Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin‐induced acute mastitis

Abstract

One hind quarter of 27 healthy lactating cows was infused with 100 microg Escherichia coli endotoxin. Two hours later, nine of the cows were given physiological saline by intramuscular injection, nine were given 4 mg/kg ketoprofen orally, and nine were given 3 mg/kg ketoprofen by intramuscular injection. Ketoprofen administered either orally or parenterally significantly reduced the effect of the endotoxin on rectal temperature, ruminal contractions and respiratory rate. The size of the udder, the signs of pain and the concentrations of thromboxane B2, especially in plasma, were also reduced, and the appearance of their milk was almost normal. The response of cows to the oral treatment was as rapid as it was to intramuscular treatment.

GROWTH AND DEVELOPMENT SYMPOSIUM: Inflammation: Role in the etiology and pathophysiology of clinical mastitis in dairy cows1

“…Pharmacological strategies to reduce the production of inftammatory mediators produced via the cyclooxygenase and lipoxygenase pathways have been studied extensively (Burvenich and Peeters, 1982;Anderson et al, 1986;Burvenich et al, 1989;Lohuis et al, 1989Lohuis et al, , 1991Rose et al, 1991;DeGraves and Anderson, 1993;Shpigel et al, 1994;Vangroenweghe et al, 2005;Banting et al, 2008). In those studies, pharmacological doses of nonsteroidal antiinftammatory dmgs were given either before the inftammatory challenge or at the onset of clinical signs of disease.…”

Assessment and Management of Pain in Dairy Cows with Clinical Mastitis

“…The 2 groups of experimental animals were given ketoprofen either orally or intramuscularly 2 hours after LPS mastitis was induced. 67 Untreated control animals showed an increase in rectal temperature to an average of 40.5°C with differences between the groups seen at 6, 8, and 10 hours postchallenge. By 2 hours postchallenge, respiratory rates were increased.…”

“…Other studies that have treated cows with meloxicam have recorded the alleviation of pain and discomfort associated with mastitis, by reducing heart and respiratory rates and pain responses in lactating dairy cows. 78 The use of NSAIDs for the treatment of mastitis has been most commonly prescribed for cases of severe endotoxic mastitis and has not been widely adopted as a standard treatment for cases of mild and moderate clinical mastitis. It is well recognized that for such cases, treatment decisions do not often directly involve veterinarians.…”

Therapeutic efficacy of Chymotrypsin in acute bovine mastitis

“…Entre los fármacos comúnmente utilizados en los Estados Unidos con estas características, está el flunixin meglumina, el cual además, tiene potencial analgésico, antiinflamatorio y antipirético (9); siendo un principio activo que además de acelerar la recuperación de la glándula es capaz de favorecer la eliminación bacteriana. Otros como el ketoprofeno, también poseen una reconocida capacidad antiendotoxémica y pueden ser de utilidad en el momento del tratamiento (10). De igual manera su capacidad (sodium, potassium, procaine and benzathine), synthetic ones such as ampicillin, amoxicillin and anti-staphylococcus drugs (cloxacillin, oxacillin, nafcillin, meticillin); cephalosporins (Cefapirin, cefalonium, cephalothin, cefoperazone, ceftiofur, cefquinome); aminoglycosides such as dihydrostreptomycin, gentamicin and neomycin; aminocoumarins (novobiocin); fluoroquinolones (norfloxacin); tetracyclines (oxytetracycline); macrolides (erythromycin); lincosamides such as lincomycin and pirlimycin; chloramphenicol, among others.…”

“…Among the commonly used drugs in the United States that have these characteristics, flunixin meglumine also has analgesic, antiinflammatory and antipyretic properties (9) that accelerates gland recovery and bacterial elimination. Others, such as ketoprofen, also have a recognized antiendotoxemic action (10), and its analgesic effect is important to improve udder health and milk production (11).…”