Efficacy of nonsurgical periodontal therapy affecting salivary biomarkers in non-diabetic and type 2 diabetic periodontitis patients. An observational study

Hungund, Shital; Desai, Vishal; Shah, Mihir; Shekar, Manikantan; Deka, Anupam; Sarmah, Saswati

doi:10.1016/j.jobcr.2023.05.012

Cited by 2 publications

(2 citation statements)

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“…Moreover, studies have demonstrated the effectiveness of nonsurgical periodontal therapy in influencing salivary biomarkers, including CRP, in individuals with T2D and non-diabetic generalized chronic periodontitis. Non-surgical periodontal therapy has significantly reduced CRP levels in diabetics and non-diabetics, suggesting its potential role in lowering crucial salivary biomarkers and monitoring disease progression [ 41 ]. As a noninvasive diagnostic tool, saliva can be critical in monitoring glucose levels in p with T2D and chronic periodontitis, offering a valuable approach to disease management and treatment evaluation [ 41 ].…”

Section: Reviewmentioning

confidence: 99%

“…Non-surgical periodontal therapy has significantly reduced CRP levels in diabetics and non-diabetics, suggesting its potential role in lowering crucial salivary biomarkers and monitoring disease progression [ 41 ]. As a noninvasive diagnostic tool, saliva can be critical in monitoring glucose levels in p with T2D and chronic periodontitis, offering a valuable approach to disease management and treatment evaluation [ 41 ].…”

Section: Reviewmentioning

confidence: 99%

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Salivary High-Sensitivity C-Reactive Protein and Its Clinical Relevance in Modern Medicine: A Comprehensive Review

Bedi,

Acharya,

Kumar

et al. 2024

Cureus

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High-sensitivity C-reactive protein (hsCRP) has emerged as a critical biomarker in inflammation, offering insights into various chronic diseases. However, traditional blood-based assays for hsCRP measurement pose limitations regarding invasiveness and cost. In recent years, saliva has garnered attention as an alternative diagnostic medium, presenting a noninvasive and easily accessible option for biomarker analysis. Salivary hsCRP has thus emerged as a promising avenue for research and clinical application, offering potential advantages over blood-based assays. This comprehensive review aims to elucidate the biological basis of salivary hsCRP, its clinical applications, and methodologies for measurement. By exploring its diagnostic potential, prognostic value, and implications for treatment monitoring, this review highlights the potential impact of salivary hsCRP in modern medicine. Moreover, it emphasizes the need for continued exploration, validation, and integration of salivary hsCRP into routine clinical practice to realize its full potential for enhancing patient care and advancing personalized medicine approaches.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Salivary High-Sensitivity C-Reactive Protein and Its Clinical Relevance in Modern Medicine: A Comprehensive Review

Bedi,

Acharya,

Kumar

et al. 2024

Cureus

View full text Add to dashboard Cite

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Exploring Salivary Alpha-Amylase as a Biomarker in Periodontitis: A Comparative Analysis of Disease Stages and Clinical Correlations

Hashim,

Fathima,

Hisham

et al. 2024

CIMB

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Periodontal disease, characterized by bacterial plaque accumulation and subsequent immune response, can lead to gingivitis and periodontitis if untreated. Salivary alpha-amylase (sAA) has emerged as a potential biomarker with implications in periodontal disease progression. Objectives: This study aimed to assess and compare salivary alpha-amylase levels in individuals with periodontitis and healthy controls and to investigate its relationship with clinical parameters of periodontal disease. Forty-five participants were categorized into periodontally healthy (n = 13), Stage I and II Periodontitis (n = 17), and Stage III and IV periodontitis (n = 15) groups. Saliva samples were collected and analyzed using ELISA kits. Statistical analyses included tests for normality, group comparisons, post hoc analysis, and correlation analysis. Significant differences in salivary alpha-amylase levels were observed among severity groups (p < 0.05), with higher levels in periodontitis patients than healthy controls. Spearman correlation revealed moderate positive associations between alpha-amylase levels and probing depth (PD) and clinical attachment loss (CAL). Elevated salivary alpha-amylase levels were found to be associated with more severe periodontal disease, suggesting its potential as a biomarker for periodontitis severity. These findings support the utility of salivary biomarkers in periodontal disease diagnosis and monitoring, although further validation and standardization are warranted for clinical application.

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Efficacy of nonsurgical periodontal therapy affecting salivary biomarkers in non-diabetic and type 2 diabetic periodontitis patients. An observational study

Cited by 2 publications

References 48 publications

Salivary High-Sensitivity C-Reactive Protein and Its Clinical Relevance in Modern Medicine: A Comprehensive Review

Salivary High-Sensitivity C-Reactive Protein and Its Clinical Relevance in Modern Medicine: A Comprehensive Review

Exploring Salivary Alpha-Amylase as a Biomarker in Periodontitis: A Comparative Analysis of Disease Stages and Clinical Correlations

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