Efficacy of orgotein in prevention of late side effects of pelvic irradiation: A randomized study

Escó, R.; Valencia, Javier; Coronel, Pilar; Carceller, J.A.; Gimeno, Mercedes; Bascón, Natividad

doi:10.1016/j.ijrobp.2004.04.038

Cited by 28 publications

(15 citation statements)

References 8 publications

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“…The final concentration of the enzyme was 10 times high when compared with the yield from baker's yeast and stable for 2 years under 8°C without retarding its activity. The same drug have shown many pharmaceutical applications in human clinical trials [42].…”

Section: Industrial Applications Of Sodmentioning

confidence: 99%

Industrial Production of Superoxide Dismutase (SOD): A Mini Review

Gopal¹,

Elumalai²

2017

J Prob Health

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The use of chemical advances to mechanical research, improvement, and assembling has turned into a critical field. Since the creation of rough rennet in 1874, a few catalysts have been marketed, and utilized for restorative, supplementary, and different applications. Late headways in biotechnology now enable organizations to create more secure and more affordable chemicals with upgraded intensity and specificity. Cancer prevention agent catalysts are developing as another expansion to the pool of modern chemicals and are outperforming every single other compound as far as the volume of research and creation. In the 1990s, a cell reinforcement chemical-superoxide dismutase (SOD) was brought into the market. In spite of the fact that the catalyst at first demonstrated extraordinary guarantee in restorative applications, it didn't perform up to desires. Therefore, its utilization was restricted to nontranquilize applications in people and medication applications in creatures. This survey compresses the ascent and fall of SOD at the mechanical level, the purposes behind this, and potential future push territories that should be tended to. The audit likewise concentrates on other modernly significant parts of SOD, for example, mechanical significance, catalyst designing, generation procedures, and process streamlining and scale-up.

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Section: Industrial Applications Of Sodmentioning

confidence: 99%

Industrial Production of Superoxide Dismutase (SOD): A Mini Review

Gopal¹,

Elumalai²

2017

J Prob Health

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“…The cells contains endogenous enzymes as superoxide dismutase, glutathione peroxidase and catalase to convert toxic forms of oxygen into molecular oxygen and water, but these functions are exceeded when the cells liberate these radicals in to the extracellular space, since the extracellular SOD is usually found in very low concentrations. [15] Recent studies demonstrate that this cycle of toxicity can be stopped by the administration of exogen superoxide dismutase (Orgoteína/Ontosein) eliminating the extracellular superoxide radicals and allowing to reduce the consequence of inflammatory effects. [15,16] Several experimental strategies have been used to address the importance of the enhanced production of superoxide in the pathogenesis or bowel diseases, but inconsistent findings have left this issue largely unresolved.…”

Section: Wwwantioxorgmentioning

confidence: 99%

“…[15] Recent studies demonstrate that this cycle of toxicity can be stopped by the administration of exogen superoxide dismutase (Orgoteína/Ontosein) eliminating the extracellular superoxide radicals and allowing to reduce the consequence of inflammatory effects. [15,16] Several experimental strategies have been used to address the importance of the enhanced production of superoxide in the pathogenesis or bowel diseases, but inconsistent findings have left this issue largely unresolved. Therefore, further investigation about the effects of SOD on bowel diseases seems warranted, especially elucidating the value of this therapeutic approach in established bowel alterations in diabetes mellitus.…”

Section: Wwwantioxorgmentioning

confidence: 99%

Superoxide Dismutase Ameliorates the Bowel Alterations Induced by Diabetes Mellitus – An Experimental Study

Fillmann

Tieppo

Filho

et al. 2011

Free Radicals and Antioxidants

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Introduction: The gastrointestinal system is frequently affected in patients with diabetes mellitus (DM). Some of these alterations are due to oxidative stress and the production of free radicals. The present study was designed to evaluate whether treatment with superoxide dismutase (SOD) exerts protection on established bowel alterations in experimental diabetes mellitus induced by streptozotocin. We measured the lipid peroxidation, the superoxide dismutase activity and the DNA damage. Materials and Methods: We used the anorectal pressure to evaluate the nitrosative stress and used an inflammatory score to measure the macroscopic and microscopic bowel alterations. Results: The oxidative stress and the DNA damage was elevated in DM group and reduced with the SOD administration. The use of SOD also ameliorates the inflammatory bowel alterations and the anorectal pressure. Conclusion: SOD administration showed beneficial effects in all parameters of large bowel alterations in DM rats. IntroductIonDiabetes mellitus is a metabolic endocrine disorder that affects many systems. The complications may arise in several organs in different moments and situations, the gastrointestinal often being among the affected systems. Diabetes mellitus is one of the most common metabolic diseases, affecting about 2.5-3% of the world's population and 7% or more in some countries.[1] A considerable amount of evidence suggests that oxidative stress may play an important role in the pathogenesis and complications of diabetes. Different mechanisms can contribute to the enhanced oxidative stress in diabetic patients, in particular in subjects with poor glycaemic control and hypertriglyceridaemia.[2] Diabetic patients may have reduced antioxidant defenses, such as diminished activity of glutathione peroxidase, catalase and superoxide dismutase, as well as decreased levels of non-enzymatic antioxidants. In consequence, they may suffer from an increased risk of oxidative stress-related diseases, Hospital Clínic. University of Barcelona, Spain including atherosclerosis, the most common reason for premature death. [3] The accumulation of oxidative stress products can cause damage to biological molecules: proteins, lipids and DNA. The production of reactive oxidative species (ROS) is elevated in diabetes, particularly among those who have poor glycaemic control. It has been hypothesized that increased ROS generation in longstanding diabetes may result in oxidative damage to DNA. Studies with comet assay have shown increased levels of DNA breakage in peripheral blood cells of type I diabetic patients with poor glycaemic control, but not in patients with normal glycaemia. [4,5] Dinçer et al. found increased strain breakage and formamidopyrimidine DNA glycosylase (Fpg)-sensitive sites by the comet assay in DNA from leukocytes of patients with type I diabetes. [6] Lipid peroxidation of cellular structures, a consequence of free radical activity, is thought to play an important role in late complications of diabetes mellitus. [2,7]

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“…La inhibición de estos radicales mediante dismutadores de ellos podría beneficiar a estos pacientes como se han demostrado en otras localizaciones 20,21 . En piel se han publicado resultados con Theta crem 22 , que contiene como antioxidante C M Glucan, sin que en la serie de 20 pacientes se hallan encontrado diferencias estadística-mente significativas.…”

Section: Antiestrés Oxidativounclassified

Toxicidad de piel: prevencion y tratamiento

Escó¹,

Valencia²,

Polo³

et al. 2005

Oncología (Barc.)

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IntroducciónActualmente la toxicidad cutánea por irradiación está disminuyendo por los avances técnicos que se han dado en el campo de la radioterapia, tales como energías altas cuya zona de equilibrio electrónico se encuentra en muchos casos, no sólo a milímetros, sino a centímetros de profundidad, así como por la utilización de modernas técnicas de planificación, que permiten utilizar múltiples puertas de entrada y de esta manera repartir la dosis que pueda recibir la piel. No obstante, la piel sigue siendo la puerta de entrada de toda radiación y por tanto el primer lugar de agresión.Por otro lado, los oncólogos radioterápicos siempre hemos intentado cuidar la piel al máximo, pues si bien, en general, la toxicidad cutánea no es especialmente grave, es molesta para el paciente. Prevención o tratamientoA la hora de plantear el cuidado de la piel, la primera pregunta que debemos hacernos es si existe prevención efectiva o si debemos esperar a que aparezcan los efectos secundarios y entonces tratarlos.Si revisamos la bibliografía referente a toxicidad cutánea y su manejo, vemos que, en general, durante los años 50-70 los artículos publicados eran de tratamientos de la toxicidad ya establecida. Igualmente estos primeros trabajos usaban corticoides y eran observacionales. Los pocos comparativos comparaban eficacia de 2 corticoides, pues se daba por hecho que el tratamiento de la lesión cutánea se realizaba mediante el empleo de corticoterapia tópica.En las dos últimas décadas prácticamente todos los artícu-los publicados se refieren al empleo de diversos agentes para prevenir la toxicidad cutánea y al ser trabajos de prevención todos deben ser randomizados, en los que se compara la efectividad de diversos productos, fundamentalmente sustancias emolientes, (son sustancias blandas grasas u oleosas que hidratan y suavizan la piel, son oclusivas y suelen contener parafina), en general frente a placebo, para verificar la capacidad de ellos para evitar, retrasar o disminuir el grado de lesión cutánea radioinducida.Por ello, parece claro que la tendencia actual es a prevenir la toxicidad cutánea. Tratamiento de la dermitis por irradiación CorticoidesEn el tratamiento de la dermitis por irradiación se han usado fundamentalmente los corticoides tópicos. Su mecanismo de acción es a nivel de la reacción inflamatoria que en la dermis se produce como consecuencia del depósito de energía que la radiación produce. Esta energía induce cambios consistentes en vasodilatación, con aparición de enrojecimiento, aumento de la permeabilidad vascular, proliferación de leucocitos y facilitación de su migración. Los corticoides actúan a estos cuatro niveles con reducción de la vasodilatación, lo que condiciona una reducción de la permeabilidad capilar, inhibición de la proliferación leucocitaria y de su migración.Los primeros trabajos datan de 1954 y son de Houghton 1 y posteriormente en 1965 de Björnberg 2 . En 1979, Gless 3 presenta un ensayo en el que randomiza a 54 pacientes, la mitad se tratan con hidrocortisona y la otra mitad con clo...

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Efficacy of orgotein in prevention of late side effects of pelvic irradiation: A randomized study

Cited by 28 publications

References 8 publications

Industrial Production of Superoxide Dismutase (SOD): A Mini Review

Industrial Production of Superoxide Dismutase (SOD): A Mini Review

Superoxide Dismutase Ameliorates the Bowel Alterations Induced by Diabetes Mellitus – An Experimental Study

Toxicidad de piel: prevencion y tratamiento

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