-mediated increase in adenosine triphosphate (ATP) in the soleus and gastrocnemius muscles in mice. Second purpose was to test whether LEDT can increase the resistance of muscles to fatigue during intense exercise. Fifty male Balb/c mice were randomly allocated into two equal groups: LEDT-ATP and LEDT-fatigue. Both groups were subdivided into five equal subgroups: LEDT-sham, LEDT-5 min, LEDT-3 h, LEDT-6 h, and LEDT-24 h. Each subgroup was analyzed for muscle ATP content or fatigue at specified time after LEDT. The fatigue test was performed by mice repeatedly climbing an inclined ladder bearing a load of 150 % of body weight until exhaustion. LEDT used a cluster of LEDs with 20 red (630± 10 nm, 25 mW) and 20 infrared (850±20 nm, 50 mW) delivering 80 mW/cm 2 for 90 s (7.2 J/cm 2 ) applied to legs, gluteus, and lower back muscles. LEDT-6 h was the subgroup with the highest ATP content in soleus and gastrocnemius compared to all subgroups (P<0.001). In addition, mice in LEDT-6 h group performed more repetitions in the fatigue test (P<0.001) compared to all subgroups: LEDT-sham and LEDT-5 min (~600 %), LEDT-3 h (~200 %), and LEDT-24 h (~300 %). A high correlation between the fatigue test repetitions and the ATP content in soleus (r=0.84) and gastrocnemius (r=0.94) muscles was observed. LEDT increased ATP content in muscles and fatigue resistance in mice with a peak at 6 h. Although the time response in mice and humans is not the same, athletes might consider applying LEDT at 6 h before competition.

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Section: Introductionmentioning

confidence: 99%

Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

et al. 2015

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“…5 Although traditionally administered with needles, laser acupuncture (low-intensity laser therapy to acupuncture points) is a noninvasive alternative with evidence of benefit in some pain conditions. [6][7][8] Efficacy of laser acupuncture compared with needles is unknown. Preliminary evidence suggests laser may be superior to needles for myofascial trigger points.…”

mentioning

confidence: 99%

Acupuncture for chronic knee pain: a randomized clinical trial

Hinman¹,

McCrory²,

Pirotta³

et al. 2015

Deutsche Zeitschrift für Akupunktur

124

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IMPORTANCEThere is debate about benefits of acupuncture for knee pain.OBJECTIVE To determine the efficacy of laser and needle acupuncture for chronic knee pain. DESIGN, SETTING, AND PARTICIPANTSZelen-design clinical trial (randomization occurred before informed consent), in Victoria, Australia (February 2010-December 2012. Community volunteers (282 patients aged Ն50 years with chronic knee pain) were treated by family physician acupuncturists. INTERVENTIONSNo acupuncture (control group, n = 71) and needle (n = 70), laser (n = 71), and sham laser (n = 70) acupuncture. Treatments were delivered for 12 weeks. Participants and acupuncturists were blinded to laser and sham laser acupuncture. Control participants were unaware of the trial. RESULTS At 12 weeks and 1 year, 26 (9%) and 50 (18%) participants were lost to follow-up, respectively. Analyses showed neither needle nor laser acupuncture significantly improved pain (mean difference; −0.4 units; 95% CI, −1.2 to 0.4, and −0.1; 95% CI, −0.9 to 0.7, respectively) or function (−1.7; 95% CI, −6.1 to 2.6, and 0.5; 95% CI, −3.4 to 4.4, respectively) compared with sham at 12 weeks. Compared with control, needle and laser acupuncture resulted in modest improvements in pain (−1.1; 95% CI, −1.8 to −0.4, and −0.8; 95% CI, −1.5 to −0.1, respectively) at 12 weeks, but not at 1 year. Needle acupuncture resulted in modest improvement in function compared with control at 12 weeks (−3.9; 95% CI, −7.7 to −0.2) but was not significantly different from sham (−1.7; 95% CI, −6.1 to 2.6) and was not maintained at 1 year. There were no differences for most secondary outcomes and no serious adverse events. MAIN OUTCOMES AND MEASURES CONCLUSIONS AND RELEVANCEIn patients older than 50 years with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function. Our findings do not support acupuncture for these patients.TRIAL REGISTRATION anzctr.org.au Identifier: ACTRN12609001001280 JAMA. 2014;312(13):1313-1322. doi:10.1001/jama.2014 Author Audio Interview at jama.com Related article page 1342Supplemental content at jama.com C hronic knee pain affects many people older than 50 years 1 and is the most common pain concern among older people consulting family physicians. 2 It is typically due to osteoarthritis and associated with declines in physical function. Nonpharmacological approaches are central to managing chronic knee pain. 3,4 Patients with joint pain and arthritis frequently use complementary and alternative medicine. 5 Acupuncture is the most popular of alternative medical systems, with use increasing over time. 5 Although traditionally administered with needles, laser acupuncture (low-intensity laser therapy to acupuncture points) is a noninvasive alternative with evidence of benefit in some pain conditions. 6-8 Efficacy of laser acupuncture compared with needles is unknown. Preliminary evidence suggests laser may be superior to needles for myofascial trigger points. 9 A meta-analysis supports needle acupuncture for osteoart...

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“…Values found for the limb withdrawal threshold (in grams) for the pressure performed on the plantar surface (Plantar) and close to the incision (Local) in the pre-injury (Pre) times, 10 (10') and 60 (60') minutes of awakening. Discussion LLLT is a useful tool for the therapeutic field, aiming tissue repair (Bossini et al, 2012;Cury et al, 2013;Hussein, Alfars, Falih, & Hassan, 2011;Vasilenko et al, 2010), anti-inflammatory effects (Chen, Huang, Sharma, & Hamblin, 2011;Marcos et al, 2011) and analgesia (Chow et al, 2007;Chow, Johnson, Lopes-Martins, & Bjordal, 2009;Chow, Armati, Laakso, Bjordal, & Baxter, 2011;Eslamian, Shakouri, Ghojazadeh, Nobari, & Eftekharsadat, 2012;Rayegani et al, 2011;Yan et al, 2011). However, Aras et al (2010), in a review study, indicate a possible dubious effect of low power laser associated with anesthetics, since it can help or hinder the effects of anesthesia.…”

Section: Evaluation Of Nociceptionmentioning

confidence: 99%

<b>Interaction between low level laser therapy and anesthesia in wistar rats

Rocha

Silva

Meireles

et al. 2016

Acta Sci. Health Sci.

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ABSTRACT. The aim was to assess whether the low level laser therapy (LLLT), 660 nm, can lower the effect of injectable anesthetics in rats. Wistar rats (n = 20) were used in two steps: 1) grip strength test and measuring the anesthesia time for control (G1A) and irradiated (G1AL) groups; 2) after 15 days, rats received new anesthesia injection and were evaluated for nociception (G2A -control; G2AL -laser). Anesthesia was induced by ketamine hydrochloride (75 mg kg ), by intraperitoneal injection, according to the body weight. LLLT used was 660 nm at four sites along the right hind limb. Anesthesia time was shorter for the G1AL (p = 0.0031). There were significant differences between pre-and post-intervention in the grip strength test (p < 0.001), but no differences were detected between groups (p = 0.459). For nociception, G2AL achieved higher values than G2A (p = 0.019 and p = 0.032), and also for the comparison between pre-injury values with the following values (p < 0.001) although no significant difference was found between 10 and 60 minutes (p > 0.05). It can be concluded that the LLLT caused no significant reduction on the effect of anesthesia.Keywords: low-level laser therapy. anesthesia. pain measurement.Interações entre laser de baixa potência e anestesia em ratos wistar RESUMO. O objetivo deste estudo é avaliar se o laser de baixa potência (LBP) pode desempenhar algum efeito na diminuição da ação de anestésicos injetáveis. Foram utilizados 20 ratos Wistar, em duas etapas: 1) realizado teste de força de preensão e contagem de tempo de anestesia para animais controle (G1A) e irradiados (G1AL); 2) após 15 dias, novo procedimento anestésico e avaliada a nocicepção (G2A -controle; G2AL -laser). Foram utilizados os anestésicos Quetamina (75 mg kg -1 ) e Xilazina (10 mg kg -1 ), de acordo com o peso corporal, com injeção intraperitoneal. O laser utilizado foi 660 nm, em 4 locais, ao longo do membro pélvico direito. O tempo cronometrado de anestesia foi menor para G1AL (p = 0,0031). Na avaliação da força de preensão, houve diferenças significativas (p < 0,001) entre o momento pré x pós, mas não entre os grupos (p = 0,459). Para a nocicepção, G2AL obteve valores maiores do que G2A (p = 0,019 e p = 0,032), bem como ao comparar os valores pré-lesão com os seguintes (p < 0,001), mas sem diferenças entre 10 e 60 minutos (p > 0,05). Conclui-se que o LBP não apresentou grandes interações com relação à diminuição do efeito da anestesia.Palavras-chave: terapia a laser de baixa intensidade. anestesia. medição da dor.

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Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials

Cited by 512 publications

References 78 publications

Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

Acupuncture for chronic knee pain: a randomized clinical trial

<b>Interaction between low level laser therapy and anesthesia in wistar rats

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