Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: A randomized double-blind placebo-controlled clinical trial

Khonche, Ahmad; Huseini, H Fallah; Abdi, Hossein; Mohtashami, Reza; Nabati, Farzaneh; Kianbakht, S

doi:10.1016/j.jep.2017.05.026

Cited by 22 publications

(15 citation statements)

References 29 publications

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“…ey found that Mentha pulegium extract can significantly decrease total dyspepsia score, and some symptoms, including upper abdominal dull ache, bloating, belching, and stomach pain, compared to the placebo. Moreover, no significant change was observed in other symptom scores in the extract group [21]. Evidence-Based Complementary and Alternative Medicine…”

Section: Discussionmentioning

confidence: 81%

Evaluation of the Effectiveness of Cinnamon Oil Soft Capsule in Patients with Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Zobeiri

Parvizi

Shahpiri

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Different effects of cinnamon and its oil in traditional medicine in the treatment of diseases, including gastrointestinal diseases, were reported. The aim of this study is to evaluate the efficacy and safety of cinnamon oil (Cinnamomum zeylanicum) in patients with functional dyspepsia in a double-blind, randomized placebo-controlled trial. Methods. Soft gelatin capsule was made using the rotary die process, and the final capsule was standardized based on its cinnamaldehyde amount and analyzed by high-performance liquid chromatography (HPLC) method. Sixty-four patients with symptomatic functional dyspepsia were randomized to receive cinnamon oil soft capsule (n = 29) or sesame oil soft capsule as placebo (n = 35) for 6 weeks. The primary efficacy variable was the sum score of the patient’s gastrointestinal symptom (five‐point scale). Secondary variables were the scores of each dyspeptic symptom including severity of vomiting, sickness, nausea, bloating, abdominal cramps, early satiety, acidic eructation/heartburn, loss of appetite, retrosternal discomfort, and epigastric pain/upper abdominal pain, as well as any reported adverse events. Results. The results showed that, after 6 weeks of treatment, the cinnamon oil and placebo groups significantly decreased the total dyspepsia score compared to the baseline at the endpoint ( P < 0.001 ). However, there was no significant difference between the cinnamon oil and placebo groups in terms of the baseline and endpoint values of the outcome variables ( P = 0.317 and P = 0.174 , respectively). Two patients in the cinnamon oil group complained of rashes, and three patients in the placebo group complained of nausea. Conclusion. This study showed significant improvements in gastrointestinal symptom score in both treatment and placebo groups. However, there was no significant difference between the cinnamon oil and sesame oil groups in terms of the baseline and endpoint values of the outcome variables. This study was registered as https://clinicaltrials.gov/ct2/show/IRCT20170802035460N2, 29 December 2017, in the Iranian Registry of Clinical Trials with https://www.IRCT.ir.

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Section: Discussionmentioning

confidence: 81%

Evaluation of the Effectiveness of Cinnamon Oil Soft Capsule in Patients with Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Zobeiri

Parvizi

Shahpiri

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…The results of the in vivo study showed that the aqueous-ethanol extract of A. wilhelmsii exhibited an inhibitory effect on gastric acid output in basal conditions via the gastric parasympathetic nerve. The extract had no effect on vagal-stimulated conditions [46]. Further studies are needed to identify the compounds and mechanisms responsible for this activity.…”

Section: Inhibitory Effect On Gastric Acid Outputmentioning

confidence: 88%

“…Niazmand et al (2010) [46] studied the effects of the aqueous-ethanolic extract obtained by aerial parts of the plant Achillea wilhelmsii on rat's gastric acid output in basal, vagotomized, and vagal-stimulated conditions. The plant samples were collected from South Khorasan province, Iran.…”

Section: Inhibitory Effect On Gastric Acid Outputmentioning

confidence: 99%

Iranian Medicinal Plants: From Ethnomedicine to Actual Studies

et al. 2020

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Iran has a rich and diverse cultural heritage, consisting of a complex traditional medicine deeply rooted in the history of the territory that goes back to the Assyrian and Babylonian civilizations. The ethnomedical practices that can be identifiable nowadays derive from the experience of local people who have developed remedies against a wide range of diseases handing down the knowledge from generation to generation over the millennia. Traditional medicine practices represent an important source of inspiration in the process of the development of new drugs and therapeutic strategies. In this context, it is useful to determine the state of the art of ethnomedical studies, concerning the Iranian territory, and of scientific studies on plants used in traditional Iranian medicine. Data regarding 245 plants used in Iranian ethnomedical practices and scientific studies conducted on 89 plants collected in the Iranian territory have been reported. All of the scientific studies here reported draw inspiration from traditional medicine. The World Health Organization (WHO) has repeatedly called for an intensification of the scientific validation processes of traditional medicines intended as an important contribution to public health in various parts of the world. The process of study and validation of Iranian ethnomedical practices appears to be at an early stage.

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“…There is accumulating evidence that distinct subgroups of uninvestigated dyspepsia exist in the general population, suggesting the requirement for separate evaluation and treatment strategies [3, 4]. Treatments for FD include acid suppressing medicines (proton pump inhibitors), Selective Serotonin re-uptake inhibitors (SSRIs) and drugs affecting gastric motility such as domperidone and mosapride [5]. Medicinal plant preparations have gained increasing attention in the treatment of FD due to their potential health benefits and safety [5–7].…”

Section: Introductionmentioning

confidence: 99%

“…Treatments for FD include acid suppressing medicines (proton pump inhibitors), Selective Serotonin re-uptake inhibitors (SSRIs) and drugs affecting gastric motility such as domperidone and mosapride [5]. Medicinal plant preparations have gained increasing attention in the treatment of FD due to their potential health benefits and safety [5–7]. Most of the herbal remedies for treating FD symptoms worldwide are combinations of several medicinal plants [8].…”

Section: Introductionmentioning

confidence: 99%

Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying

Illuri¹,

Venkataramana²,

Daguet³

et al. 2019

BMC Complement Altern Med

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Background Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal formulations have gained attention to treat the symptoms of functional dyspepsia. We have investigated the safety and efficacy of a novel formulation of Ferula asafoetida oleo resin and standardized Silybum marianum extract (Asdamarin). Methods The effect of asdamarin on delayed gastric emptying was investigated in Sprague Dawley rats using phenol red method. The acute and sub-acute oral toxicity was evaluated in wistar rats following OECD guidelines 425 and 407 respectively. The data were analyzed by one-way ANOVA using GraphPad Prism 5.0 software. Results Oral administration of Asdamarin dose-dependently improved the delay in gastric emptying as evident from the significant increase in the gastrointestinal transit time ( p < 0.001). The LD50 of asdamarin was estimated to be more than 2000 mg/kg. Further, in the 28-day sub-acute toxicity study, the administration of 250, 500 and 1000 mg/kg of Asdamarin did not significantly altered the feed and water consuption, body weight change, biochemical and haematological parameters compared to control animals. Macroscopic and histopathological examination of vital organs revealed no toxic signs. Conclusion The preliminary data from the present study provides the first evidence on the possible effectiveness of novel formulation of F . Asafoatida and S. marianum extracts in alleviating the associated symptoms of functional dyspepsia. The toxicity data indicated that Asdamarin can be considered safe up to 1000 mg/kg dose.

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Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: A randomized double-blind placebo-controlled clinical trial

Cited by 22 publications

References 29 publications

Evaluation of the Effectiveness of Cinnamon Oil Soft Capsule in Patients with Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Evaluation of the Effectiveness of Cinnamon Oil Soft Capsule in Patients with Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Iranian Medicinal Plants: From Ethnomedicine to Actual Studies

Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying

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