Efficacy of model-based iterative reconstruction in cystic fibrosis assessment using CT

Lin, Sandra; Lin, Monica; Lau, Kenneth

doi:10.1016/j.crad.2019.03.009

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…This has led to the exploration of other methods for measuring lung volumes, including plain chest radiographs,10–12 CT,13–15 MRI14 and chest wall kinematics 16. However, plain chest radiographs cannot measure lung volume subdivisions; although thoracic CT is capable of calculating accurate lung volumes,17 it confers an increased radiation dose18 19 and requires non-physiological supine positioning; MRI is time-consuming and difficult to acquire in claustrophobic or dyspnoeic individuals. Chest wall kinematics can reliably estimate lung volumes3 but is impractical for routine use.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study

et al. 2023

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IntroductionDynamic chest radiography (DCR) is a novel, low-dose, real-time digital imaging system where software identifies moving thoracic structures and can automatically calculate lung areas. In an observational, prospective, non-controlled, single-centre pilot study, we compared it with whole-body plethysmography (WBP) in the measurement of lung volume subdivisions in people with cystic fibrosis (pwCF).MethodsLung volume subdivisions were estimated by DCR using projected lung area (PLA) during deep inspiration, tidal breathing and full expiration, and compared with same-day WBP in 20 adult pwCF attending routine review. Linear regression models to predict lung volumes from PLA were developed.ResultsTotal lung area (PLA at maximum inspiration) correlated with total lung capacity (TLC) (r=0.78, p<0.001), functional residual lung area with functional residual capacity (FRC) (r=0.91, p<0.001), residual lung area with residual volume (RV) (r=0.82, p=0.001) and inspiratory lung area with inspiratory capacity (r=0.72, p=0.001). Despite the small sample size, accurate models were developed for predicting TLC, RV and FRC.ConclusionDCR is a promising new technology that can be used to estimate lung volume subdivisions. Plausible correlations between plethysmographic lung volumes and DCR lung areas were identified. Further studies are needed to build on this exploratory work in both pwCF and individuals without CF.Trial registration numberISRCTN64994816.

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Section: Introductionmentioning

confidence: 99%

Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study

et al. 2023

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“…In this series of reviews, Vliegenthart et al outline the latest radiation dose techniques, such as iterative reconstruction and deep learning image reconstruction techniques that can transform 'noisy' ultra-low dose images into high quality images. 4 These techniques have already allowed CT imaging of cystic fibrosis and lung nodules at radiation doses comparable to plain radiography, 5,6 establishing the basis to make significant inroads into lung cancer screening. In this imaging series, the authors provide an account of the photon-counting detector CT-the nextgeneration CT technology that results in higher contrast-tonoise ratio, higher spatial resolution, at a lower radiation dose and with reduction of noise and artefacts.…”

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confidence: 99%