“…Although many endodontic therapies have been introduced, including negative-pressure irrigation, ultrasonic irrigation, sonic irrigation, laser, and photoinduced photo-acoustic streaming (PIPS), none have provided sufficient evidence of adequate debridement and disinfection within the root canal system to prevent the onset and exacerbation of apical periodontitis. 19,[26][27][28] Unfortunately, the safety, efficacy, and reliability of such devices are not well-established. [26][27][28][29][30] For example, because positive pressure is created at the apex with PIPS and standard needle irrigation systems, irritants …”