Efficacy of low‐level laser therapy on hair regrowth in dogs with noninflammatory alopecia: a pilot study

Olivieri, Lara; Cavina, Damiano; Radicchi, Giada; Miragliotta, Vincenzo; Abramo, Francesca

doi:10.1111/vde.12170

Cited by 28 publications

(25 citation statements)

References 17 publications

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“…For this reason, using LILT as alternative treatment for wound healing will be beneficial because LILT both reduces pain and enhances the wound healing. In addition, the positive effects of LILT in companion animals have been demonstrated for canine osteoarthritis [ 4 ], for stimulating hair regrowth in dogs with non-inflammatory alopecia [ 10 ], and for the treatment of pyogranulomatous pododermatitis in dogs [ 11 ]. However, several studies in veterinary medicine have not shown any beneficial outcomes.…”

Section: Introductionmentioning

confidence: 99%

Penetration depth study of 830 nm low-intensity laser therapy on living dog tissue

et al. 2020

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Background and Aim: Recent studies have shown that low-intensity laser therapy (LILT) enhances chronic wound healing, reduces pain, reduces inflammation, and improves post-operative rehabilitation. However, clinical outcomes in the veterinary use of LILT vary between different experimental studies. This is explained by improper laser parameter settings and limits of its penetration depth. This study aimed to investigate the penetration depth of 830 nm LILT on living dog tissue in different operating modes. This entailed continuous wave (CW) versus pulse wave (PW) and with contact versus non-contact techniques of the laser probe at different tissue-laser probe distances. The results can be applied for use in clinical practice. Materials and Methods: Twenty-four dogs that had undergone abdominal surgery were included in this study. The laser parameters were set at 200 mW, fluence of 4 J/cm2 and the laser power output denoted as mean output power (MOP) was measured by a power meter. Results: The MOP of the 830 nm CW laser was significantly higher than the PW laser (p<0.05). The MOP of the contact technique was significantly greater than that of the non-contact technique in both CW and PW modes (p<0.05). The MOP through the skin tissue was between 16.09 and 18.60 mW (8.05-9.30%) for the contact technique and 8.73 and 19.36 mW (4.37-9.68%) for the non-contact technique. In the muscle-skin layer, the MOP was between 0.50 and 1.56 mW (0.25-0.78%) and the MOP was not detected using the non-contact technique with a 5 cm tissue-laser probe distance. Conclusion: Our study indicates that 830 nm LILT (with laser parameter setting at 200 mW, fluence of 4 J/cm2 for both contact and non-contact techniques, and tissue-laser probe distance up to 5 cm) was appropriate for treatments within 14 mm of depth. However, the use of 830 nm LILT for an application in which the target tissue is deeper than 14 mm may limit its positive effect.

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Section: Introductionmentioning

confidence: 99%

Penetration depth study of 830 nm low-intensity laser therapy on living dog tissue

et al. 2020

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“…The beneficial effect of visible light on hair loss was first reported by Mester et al [9]. Low level visible light, especially light in the red spectrum, is proposed as a potential treatment for hair loss, especially for nonscarring alopecia [10][11][12][13][14][15][16][17][18][19][20]. Though increased local blood flow and paracrine growth factors from the dermal papilla are speculated as possible mechanisms of hair growth [21,22], how visible light in different spectrum regulates hair follicle physiology is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro

et al. 2014

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“…[ 16 ], on a single subject, for the treatment of a chronic non-surgical wound and that by Olivieri et al . [ 26 ] for the treatment of non-inflammatory alopecia in seven dogs, both with a favorable outcome. It is, therefore, very difficult to compare our data with those reported in the literature, where veterinary studies are almost exclusively animal models for human medicine.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we designed our study as a pilot study of a clinical innovative therapy on a small number of subjects following the literature on some similar studies on new treatments in dermatology [ 26 , 32 , 33 ]. We preferred to use the “case-control” study design on the same subject to reduce the variables of clinical response and avoid confounding factors such as age, race, and gender.…”

Section: Discussionmentioning

confidence: 99%

Low-level laser therapy: Case-control study in dogs with sterile pyogranulomatous pododermatitis

Perego¹,

Proverbio²,

Zuccaro³

et al. 2016

Vet World

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Aim:Low-level laser therapy (LLLT) is a therapeutic photobiostimulation with properties in reducing swelling, inflammation, and promoting tissue healing. The objective of this pilot study was to evaluate LLLT in sterile pyogranulomatous pododermatitis in five dogs.Materials and Methods:In each dog, one lesion was designated as the control (treated with a 0.0584% hydrocortisone aceponate spray), and one or more other lesions were treated with a gallium aluminum arsenide-laser, daily for 5 days. Lesions were scored before treatment (D0), at the end (D4), 16 days after the last laser treatment (D20), and after 2 months (D65).Results:Comparing the treated lesion group with the control lesion group, the clinical score was similar at D0, whereas there was a statistically significant difference at D4 and D20; in the treated group over time, there was a statistically significant improvement between D0, D4, and D20. Lesion recurrence was absent in more than 50% of the treated lesions at D65. No adverse reactions were reported.Conclusion:Given the positive results of this first clinical study, it would be interesting to extend the study to confirm the validity of this type of therapy in sterile pyogranulomatous pododermatitis in the dog.

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Efficacy of low‐level laser therapy on hair regrowth in dogs with noninflammatory alopecia: a pilot study

Abstract: Our clinical and histological data document promising effects of LLLT on hair regrowth in CNA. Further studies investigating the biological mechanism underlying the effect of LLLT on hair follicle cycling are warranted.

Cited by 28 publications

References 17 publications

Penetration depth study of 830 nm low-intensity laser therapy on living dog tissue

Penetration depth study of 830 nm low-intensity laser therapy on living dog tissue

Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro

Low-level laser therapy: Case-control study in dogs with sterile pyogranulomatous pododermatitis

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