Efficacy of NB-UVB, microneedling with triamcinolone acetonide, and a combination of both modalities in the treatment of vitiligo: A comparative study

Khashaba, Shrook A; Elkot, Reham; Ibrahim, Al-Shimaa M

doi:10.1016/j.jaad.2017.12.054

Cited by 28 publications

(19 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another clinical study compared the efficacy of microneedling alone or with NB‐UVB vs NB‐UVB alone. It proved that needling and NB‐UVB yielded better results when combined together 17 . Repigmentation was seen in all patients treated with combined therapy, and in 80% of patients treated with NB‐UVB or microneedling monotherapy 17 .…”

Section: Resultsmentioning

confidence: 95%

“…It proved that needling and NB‐UVB yielded better results when combined together 17 . Repigmentation was seen in all patients treated with combined therapy, and in 80% of patients treated with NB‐UVB or microneedling monotherapy 17 . The grade of repigmentation in each group is: NB‐UVB monotherapy: G1 (n = 6), G2 (n = 6), G3 (n = 4); microneedling and triamcinolone acetonide solution: G1 (n = 3), G2 (n = 4), G3 (n = 6), G4 (n = 3); combination of both modalities: G1 (n = 1), G2 (n = 5), G3 (n = 8), G4 (n = 6).…”

Section: Resultsmentioning

confidence: 97%

“…Most patients were photographed pre and post treatment using standard camera or UV light pictures. The most common scale used to assess repigmentation was the 5‐grade repigmentation scale (or Physician's Global Assessment [PGA]) (G0‐G4; [11]): G4 (excellent: >75% repigmentation), G3 (very good: 50%‐75% repigmentation), G2 (good: 25%‐50%), G1 (satisfactory: <25% repigmentation), and G0 (poor: no repigmentation) 11,13‐18 . Visual analog scale was used in three studies 10,18‐20 .…”

Section: Resultsmentioning

confidence: 99%

“…None of the patients had severe adverse events related to the microneedling treatment. The post procedure adverse events were: pain, 11,14‐17,22 erythema, 15,16,22 hyperpigmentation, 13 itching, 14,16 ulceration, 13 inflammation, 13 and exfoliation 15 …”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Microneedling was initially introduced for skin rejuvenation; however, this minimally invasive procedure is now being used for the treatment of multiple dermatological conditions. Recent reports have shown its efficacy in the treatment of vitiligo. This review analyzes the current literature on microneedling techniques, efficacy, and safety for vitiligo treatment. An extensive PubMed was done to identify the literature on microneedling treatment for vitiligo. Case reports, case series, and clinical trials were included in this review. All 14 articles evaluated showed improvement of vitiligo lesions after microneedling treatment. The combination of microneedling and topical tacrolimus, 5-fluorouracil, topical calcipotriol and betamethasone, narrowband ultraviolet B with or without photodynamic therapy, and triamcinolone acetonide solution yielded more efficacy than microneedling monotherapy. Microneedling is a safe and efficient technique in the treatment of vitiligo. Thus, it can be an alternative treatment for vitiligo especially when the latter is resistant to conventional therapies.

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Microneedling is a minimally invasive procedure that is initially introduced in dermatology for skin rejuvenation. It was recently recommended for treating resistant localized stable vitiligo either as an exclusive therapy 5 or in combination with NB‐UVB phototherapy, 6 or topical therapeutic agents such as triamcinolone acetonide, 7 latanoprost, 8,9 tacrolimus, 9,10 5‐fluorouracil, 11 or trichloroacetic acid 12 . It induces processes similar to wound healing with production of cytokines and growth factors beneficial for repigmentation.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of combined microneedling and narrowband ultraviolet B phototherapy versus their combination with topical latanoprost in the treatment of vitiligo

Neinaa

Lotfy²,

Ghaly

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Regardless of the continuous discovery of innovative modalities for the treatment of vitiligo, none of them ensure excellent therapeutic outcome. Microneedling had been suggested either singly or concomitantly with other therapeutic modalities for vitiligo with encouraging results. Latanoprost, a prostaglandin F2-alpha (PGF2α), and their analogues are recently recommended for vitiligo treatment. This study was designed to assess the therapeutic efficacy of microneedling in combination with NB-UVB phototherapy versus their combination with latanoprost in vitiligo. It was conducted on 50 patients presented with stable bilateral localized nonsegmental vitiligo. In every patient; two bilateral, nearly symmetrical lesions were selected and treated by microneedling (12 sessions at 2-week interval) followed by topical application of latanoprost 0.005% solution on one side, and topical saline (as placebo) on the other side. In addition, all patients received concomitant NB-UVB phototherapy (three sessions/week) for 6 months. Significant clinical improvement of vitiligo lesions with significant increase in the degree of repigmentation were reported in response to both treatment regimens. Latanoprost in combination with microneedling and NB-UVB provides more significant therapeutic outcomes than combined microneedling and NB-UVB. In conclusion, topical latanoprost 0.005% enhances the therapeutic efficacy of combined microneedling and NB-UVB phototherapy in localized stable nonsegmental vitiligo.

show abstract