Efficacy of pectins with different degrees of methyl-esterification and of blockiness in preventing gut epithelial cell barrier disruption and the impact on sodium–glucose co-transporter expression under low and high glucose conditions

Tang, Xiaohu; Beukema, Martin; Ferrari, Michela; Walvoort, Marthe T. C.; Haan, Bart J. de; Vos, Paul de

doi:10.1039/d3fo01436c

Cited by 8 publications

(1 citation statement)

References 45 publications

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“… Muñoz-Almagro et al (2021) demonstrated its lipid-lowering effects, reducing cholesterol and triglyceride levels and also highlighted its potential in development of low-glycemic food formulations, which can aid in the prevention and treatment of diabetes. Tang et al (2023) further supported this, showing that LMP can prevent gut epithelial cell barrier disruption and reduce the expression of the sodium-glucose co-transporter, which is involved in glucose transport. They emphasized the stability of LMP in aqueous solutions.…”

Section: Applications Of Pea Pods As Valuable Waste Productsmentioning

confidence: 61%

Bridging sustainability and industry through resourceful utilization of pea pods- A focus on diverse industrial applications

Fatima,

Altemimi

et al. 2024

Food Chemistry: X

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Section: Applications Of Pea Pods As Valuable Waste Productsmentioning

confidence: 61%

Bridging sustainability and industry through resourceful utilization of pea pods- A focus on diverse industrial applications

Fatima,

Altemimi

et al. 2024

Food Chemistry: X

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Gut Epithelial Barrier Function is Impacted by Hyperglycemia and Secondary Bile Acids in Vitro: Possible Rescuing Effects of Specific Pectins

Tang,

Chen,

Ferrari

et al. 2024

Molecular Nutrition Food Res

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Gut epithelial barrier disruption is commonly observed in Western diseases like diabetes and inflammatory bowel disease (IBD). Enhanced epithelial permeability triggers inflammatory responses and gut microbiota dysbiosis. Reduced bacterial diversity in IBD affects gut microbiota metabolism, altering microbial products such as secondary bile acids (BAs), which potentially play a role in gut barrier regulation and immunity. Dietary fibers such as pectin may substitute effects of these BAs.The study examines transepithelial electrical resistance of gut epithelial T84 cells and the gene expression of tight junctions after exposure to (un)sulfated secondary BAs. This is compared to the impact of the dietary fiber pectin with different degrees of methylation (DM) and blockiness (DB), with disruption induced by calcium ionophore A23187 under both normal and hyperglycemic conditions.Unsulfated lithocholic acid (LCA) and deoxycholic acid (DCA) show a stronger rescuing effect, particularly evident under 20 mM glucose levels. DM19 with high DB (HB) and DM43HB pectin exhibit rescuing effects under both glucose conditions. Notably, DM19HB and DM43HB display higher rescue effects under 20 mM glucose compared to 5 mM glucose. The study demonstrates that specific pectins such as DM19HB and DM43HB may serve as alternatives for preventing barrier disruption in the case of disturbed DCA metabolism.

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Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice

Steigerwald,

Blanco-Pérez,

Macías-Camero

et al. 2024

Carbohydrate Polymers

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Efficacy of pectins with different degrees of methyl-esterification and of blockiness in preventing gut epithelial cell barrier disruption and the impact on sodium–glucose co-transporter expression under low and high glucose conditions

Abstract: Pectins support intestinal barrier and have anti-diabetic effects, and can differ in degree of methyl-esterification (DM) and the distribution of non-esterified galacturonic acid residues (DB). Mechanisms and effects of pectin-type...

Cited by 8 publications

References 45 publications

Bridging sustainability and industry through resourceful utilization of pea pods- A focus on diverse industrial applications

Bridging sustainability and industry through resourceful utilization of pea pods- A focus on diverse industrial applications

Gut Epithelial Barrier Function is Impacted by Hyperglycemia and Secondary Bile Acids in Vitro: Possible Rescuing Effects of Specific Pectins

Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice

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