Efficacy of Low Reactive-Level Laser Therapy for Pain Attenuation of Postherpetic Neuralgia

Kemmotsu, Osamu; Sato, Kenichi; Furumido, Hitoshi; Harada, Koji; Takigawa, Chizuko; Kaseno, Shigeo; Yokota, Sho; Hanaoka, Yukari; Yamamura, Takeyasu

doi:10.5978/islsm.91-or-10

Cited by 64 publications

(27 citation statements)

References 6 publications

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“…5 Other neuropathic pain conditions such as trigeminal neuralgia, 10 which has been successfully treated by LLLT (830 nm) applied to the face, 10 and post-herpetic neuralgia, in which the affected dermatome is treated. [6][7][8] We suggest that for the maximum inhibitory effect on pain fibers, LI should be applied over an area of pathology, treating tender points in the related dermatome, myotome and sclerotome. This method would support the use of laser cluster heads for LLLT, rather than single laser diodes, to achieve more efficient coverage of an area of pathology.…”

Section: Discussionmentioning

confidence: 99%

“…A recent review of these effects on peripheral mammalian nerves in human studies demonstrated that transcutaneous infrared (IR) LI applied overlying the course of nerves increased compound action potential (CAP) latencies in median, sural, and superficial radial nerves [2][3][4] , causing conduction block. This finding is particularly relevant to low-level laser therapy (LLLT) in neuropathic pain conditions such as carpal tunnel syndrome, 5 post-herpetic neuralgia, [6][7][8] sciatica, 9 and trigeminal neuralgia, 10 in which LI is applied over the course of the nerves and to their peripheral endings, specifically to relieve pain. In laser acupuncture (LA), also used in the treatment of painful conditions, LI is applied transcutaneously to a single, anatomically defined acupuncture point, many of which overlie the course of peripheral nerves.…”

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confidence: 99%

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Electrophysiological Effects of Single Point Transcutaneous 650 and 808 nm Laser Irradiation of Rat Sciatic Nerve: A Study of Relevance for Low-Level Laser Therapy and Laser Acupuncture

Chow

Yan²,

Armati³

2012

Photomedicine and Laser Surgery

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Objective: The purpose of this study was to evaluate effects of transcutaneous 650 and 808 nm laser irradiation (LI) to a single point overlying rat sciatic nerve; a comparison to four point LI and relevance to the clinical application of low-level laser therapy (LLLT) and laser acupuncture (LA). Background data: Transcutaneous LI inhibits somatosensory and motor conduction when delivered to four points overlying sciatic nerve; however, effects of the same total energy delivered to a single point over the nerve, equating to laser acupuncture, are undefined. Methods: Transcutaneous 808 nm, 450 mW, (13.5 or 54 J) continuous wave (cw) mode or 650 nm, 35 mW, (1.1 or 4.4 J), cw LI or sham LI, was applied for 30 or 120 sec to a single point overlying the midpoint of rat sciatic nerve. Somatosensory evoked potentials (SSEPs) and compound muscle action potentials (CMAPs) were then recorded after 10 and 20 min, and after 24 and 48 h. Results: 120 sec of 808 nm LI increased SSEP amplitudes only at 10 min, with no effect of 30 or 120 sec at other time points on SSEPs or on CMAPs. LI 650 nm for 30 or 120 sec did not alter SSEPs or CMAPs at any time point. Conclusions: Localized transcutaneous 808 LI to a single point overlying sciatic nerve increases SSEP amplitudes when compared with delivery of the same total energy to four points, which causes decreased SSEP amplitudes and conduction block. Therefore, the area and duration of delivery are important, independent variables with implications for clinical delivery of both LLLT and LA.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Electrophysiological Effects of Single Point Transcutaneous 650 and 808 nm Laser Irradiation of Rat Sciatic Nerve: A Study of Relevance for Low-Level Laser Therapy and Laser Acupuncture

Chow

Yan²,

Armati³

2012

Photomedicine and Laser Surgery

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“…For over two decades, photoradiation has been used to treat pain associated with musculo-skeletal injuries, arthritic conditions, and postherpetic neuralgia, to name a few. [18][19][20][21][22][23] Some mechanisms underlying therapeutic effects with photoradiation have been reviewed elsewhere [24][25][26] and include the following: (1) increased adenosine triphosphate (ATP) production by the mitochondria 27 and increased oxygen consumption on the cellular level 28 ; (2) increased serotonin 29 and increased endorphins (naloxone has been observed to block the analgesic effect of photoradiation with GaAlAs laser) 30 ; and (3) anti-inflammatory effects. 31,32 The primary effects are photobiologic, rather than photothermal.…”

Section: Naesermentioning

confidence: 99%

Photobiomodulation of Pain in Carpal Tunnel Syndrome: Review of Seven Laser Therapy Studies

Naeser

2006

Photomedicine and Laser Surgery

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In this review, seven studies using photoradiation to treat carpal tunnel syndrome (CTS) are discussed: two controlled studies that observed real laser to have a better effect than sham laser, to treat CTS; three openprotocol studies that observed real laser to have a beneficial effect to treat CTS; and two studies that did not observe real laser to have a better effect than a control condition, to treat CTS. In the five studies that observed beneficial effect from real laser, higher laser dosages (9 Joules, 12-30 Joules, 32 J/cm 2 , 225 J/cm 2 ) were used at the primary treatment sites (median nerve at the wrist, or cervical neck area), than dosages in the two studies where real laser was not observed to have a better effect than a control condition (1.8 Joules or 6 J/cm 2 ). The average success rate across the first five studies was 84% (SD, 8.9; total hands = 171). The average pain duration prior to successful photoradiation was 2 years. Photoradiation is a promising new, conservative treatment for mild/moderate CTS cases (motor latency < 7 msec; needle EMG, normal). It is cost-effective compared to current treatments.

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“…The condition usually regresses spontaneously within 1-6 months but can persist for many years. 3,4) The treatment protocol for PHN is initiated with antiviral drugs during the acute herpes zoster outbreak. Other treatment options for PHN include topical analgesics, opioid analgesics, tricyclic antidepressants, gabapentin, cutaneous stimulation, injection therapy, acupuncture and hypnotherapy.…”

Section: Introductionmentioning

confidence: 99%

Low Reactive Level Laser Therapy in the Treatment of Post Herpetic Neuralgia

Sasaki¹,

Ohshiro²,

Ohshiro³

et al. 2010

LASER THERAPY

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Post herpetic neuralgia (PHN) can be an extremely painful condition which in many cases proves resistant to all the accepted forms of treatment. It is frequently most severe in the elderly and may persist for years with no predictable course. Since 1980, we have been applying low reactive level laser therapy (LLLT) for patients with PHN. We report herein on the results of a retrospective study concerning those patients in whom LLLT has been applied for pain attenuation of PHN. One hundred and twenty-three patients (73 male, 50 female, mean age: 66.11yr) have received LLLT for various entities of PHN over the past 29 years. In these cases the affected tissue area(s) was as follows: thorax and back (48 cases); head and neck (41 cases); abdomen and lumbar (17 cases); upper limb (9 cases); and lower limb (8 cases). The overall total improvement rate was 60.16%. Patient whose treatment was given within six month of onset obtained the highest improvement rate (mean, 76.34%). LLLT was effective for PHN in the acute and chronic phase, but LLLT was particularly effective for the acute phase patients whose onset before treatment was 6 months or less. The results demonstrate a significant reduction in PHN pain intensity, hypersensitivity and other complaints

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Efficacy of Low Reactive-Level Laser Therapy for Pain Attenuation of Postherpetic Neuralgia

Cited by 64 publications

References 6 publications

Electrophysiological Effects of Single Point Transcutaneous 650 and 808 nm Laser Irradiation of Rat Sciatic Nerve: A Study of Relevance for Low-Level Laser Therapy and Laser Acupuncture

Electrophysiological Effects of Single Point Transcutaneous 650 and 808 nm Laser Irradiation of Rat Sciatic Nerve: A Study of Relevance for Low-Level Laser Therapy and Laser Acupuncture

Photobiomodulation of Pain in Carpal Tunnel Syndrome: Review of Seven Laser Therapy Studies

Low Reactive Level Laser Therapy in the Treatment of Post Herpetic Neuralgia

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