Efficacy of lycopene for management of oral potentially malignant disorders: A systematic review and meta-analysis

Al‐Maweri, Sadeq Ali; Halboub, Esam; Al-Qadhi, Gamilah; Al-Wesabi, Mohammed; Al-Sharani, Hesham Mohammed; Parveen, Sameena; Alhashimi, Najah; Almeslet, Asma; Alhajj, Mohammed Nasser

doi:10.1016/j.oooo.2022.08.004

Cited by 5 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 30 The management of OPMDs includes pharmacological therapy, surgical excision, or combination of both. 31 …”

Section: Clinical Application Of Pc In Chronic Oral Mucosal Diseasesmentioning

confidence: 99%

Regenerative potential of platelet concentrates in chronic oral mucosal lesions

Hijazi,

Al-Hamed,

Tamimi

et al. 2024

Journal of Oral Biology and Craniofacial Research

Self Cite

View full text Add to dashboard Cite

“… 30 The management of OPMDs includes pharmacological therapy, surgical excision, or combination of both. 31 …”

Section: Clinical Application Of Pc In Chronic Oral Mucosal Diseasesmentioning

confidence: 99%

Regenerative potential of platelet concentrates in chronic oral mucosal lesions

Hijazi,

Al-Hamed,

Tamimi

et al. 2024

Journal of Oral Biology and Craniofacial Research

Self Cite

View full text Add to dashboard Cite

“…OPMDs encompass different disorders, with oral leukoplakia (OL) being the most common [ 3 ], with an estimated annual malignant transformation rate of 10% [ 4 ]. Despite different technological advances in the medical sciences, is still not possible to predict which OPMD will progress into cancer [ 5 , 6 ], with clinicians and pathologists still relying on the same histopathological and clinical indicators used for the last 40 years. There are also significant challenges for diagnosing oral cancer in early stages.…”

Section: Introductionmentioning

confidence: 99%

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Bastías,

Maturana,

Marín

et al. 2024

IJMS

View full text Add to dashboard Cite

Different efforts have been made to find better and less invasive methods for the diagnosis and prediction of oral cancer, such as the study of saliva as a source of biomarkers. The aim of this study was to perform a scoping review about salivary molecules that have been assessed as possible biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC). A search was conducted using EBSCO, PubMed (MEDLINE), Scopus, and Web of Science. The research question was as follows: which molecules present in saliva have utility to be used as biomarkers for the early detection of oral cancer? Sixty-two studies were included. Over 100 molecules were assessed. Most of the markers were oriented towards the early diagnosis of OSCC and were classified based on their ability for detecting OSCC and oral potentially malignant disorders (OPMDs), OSCC outcome prediction, and the prediction of the malignant transformation of OPMDs. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 were the most studied, with almost all studies reporting high sensitivity and specificity values. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 are the most promising salivary biomarkers. However, more studies with larger cohorts are needed before translating the use of these biomarkers to clinical settings.

show abstract

“…In fact, there are recent works that support it. 7,8 Aloe vera, due to its high concentration of antioxidants, helps neutralize free radicals and has been used to alleviate symptoms or prevent diseases related to oxidative stress. 9,10 Curcumin is a plant phenol widely used as a spice (in curry) and food coloring agent.…”

Section: Introductionmentioning

confidence: 99%

“…It is a safe and reliable drug used as a first‐line treatment in the initial management of OSMF, and other premalignant pathologies. In fact, there are recent works that support it 7,8 . Aloe vera, due to its high concentration of antioxidants, helps neutralize free radicals and has been used to alleviate symptoms or prevent diseases related to oxidative stress 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant treatments in patients with oral submucous fibrosis: A systematic review

Pérez‐Leal,

Lanciano,

Flacco

et al. 2023

J Oral Pathology Medicine

View full text Add to dashboard Cite

IntroductionOral submucous fibrosis (OSMF) is a well‐known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high‐risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF.Materials and MethodsThe study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to “antioxidant treatment,” “burning sensation,” and “mouth opening.” The quality assessment of controlled clinical studies adhered to Cochrane guidelines.ResultsThe analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.ConclusionAntioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.

show abstract

Efficacy of lycopene for management of oral potentially malignant disorders: A systematic review and meta-analysis

Cited by 5 publications

References 48 publications

Regenerative potential of platelet concentrates in chronic oral mucosal lesions

Regenerative potential of platelet concentrates in chronic oral mucosal lesions

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Antioxidant treatments in patients with oral submucous fibrosis: A systematic review

Contact Info

Product

Resources

About