Efficacy of Naturopathic Extracts in the Management of Ear Pain Associated With Acute Otitis Media

Sarrell, E. Michael; Mandelberg, Avigdor; Cohen, Herman Avner

doi:10.1001/archpedi.155.7.796

Cited by 74 publications

(43 citation statements)

References 26 publications

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“…In the first trial (Sarrell 2001), the anaesthetic group showed a mean pain score of 8.53 at baseline. It had declined to 5.6 15 minutes after instillation, and to 4.3 30 minutes after instillation on day 1.…”

Section: R E S U L T Smentioning

confidence: 99%

Topical analgesia for acute otitis media

Foxlee

Johansson²,

Wejfalk³

et al. 2006

Cochrane Database of Systematic Reviews

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BackgroundAcute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed. ObjectivesTo assess the effectiveness of topical analgesia for AOM. Search strategyWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2006), MEDLINE (1966 to May Week 3 2006, EMBASE (1990 to December 2005 and LILACS (1982 to September 2005) without language restriction, and the reference lists of articles. We also contacted manufacturers and authors. Selection criteriaDouble-blind randomised or quasi-randomised controlled trials comparing an otic preparation with an analgesic effect (excluding antibiotics) versus placebo or an otic preparation with an analgesic effect (excluding antibiotics) versus any other otic preparation with an analgesic effect, in adults or children presenting at primary care settings with AOM without perforation. Data collection and analysisPotential studies were screened independently and trial quality was assessed by three authors, and differences were resolved by discussion. Data was then independently extracted from the trials selected by two authors. We contacted the authors of three trials to acquire additional information not available in published articles. Main resultsOur searches yielded 356 records; four trials met our criteria. One trial with 54 participants compared treatment with anaesthetic ear drops versus an olive oil placebo immediately at diagnosis. All patients were also given paracetamol. There was a statistically significant pain reduction of 25% in those receiving anaesthetic drops 30 minutes after instillation. Three trials (with one common co-author) compared anaesthetic ear drops with naturopathic herbal ear drops in 274 patients. One of these trials also used antibiotics in both groups. There were statistically significant differences at instillation of drops, or 15 or 30 minutes after the instillation (or both) on one to three days after diagnosis, always favouring the naturopathic group in each trial.

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Section: R E S U L T Smentioning

confidence: 99%

Topical analgesia for acute otitis media

Foxlee

Johansson²,

Wejfalk³

et al. 2006

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…The studies were assessed independently by three authors (JD, ACJ and JW) and differences of opinion were resolved by discussion. Only four trials fulfilled the criteria (Hoberman 1997;Sarrell 2001;Sarrell 2003a;Sarrell 2003b), two trials were reported in one paper (Sarrell 2003a;Sarrell 2003b). An unpublished trial (Matz 2001a) was identified through personal communications but was excluded.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…One of these (Sarrell 2001) included 110 children aged between 6 to 18 years with ear pain and for whom a clinical diagnosis of otitis media was made, enhanced by tympanometry. Children were excluded if they had used any ear drops or analgesics within the preceding four hours; had a known allergy to either of the preparations being tested; had otorrhoea, eardrum perforation, ventilation tube(s), known immune deficiency, a past history of complicated AOM, a history of treated or untreated ear disease in the two weeks prior to enrolment in the study or were unable to reliably use a visual analog pain scale.…”

Section: E S C R I P T I O N O F S T U D I E Smentioning

confidence: 99%

“…Participants in this trial (Sarrell 2001) were randomised to receive either anaesthetic ear drops (amethocaine, phenazone and glycerine) or naturopathic herbal extract ear drops (Allium sativum, Verbascum thapsus, Calendula flores and Hypericum perforatum in olive oil). Five drops of either solution were instilled into the ear three times daily for three days.…”

Section: E S C R I P T I O N O F S T U D I E Smentioning

confidence: 99%

“…The diagnosis was primarily clinical, enhanced by tympanometry. In addition to the exclusion criteria in the first trial (Sarrell 2001), children with otologic or craniofacial malformations were also excluded. The children were assigned by computer-numbered randomisation to receive either anaesthetic ear drops (amethocaine, phenazone and glycerine) or naturopathic herbal extract ear drops (Allium sativum, Verbascum thapsus, Calendula flores, Hypericum perfoliatum, Lavandulla officinalis, and vitamin E in olive oil).…”

Section: E S C R I P T I O N O F S T U D I E Smentioning

confidence: 99%

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