Efficacy of Methylene Blue and Aliminium Phthalocyanine Mediated Sonophotodynamic Therapy on Prostate Cancer Cell Lines

Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

“…The methylene blue showed higher cytotoxicity compared to the Pcs. 67 Pc 16 – SDT 3 MHz, 1.0–3.0 W/cm 2 , 60 s Colon-26 cells In vitro and in vivo Bleomycin improve SDT cytotoxicity of the Pcs. An increase in caspase-3/7 observed for bleomycin-Pc-SDT.…”

“…This effect is not yet clear. The sulfonated symmetrical AlS 4 Pc (Pc 15 ) and asymmetrical AlS 2 Pc (Pc 16 ) have been studied and have shown good SDT activities respectively 66 , 67 , 68 . Reduced symmetry of the Pcs structures is achieved by varying the number or type of R-groups on the Pcs structure 69 .…”