Efficacy of Massive Dose Oral Gentamicin Therapy in Nonbloody Persistent Diarrhea with Associated Malnutrition

Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: Experience with Rifaximin

“…On the other hand, the difficulty in identifying the specific bacterial population and the affected part of the digestive tract by SIBO prevents the possibility of using targeted antibiotics; the recommendation is to use a broad-spectrum antibiotic therapy, capable of eradicating aerobes and anaerobes, preferably with a topical rather than a general action. Valuable alternatives to Rifaximin that have been proven to be effective in the treatment of SIBO are norfloxacin and amoxicillinclavulanic acid [21] , levofloxacin and/or metronidazole [22] , gentamycin [23] , trimethoprim/sulfamerazine and polymyxin [24] , and chlortetracycline [18] .…”

Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: An observation on non-absorbable antibiotics

“…It should be noted that further treatment with ciprofloxacin -an antibiotic widely used in the treatment of IBS [52,53] has not given significantly better results than rifaximin in our experience. Valuable alternatives to rifaximin that have been proven to be effective in the treatment of SIBO are represented by norfloxacin and amoxicillin-clavulanic acid [54] , gentamycin [55] , trimethoprim/sulfamerazin and polymyxin [56] , and chlortetracycline [57] .…”

Persistent diarrhea

“…Em estudo caso-controle na África do Sul, usando gentamicina oral, metronidazol e colestiramina em pacientes com diarréia persistente, o uso de gentamicina oral mostrou significante decréscimo nas perdas fecais, não ocorrendo o mesmo com metronidazol 67 . Esse resultado não foi confirmado em estudos posteriores realizados na Guatemala 68 e na Índia 69 . Bahl e cols., em 1996, não encontraram efeito benéfico no uso de metronidazol em diarréia persistente não disentérica e não associada à giardíase ou amebíase 70 .…”