Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum: A nonblinded, randomized controlled trial

Grace, Chloe; Larriva, Marti; Steiner, Heidi E.; Marupuru, Srujitha; Campbell, Patrick; Patterson, Hayley Knight; Cropp, Cheryl D.; Quinn, Dorothy; Klimecki, Walter T.; Nix, David E.; Warholak, Terri; Karnes, Jason H.

doi:10.1111/cts.13121

Cited by 10 publications

(3 citation statements)

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“…Therefore, an extensive literature review was conducted regarding the attitudes, perceptions and intentions of health science students regarding PGx and PM. Prior research revealed that students' attitudes towards PGx and PM application and adoption were related, among other factors, to their level of knowledge, their satisfaction from PM and PGx training and their self-confidence to apply PGx and PM in clinical practice [6,7,[13][14][15][21][22][23].…”

Section: Research Framework Of the Proposed Model On Students' Intent...mentioning

confidence: 99%

“…Rahma et al (2021) framework also pinpointed that both pharmacists' knowledge and skills, often assessed by self-confidence, were correlated with their attitudes, and altogether affected their intentions to undergo a PGx training in the future [7]. Grace et al (2021) examined the impact of Personal Genomic educational testing (PGET) on student knowledge, comfort, and attitudes related to PGx in US students, and they noticed a simultaneous improvement in comfort with PGx clinical skills, PGx patient education, and attitudes towards PGx for all participants (receiving or not PGET) over the course of the study [22]. These findings are in line with the results of other studies mentioning that students' PGx knowledge is positively correlated with their self-confidence (readiness) and attitudes towards PGx implementation in clinical practice [13,15].…”

Section: Research Framework Of the Proposed Model On Students' Intent...mentioning

confidence: 99%

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Pharmacy students’ attitudes and intentions of pursuing postgraduate studies and training in pharmacogenomics and personalised medicine

et al. 2023

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Background Pharmacists’ contribution to pharmacogenomics (PGx) implementation in clinical practice is vital, but a great proportion of them are not aware of PGx and its applications. This highlights the university education’s crucial role to prepare pharmacists to face future challenges in such a constantly evolving and demanding environment. Objectives Our study aims to examine pharmacy students’ training satisfaction, knowledge, self-confidence and attitudes towards PGx on their intentions for postgraduate training in PGx and personalised medicine (PM). Methods An initial model on students’ intention to pursue postgraduate training in PGx and PM and its predicting factors, based on the Theory of Planned Behaviour (TPB), was proposed. Based on it, a questionnaire was developed and distributed to 346 pharmacy students of all study years, capturing the selected factors influencing students’ intentions to postgraduate training in PGx and PM, as well as their demographics. Structural equation modelling (SEM) analysis was employed to determine the effects of both the examined factors and demographics on students’ intentions. Results Students did not consider themselves adequately prepared for using PGx in clinical practice. Their attitudes towards PGx implementation were the most important factor influencing their intentions to pursue postgraduate training in PGx and PM. Other factors such as self-confidence and training satisfaction also affected students’ intentions, but to a lower extent. Students of the last two study years (40% of the whole sample) and male (36%) students stated to be less willing to pursue PGx-related studies in the future. Only 10% of the participants claimed to have undergone a recent PGx or genetic test, but this did not affect their intentions. Conclusion There is an important gap in pharmacy school curriculum regarding PGx and PM training which coupled with the slow rate of PGx and PM implementation into clinical practice seems to restrain students’ aspiration to further expand their knowledge and horizons in terms of PGx and PM.

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Section: Research Framework Of the Proposed Model On Students' Intent...mentioning

confidence: 99%

Section: Research Framework Of the Proposed Model On Students' Intent...mentioning

confidence: 99%

Pharmacy students’ attitudes and intentions of pursuing postgraduate studies and training in pharmacogenomics and personalised medicine

et al. 2023

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“…1a). According to recent studies, PGx education is now more regularly incorporated into the curriculum for a majority of healthcare institutions (medical school, nursing school, pharmacy school) across the six continental regions [21,22]. This increase in education is indicative of an increasing acknowledgment of PGx in precision medicine.…”

Section: Healthcare Provider Perspectivementioning

confidence: 99%

Healthcare provider and patient perspectives on the implementation of pharmacogenetic-guided treatment in routine clinical practice

Kaur,

Nwabufo

2024

Pharmacogenetics and Genomics

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Objective This study aims to understand patient and healthcare provider perspectives on the integration and application of pharmacogenetics (PGx) testing in routine clinical practice. Methods Two anonymous online surveys were distributed globally for healthcare providers and patients respectively on the Qualtrics platform (version 3.24). The surveys were distributed through social platforms, email, and posters with QR codes from 27 October 2023 to 7 March 2024. The surveys evaluated participant familiarity with PGx, previous experience with PGx testing, perceived implementation challenges, and opinions on point-of-care (PoC) PGx testing devices. Results This study collected 78 responses from healthcare providers and 98 responses from patients. The results revealed that 64% of healthcare providers had some level of familiarity with PGx, however, PGx testing in clinical practice was low. The primary challenges identified by healthcare providers included limited access to testing and lack of knowledge on PGx test interpretation. In contrast, 52% of patient respondents were aware of PGx testing, with a significant association between awareness and positive opinions toward PGx. Both healthcare providers and patients recognized the value of PoC PGx testing devices, with 98% of healthcare providers and 71% of patients believing PoC devices would improve the accessibility and implementation of PGx testing. Comparative analysis revealed a statistically significant difference in PGx awareness between healthcare providers and patients, with providers being more informed. Conclusion Improved PGx awareness, training, clinical guidelines, and PoC PGx testing devices may help promote the implementation of PGx-guided treatments in routine clinical practice.

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A Scoping Review of Pharmacogenomic Educational Interventions to Improve Knowledge and Confidence

Soueid,

Michael,

Cairns

et al. 2024

American Journal of Pharmaceutical Education

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Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum: A nonblinded, randomized controlled trial

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 10 publications

References 49 publications

Pharmacy students’ attitudes and intentions of pursuing postgraduate studies and training in pharmacogenomics and personalised medicine

Pharmacy students’ attitudes and intentions of pursuing postgraduate studies and training in pharmacogenomics and personalised medicine

Healthcare provider and patient perspectives on the implementation of pharmacogenetic-guided treatment in routine clinical practice

A Scoping Review of Pharmacogenomic Educational Interventions to Improve Knowledge and Confidence

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