Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs

Kraus, Bonnie L. Hay

doi:10.2460/javma.244.10.1164

Cited by 18 publications

(18 citation statements)

References 34 publications

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“…). Administration of hydromorphone IM alone induced vomiting in 25% of dogs at 0.1 mg kg −1 (Hay Kraus ) and in 87% of dogs at 0.2 mg kg −1 (Claude et al. ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of acupuncture point Pericardium 6 on hydromorphone-induced nausea and vomiting in healthy dogs

Scallan

Simon

2016

Veterinary Anaesthesia and Analgesia

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“…). Administration of hydromorphone IM alone induced vomiting in 25% of dogs at 0.1 mg kg −1 (Hay Kraus ) and in 87% of dogs at 0.2 mg kg −1 (Claude et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…). Thus, the presence of vomiting after hydromorphone administration seems to vary with study conditions, duration and presence of fasting, between client‐owned and research‐bred animal populations, and according to the dose and route of the hydromorphone, and concurrent administration of other medications (Hay Kraus ).…”

Section: Discussionmentioning

confidence: 99%

The effects of acupuncture point Pericardium 6 on hydromorphone-induced nausea and vomiting in healthy dogs

Scallan

Simon

2016

Veterinary Anaesthesia and Analgesia

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“…() reported a single daily dose of maropitant to be more effective than metoclopramide administered two or three times daily in the treatment of emesis caused by various aetiologies in dogs; however, the number of PVE‐induced cases was very limited (two out of 183 cases) in that study. In other studies, maropitant was found to be effective in morphine‐ (Koh, Isaza, Xie, Cooke, & Robertson, ) or hydromorphone (Hay Kraus, )‐induced vomiting.…”

Section: Discussionmentioning

confidence: 88%

Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis‐induced emesis in dogs

Yalçın

Keser

2017

Vet Pharm & Therapeutics

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The aim of the study was to evaluate the efficiencies of selected anti-emetic drugs (metoclopramide, ondansetron and maropitant) in preventing vomiting in the treatment of canine parvoviral enteritis. We designed a randomized, prospective clinical study. PVE quick ELISA test-positive dogs between 4 and 12 months of age were included in the study. Each of metoclopramide, ondansetron, maropitant and control group had 8 dogs. Metoclopramide and ondansetron were administered as 0.5 mg/kg doses three times a day via intravenous route, and maropitant was administered as 1 mg/kg doses once a day subcutaneously. The number and severity of daily vomitings were recorded. All dogs were treated and monitored for five days; treatments were continued until all animals healed. Metoclopramide, ondansetron and maropitant decreased the severity of vomiting from the first day and the vomiting numbers from the third day in PVE treatment. Obtained results showed that maropitant can be used successfully such as metoclopramide and ondansetron, which are frequently used for PVE treatment. At the same time, it was discovered that metoclopramide, ondansetron and maropitant were equally effective in reducing the frequency and severity of vomiting.

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“…A subsequent study evaluated the effectiveness of the oral tablets in preventing vomiting and signs of nausea in dogs premedicated with hydromorphone. 21 Forty dogs were dosed with either placebo or maropitant citrate tablets (2.0–4.0 mg/kg) per oral (PO) 2 hours prior to hydromorphone (0.1 mg/kg) IM. Dogs were observed for vomiting and signs of nausea using the same definitions as the previous study.…”

Section: Treatment/prevention Of Perioperative Vomiting and Signs Of mentioning

confidence: 99%

“…In this study, although oral maropitant prevented vomiting, it did not prevent signs of nausea and, in fact, caused more severe signs of nausea associated with hydromorphone administration. 21 …”

Section: Treatment/prevention Of Perioperative Vomiting and Signs Of mentioning

confidence: 99%

Spotlight on the perioperative use of maropitant citrate

Kraus¹

2017

VMRR

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Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (SP) is the major ligand and is involved in multiple processes including pain transmission, vasodilation, modulation of the inflammatory response, as well as the sensory neuronal transmission involved in stress, anxiety, and emesis. The involvement of NK-1 and SP in the vomiting reflex has led to the development of NK-1 antagonists to prevent and treat vomiting in human and veterinary medicine. Maropitant is a potent, selective neurokinin (NK-1) receptor antagonist that blocks the pharmacologic action of SP in the central nervous system. Maropitant is available in both an injectable and tablet formulation and approved for use in dogs and cats for the treatment and prevention of vomiting from a variety of clinical causes and motion sickness. When administered prior to anesthetic premedication, maropitant prevents or significantly decreases the incidence of opioid-induced vomiting and signs of nausea in dogs and cats. Maropitant has also been shown to improve postoperative return to feeding and food intake in dogs. The minimum alveolar concentration of sevoflurage is decreased in both dogs and cats by maropitant, indicating a potential role as an adjunct analgesic, especially for visceral pain. This article will review the background information and literature, including clinical recommendations with respect to the perioperative use of maropitant in canine and feline veterinary patients.

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Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs

Abstract: Among the 40 study dogs, the incidence of vomiting associated with hydromorphone administration was 25%. Oral administration of maropitant prevented vomiting but not signs of nausea associated with hydromorphone administration in dogs.

Cited by 18 publications

References 34 publications

The effects of acupuncture point Pericardium 6 on hydromorphone-induced nausea and vomiting in healthy dogs

The effects of acupuncture point Pericardium 6 on hydromorphone-induced nausea and vomiting in healthy dogs

Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis‐induced emesis in dogs

Spotlight on the perioperative use of maropitant citrate

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