Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV

Niborski, Violeta; Li, Y.; Brennan, F.; Lane, Majella E.; Torché, Anne-Marie; Remond, Michèle; Bonneau, Michel; Riffault, Sabine; Stirling, Catrina; Hutchings, G.; Takamatsu, H.; Barnett, P.V.; Charley, Bernard; Schwartz-Cornil, Isabelle

doi:10.1016/j.vaccine.2006.06.048

Cited by 34 publications

(13 citation statements)

References 26 publications

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“…If using gene gun-based mucosal DNA immunization against Visna-Maedi in sheep, the plasmid expressing the envelope gene of the virus in combination with IFNγ gene, is expected to give significant protection and also could restrict virus replication. For preventing FMD infection, Niborski et al (2006) reported the development of a VP1-based nucleic acid vaccine and found that it was more effective when used along with poly lactide co-galactide (PLG) formulation. Against rift valley fever, the viral glycoprotein gene of Rift valley fever virus (RVFV) when used as DNA vaccine have been found to induce neutralizing antibodies during experimental studies.…”

Section: Applications Of Nucleic Acid Vaccines In Veterinary Practicementioning

confidence: 99%

DNA vaccines and their applications in veterinary practice: current perspectives

et al. 2008

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Inoculation of plasmid DNA, encoding an immunogenic protein gene of an infectious agent, stands out as a novel approach for developing new generation vaccines for prevention of infectious diseases of animals. The potential of DNA vaccines to act in presence of maternal antibodies, its stability and cost effectiveness and the non-requirement of cold chain have heightened the prospects. Even though great strides have been made in nucleic acid vaccination, still there are many areas that need further research for its wholesome practical implementation. Major areas of concern are vaccine delivery, designing of suitable vectors and cytotoxic T cell responses. Also, the induction of immune responses by DNA vaccines is inconclusive due to the lack of knowledge regarding the concentration of the protein expressed in vivo. Alternative delivery systems having higher transfection efficiency and the use of cytokines, as immunomodulators, needs to be further explored. Recently, efforts are being made to modulate and prolong the active life of dendritic cells, in order to make antigen presentation a more efficacious one. For combating diseases like acquired immunodeficiency syndrome (AIDS), influenza, malaria and tuberculosis in humans; and foot and mouth disease, Aujesky's disease, swine fever, rabies, canine distemper and brucellosis in animals, DNA vaccine clinical trials are underway. This review highlights the salient features of DNA vaccines, and measures to enhance their efficacy so as to devise an effective and novel vaccination strategy against animal diseases.

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Section: Applications Of Nucleic Acid Vaccines In Veterinary Practicementioning

confidence: 99%

DNA vaccines and their applications in veterinary practice: current perspectives

et al. 2008

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“…Therefore, a simplified immunotherapy with a reduced number of injections would be highly advantageous since it would improve patient compliance and provide socioeconomic benefits. Here, biodegradable materials, such as PLGA, represent a potential therapeutic alternative [24][25][26]. While particulate childhood vaccines failed mainly owing to the already available alternatives and particulate cytotoxic T-cell vaccines might fail due to low efficacy compared with other technologies under development, it is our opinion that biodegradable microparticle technology may have a realistic chance of success for allergy vaccines.…”

Section: Allergy Vaccinesmentioning

confidence: 99%

Development of synthetic biodegradable microparticulate vaccines: a roller coaster story

Johansen

Gómez

Gander

2007

Expert Review of Vaccines

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“…Gamma rays can penetrate through all materials, excepting some such as lead (Pb), without any residues; therefore, there is no risk of an irradiated inactivated viral vaccine escaping. In addition, the duration of the viral inactivation process by gamma radiation is shorter than the time needed for chemical inactivation [7]. The inactivation of viruses by ionizing radiation shows that a single ionization is sufficient to inactivate a single virus particle.…”

Section: Introductionmentioning

confidence: 99%

Development of Protective Immunity against Inactivated Iranian Isolate of Foot-and-Mouth Disease Virus Type O/IRN/2007 Using Gamma Ray-Irradiated Vaccine on BALB/c Mice and Guinea Pigs

Motamedi-Sedeh

Soleimanjahi²,

Jalilian³

et al. 2015

Intervirology

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Objectives: Foot-and-mouth disease virus (FMDV) causes a highly contagious disease in cloven-hoofed animals and is the most damaging disease of livestock worldwide, leading to great economic losses. The aim of this research was the inactivation of FMDV type O/IRN/1/2007 to produce a gamma ray-irradiated (GRI) vaccine in order to immunize mice and guinea pigs. Methods: In this research, the Iranian isolated FMDV type O/IRN/1/2007 was irradiated by gamma ray to prepare an inactivated whole virus antigen and formulated as a GRI vaccine with unaltered antigenic characteristics. Immune responses against this vaccine were evaluated on mice and guinea pigs. Results: The comparison of the immune responses between the GRI vaccine and conventional vaccine did not show any significant difference in neutralizing antibody titer, memory spleen T lymphocytes or IFN-γ, IL-4, IL-2 and IL-10 concentrations (p > 0.05). In contrast, there were significant differences in all of the evaluated immune factors between the two vaccinated groups of mice and negative control mice (p < 0.05). The protective dose 50 for the conventional and GRI vaccines obtained were 6.28 and 7.07, respectively, which indicated the high potency of both vaccines. Conclusion: GRI vaccine is suitable for both routine vaccination and control of FMDV in emergency outbreaks.

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Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV

Cited by 34 publications

References 26 publications

DNA vaccines and their applications in veterinary practice: current perspectives

DNA vaccines and their applications in veterinary practice: current perspectives

Development of synthetic biodegradable microparticulate vaccines: a roller coaster story

Development of Protective Immunity against Inactivated Iranian Isolate of Foot-and-Mouth Disease Virus Type O/IRN/2007 Using Gamma Ray-Irradiated Vaccine on BALB/c Mice and Guinea Pigs

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