2016
DOI: 10.1016/j.bmc.2016.02.022
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Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis

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Cited by 3 publications
(2 citation statements)
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“…Browne et al 116 reported for the first time, efficacy of PNA and their conjugates for the treatment of amyotrophic lateral sclerosis (ALS) by specific cellular pathologies, as ALS is a neurodegenerative disorder, which affects the spinal cord and nerve cells. Ricciardi et al 117 reported the details of PNA as a site‐specific gene‐editing tool due to its hybridization properties they form a stable triplex complex, which has potential for genome‐specific modification and DNA repair.…”
Section: Applications Of Pnamentioning
confidence: 99%
“…Browne et al 116 reported for the first time, efficacy of PNA and their conjugates for the treatment of amyotrophic lateral sclerosis (ALS) by specific cellular pathologies, as ALS is a neurodegenerative disorder, which affects the spinal cord and nerve cells. Ricciardi et al 117 reported the details of PNA as a site‐specific gene‐editing tool due to its hybridization properties they form a stable triplex complex, which has potential for genome‐specific modification and DNA repair.…”
Section: Applications Of Pnamentioning
confidence: 99%
“…32 Bromination of the same position involved treatment of 3 with bromine, sodium acetate, and acetic acid to yield bromo-menadione (13) in moderate yields (71%). 33 Hydroxylation of 2 was accomplished in two steps. First treatment of 2 with hydrogen peroxide (30%) in sodium carbonate generated 2,3-epoxide-menadione (14), which was subsequently treated with sulfuric acid to yield hydroxy-menadione (15) in an overall yield of 62%.…”
Section: Resultsmentioning
confidence: 99%