Efficacy of N-Acetylcysteine and Hydrated Sodium Calcium Aluminosilicate to Reduce the Effects of Aflatoxin B1 Intoxication in Broiler Chickens

Attia, Khalil M.; Asser, Mohamed H.; Tawfeek, Fouad; Basuney, Hanaa A.

doi:10.5455/ajvs.34945

Cited by 2 publications

(1 citation statement)

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“…AFB1 contamination level of 100 ppb has no effect on SGOT and SGPT levels because broilers are still able to carry out the detoxification process in the liver. The research results have similarities with Saminathan et al (2018) that AFB1 contamination at a level of 100 µg/kg had no effect on SGOT and SGPT levels, however AFB1 contamination at a level of 1 mg/kg significantly increased SGOT levels by 7.93% and SGPT by 12.33% (Farooqui et al, 2019;Attia et al, 2019). Nazarizadeh and Pourreza (2019) reported that the addition of 1 g/kg mycotoxin binder in feed contaminated with AFB1 at a level of 2 mg/kg reduced the activity of SGPT and SGOT enzymes caused by impaired hepatocyte cell necrosis.…”

Section: Effect Of Toxin Binder Addition On Liver Weight and Sgpt Sgo...supporting

confidence: 58%

Effect of Phyllosilicates As Toxin Binder On Productivity, Intestinal Morphology, and Liver Toxicity in Broiler Fed Afb1 Contaminated Feed

Prahara,

Humaera,

Yusiati

et al. 2023

BuletinPeternak

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Aflatoxin B1 is a toxin produced by the fungus Aspergillus flavus which reduces the development and function of organs in broilers. The aim of this study was to determine the effect of adding binder toxin from different bentonite to feed contaminated with AFB1 on productivity, intestinal morphology, and liver toxicity in broilers. A total of 60-day old chick male broilers were placed in 12 pens. Each treatment consisted of three replicates, each replicate containing five broilers. Treatment in the study consisted of P0 (control, basal diet, without the addition of AFB1), P1 (P0 + 100 µg/kg AFB1 + 4 g/kg calcium bentonite Type A), P2 (P0 + 100 µg/kg AFB1 + 4 g/kg calcium bentonite Type B), and P3 (P0 + 100 µg/kg AFB1 + 4 g/kg calcium bentonite Type B + kerolite + saponite). Treatment diets were given to broilers from day 22 to 35 (finisher phase). The results showed that the toxin binder on AFB1 contaminated feed had no effect on feed consumption, body weight gain and feed conversion (p>0.05). Addition of toxin binder on AFB1 contaminated feed increased the relative weight of the duodenum (p=0.024), although P3 was not significantly different. Treatments had no effect on villus length, crypt depth, and ratio of villus length to crypt depth (p>0.05), but decreased villus width (p=0.013). The addition of toxin binder tended to decrease the villus area (p=0.055). SGOT and SGPT did not show differences between treatments. AFB1 contamination with the addition of toxin binder showed signs of toxicity on liver histopathological observations. Based on the research, it can be concluded that the addition of binder toxin in feed contaminated with AFB1 can reduce the negative effect on the development of intestinal villus and chemical effect to the liver. Toxin binder Type B has the best efficacy for reduce the negative effect

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Section: Effect Of Toxin Binder Addition On Liver Weight and Sgpt Sgo...supporting

confidence: 58%

Effect of Phyllosilicates As Toxin Binder On Productivity, Intestinal Morphology, and Liver Toxicity in Broiler Fed Afb1 Contaminated Feed

Prahara,

Humaera,

Yusiati

et al. 2023

BuletinPeternak

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N-acetyl-L-cysteine improves the performance of chronic cyclic heat-stressed finisher broilers but has no effect on tissue glutathione levels

Pertiwi,

Majdeddin,

Degroote

et al. 2023

British Poultry Science

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Efficacy of N-Acetylcysteine and Hydrated Sodium Calcium Aluminosilicate to Reduce the Effects of Aflatoxin B1 Intoxication in Broiler Chickens

Cited by 2 publications

References 0 publications

Effect of Phyllosilicates As Toxin Binder On Productivity, Intestinal Morphology, and Liver Toxicity in Broiler Fed Afb1 Contaminated Feed

Effect of Phyllosilicates As Toxin Binder On Productivity, Intestinal Morphology, and Liver Toxicity in Broiler Fed Afb1 Contaminated Feed

N-acetyl-L-cysteine improves the performance of chronic cyclic heat-stressed finisher broilers but has no effect on tissue glutathione levels

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