Efficacy of ozone therapy on visual evoked potentials in diabetic patients

Abstract

Background The involvement of the central nervous system is a frequent yet underestimated complication of diabetes mellitus. Visual evoked potentials (VEP) are a simple, sensitive, and noninvasive method for detecting early alterations in central optic pathways. The objective of this paralleled randomized controlled trial was to evaluate the impact of ozone therapy on visual pathways in diabetic patients. Methods Sixty patients with type 2 diabetes visiting clinics of Baqiyatallah university in Tehran (Iran) hospital were randomly assigned to two experimental groups: Group 1 (N = 30) undergoing a cycle of 20 sessions of systemic oxygen-ozone therapy in addition to standard therapy for metabolic control; Group 2 (N = 30)—serving as control—receiving only standard therapy against diabetes. The primary study endpoints were two VEP parameters; P100 wave latency and P100 amplitude at 3 months. Moreover, HbA1c levels were measured before the start of treatment and three months later as secondary study endpoint. Results All 60 patients completed the clinical trial. P100 latency significantly reduced at 3 months since baseline. No correlation was found between repeated measures of P100 wave latency and HbA1c (Pearson’s r = 0.169, p = 0.291). There was no significant difference between baseline values and repeated measures of P100 wave amplitude over time in either group. No adverse effects were recorded. Conclusions Ozone therapy improved the conduction of impulses in optic pathways of diabetic patients. The improved glycemic control following ozone therpay may not fully explain the reduction of P100 wave latency though; other mechanistic effects of ozone may be involved.

Correction: Efficacy of ozone therapy on visual evoked potentials in diabetic patients

“…Correction: Efficacy of ozone therapy on visual evoked potentials in diabetic patients Morteza Izadi 1 , Mohammad Javanbakht 2* , Ali Sarafzadeh 3* , Behzad Einollahi 2 , Farzaneh Futuhi 4 , Zahra Vahedi 5 , Shi Zhao 6 , Nematollah Jonaidi-Jafari 1 , Mahboobeh Sadat Hosseini 7 , Javad Hosseini Nejad 8 , Effat Naeimi 9 , Seyed Hassan Saadat 10 , Hadi Esmaeili Gouvarchin Ghaleh 11 , Mozhgan Fazel 12 , Zahra Einollahi 13 Following the publication of the original article [1], it was noted that due to a typesetting error the affiliation of both the authors were wrongly placed. The correct affiliations are provided in this correction and the original article has been corrected.…”

Electrophysiological characteristics of experimental diabetes under the conditions of using niacin-oxy-ethylidene-diphosphonate germinate (MIGU-4)

“…Visual-evoked potentials (VEPs) are one of the most informative criteria of the functional state of visual pathways, and characteristic VEPs are pertinent for DR (Saadoun et al, 2020;Izadi et al, 2023). Increases in P100 latency and the reduction of N75-P100 amplitudes were demonstrated in patients with type I and type II diabetes mellitus (Pescosolido et al, 2015;Khatoon et al, 2016;Kumari et al, 2020).…”