Efficacy of low‐level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review

Akram, Zohaib; Abduljabbar, Tariq; Vohra, Fahim; Javed, Fawad

doi:10.1111/jop.12619

Cited by 53 publications

(31 citation statements)

References 31 publications

(166 reference statements)

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“…The investigators used PBM therapy (940 nm diode laser, twice weekly for 2 months) and noted reduction in VAS scores (0% at 2 months), and no recurrences over a 7‐month follow‐up period. Two recent systematic reviews nicely summarize the clinical evidence, and their analyses indicate the use of PBM therapy in OLP remains equivocal, suggesting a need for better controlled randomized clinical trials (Akram, Abduljabbar, Vohra, & Javed, ; Al‐Maweri et al., ).…”

Section: Photobiomodulation Therapy In Oral Diseasesmentioning

confidence: 99%

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

et al. 2018

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This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

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Section: Photobiomodulation Therapy In Oral Diseasesmentioning

confidence: 99%

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

et al. 2018

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“…The pathogenesis of this dermatosis is complicated and currently not clearly understood [8][9][10] . Accordingly, numerous studies are conducted to identify the major links in its pathogenesis, including those devoted to the combined effect of hereditary, neuroendocrine, immune and metabolic factors [11][12][13][14] . A number of authors insist on the role of endogenous intoxication (EI), which is considered a nonspecific syndrome occurring due to increased tissue decomposition, insufficient processes of endogenous toxin inactivation 15,16 .…”

Section: Introductionmentioning

confidence: 99%

The role of homocysteine and other endogenous intoxication markers in the pathogenesis of lichen planus

Melnyk¹,

BONDAR²

2019

Arch Balk Med Union

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Étude du rôle de l'homocystéine et d'autres marqueurs de l'intoxication endogène dans la pathogenèse du développement du lichen planIntroduction. Le lichen plan (LP) est une dermatose poly-étiologique chronique selon son mécanisme d'apparition qui se manifeste par une éruption papuleuse sur la peau et les muqueuses, ainsi que par des démangeaisons intenses. L'objectif de cette étude est d'identifier et d'analyser le niveau de marqueurs d'intoxication endogène dans le plasma sanguin de patients atteints de lichen plan selon la gravité et la durée de la maladie. Matériaux et méthodes. Nous avons surveillé 48 patients atteints de LP: 20 hommes et 28 femmes. Chez 31 patients, la dermatose a duré moins de 2 ans, chez 17 patients -plus de 2 ans. Un faible degré de LP a été diagnostiqué chez 17 patients, un moyen -chez 31. On a déterminé dans le sang de tous les patients les taux de l'homocystéine (Hcy), des carbonyles des protéines modifiées par oxydation (C-PMO) et des peptides d'un poids moléculaire moyen (PPMM). ABSTRACTIntroduction. Lichen planus (LP) is a chronic poly-etiologic dermatosis by the mechanism of its development, manifested by papular rash on the skin and mucous membranes, severe itching. The objective of the study was to determine and analyze the levels of endogenous intoxication markers in blood plasma of the patients with lichen planus depending on severity and duration of the disease. Materials and methods. 48 patients, 20 men and 28 women, participated in the study. 31 patients had suffered from dermatosis for about 2 years, and 17 patients for over 2 years. Mild LP was diagnosed in 17 patients and moderate LP in 31 patients. The blood levels of homocysteine (HC), carbonyl groups of oxidative modified proteins (CG-OMP) and medium molecular weight peptides (MMWP) were determined in all the patients. Results. Significantly increased blood plasma levels of HC, MMWP and CG were found in patients with lichen planus as compared to the control group. The patients with severe and prolonged course of dermatosis had more evident disturbances in the content

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“…Low-intensity laser therapy (LILT) in dentistry has been used for longer than half a century and has enabled clinicians to achieve enhanced clinical results in the treatment of several oral diseases, including periodontal diseases, desquamative gingivitis, pigmented lesions, and GR defects. [6][7][8][9][10][11][12][13] Research indicates that LILT produces tissue surface sterilization and minimizes the chances of bacteremia, and decreases edema, swelling, and scarring. 14 In addition, LILT has been shown to successfully biostimulate and accelerate wound healing by stimulating epithelization and regeneration of human and animal tissue.…”

Section: Introductionmentioning

confidence: 99%

Low‐intensity laser for harvesting palatal graft for the treatment of gingival recession: A systematic review

Al‐Shibani

2018

J of Invest & Clin Dent

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The aim of the present study was to assess the efficacy of low‐intensity laser therapy (LILT) for harvesting palatal connective tissue graft (PCTG) in the treatment of gingival recession. Databases were searched up to May 2018. The addressed focused question was: Is adjunctive LILT effective in the healing of donor palatine area after harvesting PCTG? Screening of the initially identified studies resulted in four clinical studies. All studies showed that LILT was effective in improving clinical outcomes, such as tissue thickness, postoperative discomfort, remaining wound area, and visual analog score at follow up. Upon comparison with the control group, two studies showed significantly greater improvements in the clinical parameters and patient‐centered outcomes for LILT than control groups at follow up. Due to the low number of included clinical studies, it remains debatable whether LILT improves clinical and patient‐centered outcomes of PCTG procedures. Further randomized controlled trials are needed to evaluate the outcomes of LILT on the healing of donor palatine area after harvesting PCTG

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Efficacy of low‐level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review

Abstract: It remains debatable whether LLLT is more effective as compared to corticosteroids in the treatment of OLP, given that the scientific evidence is weak. These findings are preliminary and further randomized clinical trials are recommended.

Cited by 53 publications

References 31 publications

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

The role of homocysteine and other endogenous intoxication markers in the pathogenesis of lichen planus

Low‐intensity laser for harvesting palatal graft for the treatment of gingival recession: A systematic review

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