Efficacy of Orlistat as an Adjunct to Behavioral Treatment in Overweight African American and Caucasian Adolescents with Obesity-related Co-morbid Conditions

McDuffie, Jennifer R; Calis, Karim A.; Uwaifo, Gabriel I.; Sebring, Nancy G.; Fallon, Erica M.; Frazer, Teresa; Hubbard, Van S.; Yanovski, Jack A.

doi:10.1515/jpem.2004.17.3.307

Cited by 86 publications

(55 citation statements)

References 73 publications

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“…In another uncontrolled study, a 4 kg weight loss was reported in 11 prepubertal children within 3 months [8]. A follow-up of former study was recently published demonstrating similar results at 6 months of treatment [7]. There are no medium-term studies published in paediatric population regarding efficacy and tolerability of orlistat.…”

Section: Discussionmentioning

confidence: 99%

Addition of orlistat to conventional treatment in adolescents with severe obesity

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Addition of orlistat to conventional treatment in adolescents with severe obesity

et al. 2004

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“…It has been shown to have modest weight loss efficacy in obese children and adolescents. [183][184][185][186][187] The largest study (n=539) of orlistat in obese adolescents reported a placebo-subtracted reduction in BMI of 0.86 kg/m 2 (BMI reduction of ≈2.4%) over a treatment period of 1 year. 183 No cardiometabolic benefits were observed other than a small reduction in diastolic blood pressure.…”

Section: Orlistatmentioning

confidence: 99%

Severe Obesity in Children and Adolescents: Identification, Associated Health Risks, and Treatment Approaches

Kelly¹,

Barlow

Rao³

et al. 2013

Circulation

898

804

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espite recent data suggesting that the rate of increase of obesity among children and adolescents has slowed and overall prevalence has possibly begun to plateau, 1,2 a worrisome trend has emerged in the form of severe pediatric obesity. As the fastest-growing subcategory of obesity in children and adolescents, 1,3,4 severe obesity afflicts between 4% and 6% of all youth in the United States 3-7 and has both immediate and long-term health consequences. Recent data further Abstract-Severe obesity afflicts between 4% and 6% of all youth in the United States, and the prevalence is increasing.Despite the serious immediate and long-term cardiovascular, metabolic, and other health consequences of severe pediatric obesity, current treatments are limited in effectiveness and lack widespread availability. Lifestyle modification/behaviorbased treatment interventions in youth with severe obesity have demonstrated modest improvement in body mass index status, but participants have generally remained severely obese and often regained weight after the conclusion of the treatment programs. The role of medical management is minimal, because only 1 medication is currently approved for the treatment of obesity in adolescents. Bariatric surgery has generally been effective in reducing body mass index and improving cardiovascular and metabolic risk factors; however, reports of long-term outcomes are few, many youth with severe obesity do not qualify for surgery, and access is limited by lack of insurance coverage. To begin to address these challenges, the purposes of this scientific statement are to (1) provide justification for and recommend a standardized definition of severe obesity in children and adolescents; (2) raise awareness of this serious and growing problem by summarizing the current literature in this area in terms of the epidemiology and trends, associated health risks (immediate and long-term), and challenges and shortcomings of currently available treatment options; and (3) highlight areas in need of future research. Innovative behavior-based treatment, minimally invasive procedures, and medications currently under development all need to be evaluated for their efficacy and safety in this group of patients with high medical and psychosocial risks. (Circulation. 2013;128:1689-1712.)

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“…На фоне лечения подростки снизили вес в среднем на 8,7±1,2%, жен-щины -на 13,6±4,2% от исходных значений. В обеих группах шло улучшение антропометрических показа-телей и нормализация липидного спектра крови, на что также указывают большинство исследователей, приме-нявших орлистат, как у взрослых [6,14,20], так и у под-ростков [12,16,18].…”

Section: результаты исследования и их обсуждениеunclassified

“…Пять подростков отказались от лечения на I этапе из-за развившихся у них побочных эффек-тов. Такую же реакцию у подростков наблюдали прак-тически все исследователи, применявшие орлистат для лечения ожирения в этой возрастной группе [12,16,18], что объясняется сниженной мотивацией к про-водимому лечению и отсутствием у детей подростко-вого возраста полного представления о ценности своего здоровья [5].…”

Section: результаты исследования и их обсуждениеunclassified

Narusheniya menstrual'nogo tsikla u podrostkovi molodykh zhenshchin s ozhireniem

Кузнецова¹,

Mikhaelyants²,

Santa-Mariya-Fernandes³

et al. 2010

Obes. metabol.

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Obesity plays a key role in reproductive disorders. Xenical administration results in recovery of menstrual function in 78.9% and ovulation in 26.3% of patients with obesity. Hormone therapy in patients with obesity should be accompanied with Xenical therapy, which has a favorable impact on further body weight reduction (13.95% from baseline) and improvement (or stability) of metabolic parameters.

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Efficacy of Orlistat as an Adjunct to Behavioral Treatment in Overweight African American and Caucasian Adolescents with Obesity-related Co-morbid Conditions

Cited by 86 publications

References 73 publications

Addition of orlistat to conventional treatment in adolescents with severe obesity

Addition of orlistat to conventional treatment in adolescents with severe obesity

Severe Obesity in Children and Adolescents: Identification, Associated Health Risks, and Treatment Approaches

Narusheniya menstrual'nogo tsikla u podrostkovi molodykh zhenshchin s ozhireniem

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