Efficacy of mu‐opioid agonists in the treatment of evoked neuropathic pain: Systematic review of randomized controlled trials

Eisenberg, Elon; McNicol, Ewan D; Carr, Daniel B.

doi:10.1016/j.ejpain.2005.10.007

Cited by 81 publications

(49 citation statements)

References 30 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is no longer tenable -neuropathic pain can be relieved by opioids, although it is very likely that relief is obtained only with doses larger than those commonly used for the relief of inflammatory pain and that their efficacy against stimulus-evoked neuropathic pain may be limited (20,21).…”

Section: Treatment Responsesmentioning

confidence: 99%

Can We Distinguish between Inflammatory and Neuropathic Pain?

Bennett

2006

Pain Research and Management

View full text Add to dashboard Cite

GJ Bennett. Can we distinguish between inflammatory and neuropathic pain? Pain Res Manage 2006;11(Suppl A):11A-15A.Inflammatory and neuropathic pain were once considered to be distinct entities. However, research over the past decade or so has brought to light many shared mechanisms, and the distinction between the two is no longer clear. Consideration of mechanisms, symptoms and the effects of analgesic drugs does not reveal any definitive or universally applicable differentiating factors. Given the present level of understanding, it may not be possible to distinguish between inflammatory and neuropathic pain in a large number of patients, and a satisfying definition of neuropathic pain may not be possible.Key Words: Allodynia; Chronic pain; Hyperalgesia; Inflammation; Neuropathy Peut-on distinguer la douleur inflammatoire de la douleur neuropathique ?La douleur inflammatoire et la douleur neuropathique ont déjà été considérées comme des entités distinctes. Cependant, les recherches depuis une dizaine d'années ont mis en lumière de nombreux mécanismes partagés, et la distinction entre les deux types de douleur n'est plus claire. L'évaluation des mécanismes, des symptômes et des effets des analgésiques ne révèle aucun facteur différentiel universellement applicable. Étant donné le niveau de compréhension actuel, il n'est peut-être possible ni de distinguer la douleur inflammatoire de la douleur neuropathique chez un grand nombre de patients, ni de parvenir à une définition satisfaisante de la douleur neuropathique.

show abstract

Section: Treatment Responsesmentioning

confidence: 99%

Can We Distinguish between Inflammatory and Neuropathic Pain?

Bennett

2006

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…8 Opiates are also used and have reported efficacy. 9,10 In the past several years, many other targets/agents have been implicated, but assertions of their efficacy must be considered, dependent on the still evolving data sets.…”

Section: Introductionmentioning

confidence: 99%

Behavioral Models of Pain States Evoked by Physical Injury to the Peripheral Nerve

Sorkin

Yaksh

2009

Neurotherapeutics

View full text Add to dashboard Cite

Summary:Physical injury or compression of the root, dorsal root ganglion, or peripheral sensory axon leads to welldefined changes in biology and function. Behaviorally, humans report ongoing painful dysesthesias and aberrations in function, such that an otherwise innocuous stimulus will yield a pain report. These behavioral reports are believed to reflect the underlying changes in nerve function after injury, wherein increased spontaneous activity arises from the neuroma and dorsal root ganglion and spinal changes increase the response of spinal projection neurons. These pain states are distinct from those associated with tissue injury and pose particular problems in management. To provide for developing an understanding of the underlying mechanisms of these pain states and to promote development of therapeutic agents, preclinical models involving section, compression, and constriction of the peripheral nerve or compression of the dorsal root ganglion have been developed. These models give rise to behaviors, which parallel those observed in the human after nerve injury. The present review considers these models and their application.

show abstract

“…-18 to -10; p<0.001). 15 The overall NNT of opioids for neuropathic pain is 2.5 (CI 2.0-3.2). Secondary outcome parameters such as physical and mental health, sleep and disability were measured in parts of these trials and yielded inconsistent results.…”

mentioning

confidence: 99%