Efficacy of pazufloxacin mesilate in Legionnaires’ disease: a case report and in vitro study of the isolate

In vivo efficacy of sivelestat in combination with pazufloxacin againstLegionellapneumonia

“…pneumophila is very susceptible to several antibiotics, such as the fluoroquinolones, ketolides and macrolides [14]. Pazufloxacin, a fluoroquinolone antibiotic available in Japan, is also effective against Legionella [19,23]. In this study, pazufloxacin showed slight decrease of the number of viable bacteria, however, the combination therapy showed more effective for decreasing of bacteria with a significant difference in spite of the short duration of treatment.…”

Legionella pneumonia caused by Legionella pneumophila serogroup 2: second case report in Japan

“…[17][18][19][20] This case confi rmed the effi cacy of intravenous fl uoroquinolones in pneumonia due to L. pneumophila SG 2 in combination with a macrolide. The combination therapy of CPFX and a macrolide was reported to be effective during an in vitro study, 21 which warranted further study.…”

Severe Legionnaires' Disease Successfully Treated Using a Combination of Fluoroquinolone, Erythromycin, Corticosteroid, and Sivelestat

“…We successfully treated the patient with severe Legionella pneumonia with ARDS using a combination of fluoroquin- ' s c l i n i c a l c o u r s (9) (12). Recently, a randomized, controlled study found that chronic, low-dose corticosteroid therapy was effective in patients with severe communityacquired pneumonia (13) (17), and bleomycin-induced fibrosis (18).…”