Efficacy of nifedipine in the treatment of angina pectoris and chronic airways obstruction

Abstract

SummaryTwenty patients suffering from angina pectoris with co-existing fixed or labile airways obstruction, were administered fortnightly treatment periods of nifedipine or matching placebo over an 8-week period. Maintenance treatment for their airways obstruction continued throughout this period. Nifedipine was found to be an effective drug in controlling their angina, and did not have an adverse effect on the airways obstruction. Both systolic and diastolic BP was reduced over a 90-min period after administration of a single dose of nifedipine.

Some Extracardiac Effects of Diltiazem and Other Calcium Entry Blockers

“…In man. neither verapamil nor nifedipine had any effect on pulmonary function under resting conditions (Ringqvist 1974;Jaiprakash et al 1980;Barnes et al 198 1;Svedmyr et al 1984). However, the drugs were shown to have some protective effect against bronchoconstriction induced by, e.g., exercise (Cerrina et al 1981;Barnes et ul.…”