Efficacy of oxitard capsules in the treatment of oral submucous fibrosis

Patil, Santosh; Santosh, BS; Maheshwari, Sneha; Deoghare, Abhijeet; Chhugani, Satish; Rajesh, PR

doi:10.4103/0973-1482.136023

Cited by 20 publications

(17 citation statements)

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“…Various studies are stated in literature with significant mean improvement in mouth opening using levamisole (2.9 mm), micronutrients (2.9 mm), antoxid (3.1 mm), intralesional hydrocortisone with hyaluronidase and lycopene (3.4 mm and 5.38 mm), pentoxifylline with garlic pearls (5 mm), turmeric with tulsi (3-4 mm), turmeric with black pepper (3.8 mm), and intralesional dexamethasone with placental extract (3.5 mm) which is in favor of our study while studies published using intralesional INF-gamma (8 mm) and oxitard (12 mm) have shown better results. [7,13,14,[20][21][22][23][24][25][26][27][28] The present study with isometric exercises is in consonance with the studies published on micronutrients with isometric exercises (3.1 mm), tongue blade (3.1 mm), and ultrasound (3.74 mm) and better results were shown in dynasplint (7 mm) and Therabite (10 mm). [21,[29][30][31] The mean increment in tongue protrusion and cheek flexibility was 2.4 mm and 0.7 mm, respectively, which was comparable with topical Aloe vera gel, turmeric and black pepper, Nigella sativa, and pentoxifylline together.…”

Section: Discussionsupporting

confidence: 84%

Efficacy of spirulina with isometric exercises in the management of oral submucous fibrosis

Kanjani¹,

Annigeri²,

Revanappa³

2018

JCRI

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Background: Oral submucous fibrosis (OSMF) is a chronic inflammatory, potentially malignant oral disorder. Spirulina with its antioxidant, anti-inflammatory, and immunomodulating properties has shown promising results in the management of OSMF. Few studies involving isometric exercises are stated in literature as physiotherapy modalities for OSMF. Aim: This study aims to evaluate the efficacy of spirulina with isometric exercises in the management of OSMF. Materials and Methods: A study consisted of 15 clinically diagnosed OSMF patients. All patients were given spirulina 500 mg twice a day for 3 months. Patients were instructed to perform isometric mouth exercises for 20 min, twice daily. Patients were evaluated every 15 days for the assessment of clinical parameters. Results were analyzed with SPSS software. Results: There was a significant reduction in burning sensation (59%) and increment of 3.2 mm in mouth opening with P = 0.001. The present study also showed significant improvement in cheek flexibility and tongue protrusion (P < 0.05). Conclusion: Spirulina along with isometric exercises was well tolerated by patients. All the clinical parameters (burning sensation, mouth opening, tongue protrusion, and cheek flexibility) showed a statistically significant improvement. Thus, the present combined modality was non-invasive, cost-effective, and beneficial in the management of OSMF.

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Section: Discussionsupporting

confidence: 84%

Efficacy of spirulina with isometric exercises in the management of oral submucous fibrosis

Kanjani¹,

Annigeri²,

Revanappa³

2018

JCRI

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“…Chemopreventive Effects of Nutrient Antioxidants as a Potential OSMF Treatment A total of 26 clinical studies and one dual study [8] supported the chemoprotective role of antioxidant supplementation. Clinical improvements in at least one OSMF symptom (mouth opening, mucosal burning sensation, tongue protrusion, cheek flexibility, difficulty in swallowing and speech, pain associated with the lesion, oral health-related quality of life) were observed after administration of lycopene [57][58][59][60][61][62][63][64][65], alpha-lipoic acid [66], allicin [67], rebamipide [68], pentoxifylline [69,70], oxitard [59,71,72], aloe vera [71,[73][74][75][76][77], curcumin [77][78][79][80][81], and spirulina [75,82] (Table 2).…”

Section: Clinical Studiesmentioning

confidence: 99%

“…When compared to standard antioxidant capsules, aloe vera produced greater improvements in burning sensation and mouth opening [74], while pentoxifylline showed further reduction in dysphagia and burning sensation [69]. Aloe vera was less effective in improving mouth opening when compared to spirulina [75], and also less effective in improving swallowing, speech, and pain associated with the lesion when compared with oxitard capsules [71]. However, when compared to curcumin, aloe vera brought larger improvements in burning sensation, but the two were equally effective in increasing mouth opening [77].…”

Section: Chemopreventive Effects Of Nutrient Antioxidants As An Effic...mentioning

confidence: 99%

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.

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“…OSMF presents clinically as blanching of the oral mucosa, burning sensation, ulceration, pain, decreased mobility and depapillation of the tongue, depigmentation of the oral mucosa, and progressive reduction of mouth opening. Severe cases of OSMF presents with nasal twang due and difficulty in hearing [5,6].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Maximum Bite Force in Oral Submucous Fibrosis Patients: A Preliminary Study

Patil

Maragathavalli

Ramesh³

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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To determine the maximum bite force (MBF) in oral submucous fibrosis (OSMF) patients and to compare them with that of healthy subjects. Material and Methods: Twenty patients who were clinically confirmed, as OSMF and 20 healthy controls matched for age, gender, and number of intact functional teeth were included in this study. For each subject, age, gender, weight, height and body mass index (BMI) were recorded. The MBF registration was carried out by the two evaluators, who were previously calibrated. Bite force was measured in the first molar region using a force transducer occlusal force meter for each subject seated at the upright position, with Frankfort's plane nearly parallel to the floor, and no head support. The Student's independent t-test was used to determine the statistical significance in relation to mean height, weight, BMI and the presence of number of intact teeth and MBF between the healthy subjects and OSMF individuals. A comparison of grades of OSMF with all variables was carried out by one-way ANOVA test. Results: No significant difference was found in mean age, mean height, weight, BMI and the presence of the number of intact teeth between healthy individuals and OSMF patients. The mean MBF in healthy subjects was 628.23 ± 24.39 N and 635.47 ± 31.22 N in OSMF patients. Even though the healthy subjects reported a higher MBF than OSMF patients did, the difference was statistically non-significant. With regards to sides, no significant difference was observed in mean MBF in healthy subjects and OSMF patients on the right (p=0.7818) and left side (p=0.6154). Conclusion: The healthy subjects reported higher MBF values than OSMF patients did and the difference was statistically non-significant.

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Efficacy of oxitard capsules in the treatment of oral submucous fibrosis

Cited by 20 publications

References 0 publications

Efficacy of spirulina with isometric exercises in the management of oral submucous fibrosis

Efficacy of spirulina with isometric exercises in the management of oral submucous fibrosis

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Assessment of Maximum Bite Force in Oral Submucous Fibrosis Patients: A Preliminary Study

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