Efficacy of Oxymatrine Plus Antiviral in the Treatment of Sepsis and Its Effect on the Levels of Endotoxin and Inflammatory Factors

Zhao, Jinglin; Wei, Qi; Guo, Shengchao; Wang, Hao; Zhao, Chunjiang; Hu, Changwei; Liu, Cuicui; Dai, Qingchun; Wang, Rui

doi:10.1155/2022/1938325

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Sophora flavescens belongs to the leguminous family and is a perennial shrub that is mainly grown in China (Huang et al, 2014). Matrine (MAT), a quinolizidine alkaloid isolated from the roots of S. flavescens , exerts anti‐inflammatory, antioxidative, and protective effects against sepsis‐induced tissue damage (Sun et al, 2012; Xu et al, 2016; Zhao et al, 2022). Oxymatrine (OMT) is the oxidized product of MAT and has higher pharmacological activity than MAT.…”

Section: Introductionmentioning

confidence: 99%

Oxymatrine attenuates sepsis‐induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF‐κB signaling pathway

He,

Qin,

Jiang

et al. 2024

Drug Development Research

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Sepsis is a life‐threatening organ dysfunction that endangers patient lives and is caused by an imbalance in the host defense against infection. Sepsis continues to be a significant cause of morbidity and mortality in critically sick patients. Oxymatrine (OMT), a quinolizidine alkaloid derived from the traditional Chinese herb Sophora flavescens Aiton, has been shown to have anti‐inflammatory effects on a number of inflammatory illnesses according to research. In this study, we aimed to evaluate the therapeutic effects of OMT on sepsis and explore the underlying mechanisms. We differentiated THP‐1 cells into THP‐1 macrophages and studied the anti‐inflammatory mechanism of OMT in a lipopolysaccharide (LPS)‐induced THP‐1 macrophage sepsis model. Activation of the receptor for advanced glycation end products (RAGE), as well as NF‐κB, was assessed by Western blot analysis and immunofluorescence staining. ELISA was used to measure the levels of inflammatory factors. We found that OMT significantly inhibited HMGB1‐mediated RAGE/NF‐κB activation and downstream inflammatory cytokine production in response to LPS stimulation. Finally, an in vivo experiment was performed on septic mice to further study the effect of OMT on injured organs. The animal experiments showed that OMT significantly inhibited HMGB1‐mediated RAGE/NF‐κB activation, protected against the inflammatory response and organ injury induced by CLP, and prolonged the survival rate of septic mice. Herein, we provide evidence that OMT exerts a significant therapeutic effect on sepsis by inhibiting the HMGB1/RAGE/NF‐κB signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Oxymatrine attenuates sepsis‐induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF‐κB signaling pathway

He,

Qin,

Jiang

et al. 2024

Drug Development Research

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“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”

mentioning

confidence: 99%

Retracted: Efficacy of Oxymatrine Plus Antiviral in the Treatment of Sepsis and Its Effect on the Levels of Endotoxin and Inflammatory Factors

and Alternative Medicine

2023

Evidence-Based Complementary and Alternative Medicine

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Identification of common core genes and pathways of sepsis and cancer by bioinformatics analysis

He,

Ding,

Han

et al. 2024

Preprint

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Introduction Both sepsis and cancer are leading causes of death worldwide, and they share a number of pathophysiological features. Some studies have suggested a possible association between sepsis and cancer, but few have studied core genes in both diseases. Methods Common core genes were identified from sepsis datasets (GEO: GSE26378, GSE4607, GSE8121 and GSE13904) and cancer databases (TCGA: BRCA, COADREAD, ESCA, KIRC, LIHC, LUAD, STAD). Then, GO and Reactome enrichment analyses and PPI network analysis were performed. Pharmacophore screening was used to predict the targetsof oxymatrine and ulinastatin,and potential target genes in both cancer and sepsis were obtained. Survival analysis was performed. The association between the target genes and tumor size and number of positive lymph nodes was investigated by Pearson correlation analysis. The association between the target genes and tumor stage was investigated by Fisher’s exact test. Molecular docking analysis was performed to evaluate the affinity of the candidate drugs for their targets. Results In total, 641 common genes were identified. GO enrichment analysis showed that common genes were enriched in neutrophil degranulation, inflammatory response and innate immune response. Reactome enrichment analysis showed that common genes were enriched in neutrophil degranulation, interleukin-4 and interleukin-13 signaling, transcriptional regulation of granulopoiesis and interleukin-10 signaling. The PPI network showed that the top 10 core genes were TLR4, IL1B, IL10, ITGAM, TLR2, PTPRC, CDK1, FOS, MMP9 and ITGB2. The survival analysis showed that the high expression of BCAT1, CSAD, G6PD, GM2A, MMP9, PYGL and TOP2A was associated with poorer prognosis in several cancers. Molecular docking showed that oxymatrine and ulinastatin can bind to protein targets with highly stable binding. Conclusions We identified genes with common effects on both sepsis and cancer, which provides new insights into the association between sepsis and cancer. In addition, two drugs with potential clinical application value were identified. Further studies are required to validate the role of these common core genes in sepsis and cancer and to evaluate the potential utility of these drugs.

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Efficacy of Oxymatrine Plus Antiviral in the Treatment of Sepsis and Its Effect on the Levels of Endotoxin and Inflammatory Factors

Cited by 3 publications

References 25 publications

Oxymatrine attenuates sepsis‐induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF‐κB signaling pathway

Oxymatrine attenuates sepsis‐induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF‐κB signaling pathway

Retracted: Efficacy of Oxymatrine Plus Antiviral in the Treatment of Sepsis and Its Effect on the Levels of Endotoxin and Inflammatory Factors

Identification of common core genes and pathways of sepsis and cancer by bioinformatics analysis

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