Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients

Van, Thuong Nguyen; Van, Tam Hoang; Minh, Phuong Pham Thi; Trọng, Hào Nguyễn; Van, Tro Chau; Huu, Nghi Dinh; Thi, Thao Pham; Thu, Hien Do Thi; Cam, Van Tran; Huyen, My Le; Hau, Khang Tran; Gandolfi, Marco; Satolli, Francesca; Feliciani, Claudio; Tirant, Michael; Vojvodić, Aleksandra; Lotti, Torello

doi:10.3889/oamjms.2019.057

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…21,22 UV-based treatments have an important place in the treatment of psoriasis, often successful results are obtained with NB-UVB and PUVA treatments. 23 However, PUVA is considered as a potential human carcinogen due to its immunosuppressive and mutagenic effects. It is known that PUVA therapy causes skin cancers in a dosedependent manner.…”

Section: Discussionmentioning

confidence: 99%

Does the risk of basal cell carcinoma increase in patients with psoriasis under treatment?

Sevdem,

Ozlem,

Nazan

et al. 2024

Photoderm Photoimm Photomed

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BackgroundPsoriasis is a common, chronic, inflammatory disease. Although it mainly affects the skin, it has been associated with a large number of comorbidities. In addition to comorbidities such as depression and psoriatic arthritis, it is known that there is an increased prevalence of cancer in psoriasis patients. Skin cancers, particularly squamous cell carcinoma, have been associated with psoriasis. However, basal cell carcinoma data are limited.Methods346 psoriasis patients and 306 individuals were selected as the control group. There were no differences between the patient and control groups in terms of age and gender. The mean age of the psoriasis patients was 49.9 ± 15.8 years and the control group was 49.4 ± 13.4 years. Sociodemographic data of the patients were recorded. Pharmacological agents used in the treatment of psoriasis were included in the analysis. Disease severity was assessed by the psoriasis area severity index (PASI). In the physical examination of the patients, biopsies were taken from lesions suspicious for BCC. BCC diagnosis was made by histopathologically.ResultsThe frequency of BCC was higher in psoriasis patients than in the control group (6.6% vs. 2.9%, p < .001). Advanced age (p < .001), smoking (p = .003), and arthritis (p < .001) were associated with BCC in psoriasis patients. However, there was no relationship between PASI and BCC (p = .142). Among the psoriasis treatments, only UV therapy was associated with BCC (p = .038). The frequency of PUVA (p < .001) and number of PUVA session (p = .010) was higher in psoriasis patients with BCC rather than NB‐UVB.ConclusionThe frequency of BCC is increased in psoriasis patients. Psoriasis is associated with an increased risk of BCC, especially when treated with PUVA therapy for a long time.

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Section: Discussionmentioning

confidence: 99%

Does the risk of basal cell carcinoma increase in patients with psoriasis under treatment?

Sevdem,

Ozlem,

Nazan

et al. 2024

Photoderm Photoimm Photomed

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“…In general, NB-UVB phototherapy is recommended for moderate-severe psoriasis vulgaris. 8 NB-UVB was the first-line phototherapy for moderate-severe plaque-type psoriasis vulgaris with an extensive skin involvement accompanied by thick plaques. In moderate-severe psoriasis vulgaris, there was an increase in the intensity of redness, desquamation, and extensive plaque thickness.…”

Section: Discussionmentioning

confidence: 99%

Combination effect of methotrexate with Narrowband Ultraviolet B (NB-UVB) phototherapy in psoriasis vulgaris patients in dermatology and venereology outpatient clinic Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

et al. 2022

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Background: Psoriasis is a chronic, recurrent, inflammatory skin disease that alters the quality of life. Systemic therapy and biologic agents are prescribed for severe and widespread psoriasis, but these drugs may have systemic side effects and immune suppression. Narrowband Ultraviolet B (NB-UVB) phototherapy remains one of the most effective and safe treatments for psoriasis.Methods: This study was an observational retrospective cohort with one group pretest and post-test design. A retrospective analysis was done on 16 medical records of patients who met the inclusion criteria. The efficacy of the therapy was identified and analyzed using the SPSS version 17 for Windows.Results: This study found that 16 psoriasis patients received NB-UVB phototherapy, 11 (68.75%) in men and 5 (31.25%) in women. The mean age was 47.31 years. There was a statistically significant difference in the reduction in PASI score before and after receiving combination methotrexate with 24 sessions of NB-UVB phototherapy (p=0.000); the delta PASI score was 45,02%. A statistical analysis based on the number of phototherapy sessions per week showed enhanced results when patients attended 3 phototherapy sessions per week (p = 0.001).Conclusion: There was a statistically significant reduction in PASI score in psoriasis vulgaris patients before and after receiving combination methotrexate with 24 sessions of NB-UVB phototherapy.

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(Photo)chemotherapeutic

Albini¹

2020

Light, Molecules, Reaction and Health

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Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients

Cited by 7 publications

References 13 publications

Does the risk of basal cell carcinoma increase in patients with psoriasis under treatment?

Does the risk of basal cell carcinoma increase in patients with psoriasis under treatment?

Combination effect of methotrexate with Narrowband Ultraviolet B (NB-UVB) phototherapy in psoriasis vulgaris patients in dermatology and venereology outpatient clinic Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

(Photo)chemotherapeutic

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