Efficacy of parenteral S-adenosylmethionine (SAMe) in a case of intrahepatic cholestasis (IHC) induced by total parenteral nutrition (TPN)

Plasencia, Antonio Ma Caballero; García, Mireya; Torres, Ana Isabel; P, Ortiz; Bortolini, M.

doi:10.1016/0168-8278(91)91389-x

Journal of Hepatology

1991

DOI: 10.1016/0168-8278(91)91389-x

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Efficacy of parenteral S-adenosylmethionine (SAMe) in a case of intrahepatic cholestasis (IHC) induced by total parenteral nutrition (TPN)

Antonio Ma Caballero Plasencia¹,

Mireya García²,

Ana Isabel Torres³

et al.

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2019

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“…S-adenosyl synthetase reaction. A decrease in its operating time, which leads to a depletion of the cysteine pool, not only exacerbates the negative nitrogen balance that develops as a result of liver dysfunction, but also prevents detoxification reactions [27][28][29][30][31]. The latter, as is known, are associated with transmethylation processes in which S-adenosylmethionine plays the role of a donor of CH3 groups, and with the formation of glutathione, the synthesis of which requires cysteine [32][33][34][35].…”

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Amino Acids and Their Derivatives in Pathogenesis and Treatment of Liver Diseases (Mini-Review)

Nefyodov¹,

et al. 2019

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A mini review of literature data on the mechanisms of formation of the stock of free amino acids and their derivatives in liver pathology and methods for correcting metabolic imbalance.The importance of amino acids in the biosynthesis of protein and highly active biological compounds was the main prerequisite for numerous studies of their content in body fluids and tissues in a wide variety of experimental and pathological situations. In the intermediate metabolism of amino acids and their derivatives, a connecting role is played by in the integration of the main metabolic flows [1][2][3][4]. The pool of free amino acids is represented by a rich set of metabolically and functionally interconnected compounds, with the concentrations being a regulatory factor at many key steps of metabolism [5,6].In connection with the foregoing, study of the mechanisms of formation of the free amino acid pool in vivo is part of the most important problem of contemporary biochemistry and clinical medicine associated with targeted regulation of metabolic processes in the human body by biologically active natural compounds.Currently, the number of patients with pathology continues to grow, with metabolic disorders playing a leading role in the genesis of these pathologic states [4][5][6]. The most urgent in this case is the problem of the pathogenetic role of disorders in the metabolism of amino acids in hepatobiliary pathology, as well as the optimization of the use of individual amino acids or their artificial mixtures not only for replacement therapy, but also for targeted metabolic correction of liver diseases [6][7][8][9][10][11][12][13][14][15][16][17]. In addition to disturbances in the chain of reactions of carbohydrate, lipid and protein metabolisms characteristic of liver damage, a pronounced amino acid imbalance is observed in physiological fluids and tissues [18][19][20].Thus, it was shown that an increase in blood methionine level and a decrease in its excretion during exogenous loads with this amino acid clearly correlate with clinical manifestations of diseases accompanied by impaired liver function [21][22][23][24]. In addition, the blood of patients with liver damage shows a decrease in the concentration of the most important methionine degradation product, cysteine, and a dramatic increase in the toxicity of methionine [25,26]. Normally, up to 10 g of S-adenosylmethionine

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Amino Acids and Their Derivatives in Pathogenesis and Treatment of Liver Diseases (Mini-Review)

Nefyodov¹,

et al. 2019

BJSTR

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Amino Acids and their Derivatives in Pathogenesis and Treatment of Liver Diseases

Nefyodov

Karakosh

Alufaini

et al. 2019

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Efficacy of parenteral S-adenosylmethionine (SAMe) in a case of intrahepatic cholestasis (IHC) induced by total parenteral nutrition (TPN)

Cited by 2 publications

References 0 publications

Amino Acids and Their Derivatives in Pathogenesis and Treatment of Liver Diseases (Mini-Review)

Amino Acids and Their Derivatives in Pathogenesis and Treatment of Liver Diseases (Mini-Review)

Amino Acids and their Derivatives in Pathogenesis and Treatment of Liver Diseases

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