Efficacy of oral nystatin treatment for patients with oral mucosal dysesthesia but without objective oral mucosal manifestations and necessity of Candida culture test before oral nystatin treatment

Peng, Ding-Shan; Lo, Chih Hui; Tseng, Yung Zu; Kuo, Shun-Li; Chiang, Chun‐Pin; Chiang, Meng-Ling

doi:10.1016/j.jds.2022.08.005

Journal of Dental Sciences

2022

DOI: 10.1016/j.jds.2022.08.005

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Efficacy of oral nystatin treatment for patients with oral mucosal dysesthesia but without objective oral mucosal manifestations and necessity of Candida culture test before oral nystatin treatment

Ding-Shan Peng

Chih Hui Lo

Yung Zu Tseng

et al.

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Cited by 2 publications

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Nanoparticulate Herbal Formulation for the Management of Fungal Infection

Gupta,

Malviya,

Sundram

et al. 2024

NANOASIA

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Fungal infections have been more common during the past few years as a result of an increase in the population of immunocompromised people, including those with cancer, HIV/AIDS, and organ transplant recipients. It has been reported that fungal infection is brought on by different pathogens. The main focus of this review is the use of nanosized plant components to stop fungal infections for the pharmaceutical industry and research projects. According to research about 40 million people have fungal infections. Echinocandins, griseofulvin, azoles, allylamines, and flucytosine are only a few antifungal medications used in clinical settings to treat fungal infections. Skin infections caused by fungi are among the most prevalent dermatological issues of today. Fungal infections at the skin's surface or under the skin's surface may harm the skin, keratinous tissues, and mucous membranes. Therefore, there is a high need for producing an antifungal agent that may act selectively on new targets while having minor side effects and can belong to a variety of structural classes. Natural goods offer limitless prospects for innovative medicine development due to their typically unrivaled chemical variety, whether in the form of pure phyto-compounds or standardized plant extracts. Plants have been an excellent source of medicine since the beginning of time. When compared to synthetically produced medications, phytochemicals from various plant species have been versicolor as a more potent source of therapy. Novel cell targets and antifungal chemicals, as well as new methods for the delivery of drugs based on nanotechnology, are all currently being studied.

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Nanoparticulate Herbal Formulation for the Management of Fungal Infection

Gupta,

Malviya,

Sundram

et al. 2024

NANOASIA

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Nysfungin Production Improvement by UV Mutagenesis in Streptomyces noursei D-3-14

Song

Cai

et al. 2023

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Streptomyces noursei D-3-14 was taken as a starting strain and treated with UV (15 W, 30 cm) mutagenesis for 40 s for three consecutive rounds. High yielding strains were screened using chemical and biological potency determination, and the components of the fermentation products were detected using HPLC. Finally, the mutant strain Streptomyces noursei 72-22-1 with a chemical potency of 8912 (U/mL) and a biological potency of 5557 (U/mL) was obtained after the genetic stability evaluation. After optimization of the fermentation conditions, the chemical potency and biological potency of Streptomyces noursei 72-22-1 reached 14,082 U/mL and 10579 U/mL, respectively, which is 1.58 and 1.91 times those before optimization. HPLC analysis indicated that the mutant strain 72-22-1 displayed a higher content of polyfungin B. When equimolar nystatin A1, A3, and polyfungin B were tested for their fungicidal activities towards Saccharomyces cerevisiae ATCC 2061, polyfungin B exhibited a better efficacy than nystatin A1 and A3.

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Efficacy of oral nystatin treatment for patients with oral mucosal dysesthesia but without objective oral mucosal manifestations and necessity of Candida culture test before oral nystatin treatment

Cited by 2 publications

References 61 publications

Nanoparticulate Herbal Formulation for the Management of Fungal Infection

Nanoparticulate Herbal Formulation for the Management of Fungal Infection

Nysfungin Production Improvement by UV Mutagenesis in Streptomyces noursei D-3-14

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