Efficacy of Nefopam for the Prevention and Treatment of Amphotericin B—Induced Shivering

Rosa, Giovanni; Dell’Utri, Donatella; Conti, Giorgio; Pelaia, P; Cogliati, Alessandro; Orsi, Paolo; Gasparetto, A

doi:10.1001/archinte.1997.00440350097010

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…17 Nefopam, a nonopioid analgesic, has been shown to be more effective than meperidine in amphotericin B-induced rigors but can also be associated with significant adverse effects (ie, sweating and vasoconstriction). 26, 27 In a randomized double-blind study that compared the efficacy of clonidine 3 µg/kg and nefopam 15 mg/kg, both agents were effective. However, nefopam provided the highest response rate.…”

Section: Discussionmentioning

confidence: 99%

Dantrolene Sodium for the Treatment of Aldesleukin-lnduced Rigors in a Melanoma Patient

Azari¹,

Sheehan²,

Sachdev³

et al. 2012

Ann Pharmacother

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Section: Discussionmentioning

confidence: 99%

Dantrolene Sodium for the Treatment of Aldesleukin-lnduced Rigors in a Melanoma Patient

Azari¹,

Sheehan²,

Sachdev³

et al. 2012

Ann Pharmacother

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“…Intra‐operative mild hypothermia may protect the brain during neurosurgery; on the other hand, early postoperative awakening allows rapid clinical evaluation. Several drugs have been recommended for the treatment of shivering, and nefopam has been shown to treat and prevent post anaesthetic [15, 16] and amphotericin‐B‐induced shivering [24]. Furthermore, in the postoperative setting, nefopam does not influence the recovery time, which is not surprising because nefopam has no sedative effects [15, 16].…”

Section: Discussionmentioning

confidence: 99%

Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients

et al. 2001

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We evaluated the haemodynamic and metabolic effects of prevention of shivering after prophylactic nefopam administration in neurosurgical patients undergoing craniotomy and mild systemic hypothermia (33-35 degrees C). Forty patients were enrolled in a randomised, double-blind study. Before extubation, patients received intravenously either nefopam 0.12 mg.kg-1 or an equal volume of saline 0.9%. Left ventricular systolic work index, oxygen consumption index and systemic lactate concentration were recorded before, immediately after and every 20 min for 2 h after extubation. Shivering appeared in two patients treated with nefopam and in all control patients (p < 0.001). Both left ventricular systolic work index and oxygen consumption index were similar in the two groups before extubation, increased after extubation, and further increased in control patients showing a statistical difference compared to patients treated with nefopam. Our results suggest that nefopam is effective in preventing postoperative shivering in patients undergoing neurosurgery and mild hypothermia and attenuates the haemodynamic effects of shivering during rewarming.

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Nefopam rec. INN, BAN, Nefopan hchl. USAN, Benzoxazocine, R 738 (Code)

Waldvogel¹

2001

Analgetika Antinozizeptiva Adjuvanzien

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Efficacy of Nefopam for the Prevention and Treatment of Amphotericin B—Induced Shivering

Abstract: Nefopam seems to be more effective than meperidine in preventing and quickly suppressing amphotericin B-induced shivering.

Cited by 10 publications

References 13 publications

Dantrolene Sodium for the Treatment of Aldesleukin-lnduced Rigors in a Melanoma Patient

Dantrolene Sodium for the Treatment of Aldesleukin-lnduced Rigors in a Melanoma Patient

Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients

Nefopam rec. INN, BAN, Nefopan hchl. USAN, Benzoxazocine, R 738 (Code)

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