Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo

Blanchard, Clara; Denis, Pouchain; Paul, Vanaja; Pérault‐Pochat, Marie‐Christine; Boussageon, Rémy; Vaillant-Roussel, Hélène

doi:10.1007/s00228-018-2416-6

Cited by 26 publications

(17 citation statements)

References 22 publications

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“…Our mutation confirmed that the KR domain affects some polyketide chain-length. In particular, the replacement of Lys 1829 with Asp residue in ChrA KR afforded an remarkably escalated level of 2′,4′,6′-trihydroxyacetophenone ( 14 ), an anti-obesity phytochemical60 that serves as a (bio)synthetic starter motif for arrays of bioactive phloroglucinols 61,62. More interestingly, when ChrA KR and ChrB both lose the catalytic activity, the fungal chromane biosynthetic pathway constructs 13 that tends to form noreugenin ( 8 ), a plant chromone used as a common starting material for the synthesis of bioactive chromone natural products such as ptaeroxylin and eranthin 63.…”

Section: Discussionmentioning

confidence: 99%

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

et al. 2019

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“…Application of phloroglucinol during pregnancy does not increase the risk of fetal malformations [33]. It was applied to relieve renal colic and inhibit uterine contractions for decades [34,35]. Our research showed that application of phloroglucinol after ureteroscopy could reduce the incidence of uterine contractions.…”

Section: Discussionmentioning

confidence: 67%

Risk factors of uterine contraction after ureteroscopy in pregnant women with renal colic

Guo

Luo

et al. 2021

Int Urol Nephrol

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Background Ureteroscopy is widely applied in pregnant women with renal colic, but such patients are easy to experience uterine contraction after surgery. There are many factors which may affect uterine contraction, this study aims to explore the risk factors of uterine contraction triggered by ureteroscopy in pregnant women with renal colic. Methods One hundred and one pregnant women were retrospectively analyzed, the patients were hospitalized because of severe renal colic. All patients received ureteroscopy during which double J catheters were inserted into ureters for drainage. Patients received other medical treatments individually according to their condition and uterine contractions were detected by EHG within 12 h after operation. Patients were classified as group A (uterine contraction) and group B (no uterine contraction) according to the presence or absence of continuously regular uterine contraction. Clinical characteristics were collected for further analysis, including history of childbirth, anesthesia method, application of phloroglucinol or not, operation time, Oxygen inhalation or not, pain relief or not after surgery, systemic inflammatory response syndrome (SIRS) occurred or not. A binary logistic regression analysis model was established to explore whether such clinical characteristics were relevant to uterine contraction after ureteroscopy. Results Continuously regular uterine contraction presented in 46 pregnant women within 12 h after ureteroscopy, making the incidence of uterine contraction as high as 45.54%. The presence of uterine contraction was related to the following factors(P < 0.05): history of childbirth (primipara versus multipara)(OR 6.593, 95% CI 2.231–19.490), operation time (each quarter additional) (OR 2.385, 95% CI 1.342–4.238), application of phloroglucinol (yes versus not) (OR 6.959, 95% CI 1.416–34.194), pain relief after surgery(yes versus not)(OR 6.707, 95% CI 1.978–22.738), SIRS occurred after surgery (yes versus not) (OR 0.099, 95% CI 0.014–0.713). Conclusion Continuously regular uterine contraction is easy to occur within 12 h after ureteroscopy in pregnant women. SIRS occurred after surgery is a risk factor for uterine contraction; on the contrary, no history of childbirth, shorter operation time, application of phloroglucinol, pain relief after surgery are protective factors.

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“…Nevertheless, we did not find antispasmodic effects of phloroglucinol in bladder, while other report described very weak inhibition of phloroglucinol on normal intestinal peristalsis under spasms (Cahen, 1962). More recently, a meta-analysis of clinical reports concluded that only one randomized clinical trial found that phloroglucinol was superior to placebo treating abdominal pain, and that there is insufficient data to justify the wide-spread prescription of phloroglucinol (Blanchard et al, 2018). Moreover, there are medicines with anticholinergic and calcium antagonist properties to synergistically reduce the anormal contractions of bladder due to inestability or hiperactivity of detrusor (Sugaya et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Intestinal, urinary and uterine antispasmodic effects of isoespintanol, metabolite from Oxandra xylopioides leaves

Buñay¹,

Colareda²,

Ragone³

et al. 2018

Phytomedicine

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Consolini , Intestinal, urinary and uterine antispasmodic effects of isoespintanol, metabolite from Oxandra xylopioides leaves, Phytomedicine (2018), ABSTRACTBackground: Isoespintanol is a monoterpene isolated from the leaves of Oxandra xylopioides Diels. (Annonaceae) with antioxidant and antiinflammatory effects. It was of interest to know whether it has antispasmodic effects such as other known drugs, phloroglucinol and trimethoxybenzene, used in therapeutics for treating biliary, urinary and uterine spasms.Purpose: to assess whether isoespintanol possesses antispasmodic effects on intestine, uterus and bladder.Study design: A preclinical study was performed in which isoespintanol, phloroglucinol and trimethoxybenzene were evaluated with concentration-contractile response curves (CRC) of carbachol in isolated rat intestine and bladder, and with CRC of serotonin (5-HT) in rat uterus.Moreover, it was assessed whether isoespintanol interferes with Ca 2+ influx by making CRC of Ca 2+ in high-K + medium in intestine and bladder.Results: isoespintanol non-competitively inhibited the CRC of carbachol with affinity constant (pK) of 4.78 ± 0.09 in intestine and 4.60 ± 0.09 in bladder. Phloroglucinol and trimethoxybenzene were also non-competitive antagonists, but isoespintanol was 8 times more potent than trimethoxybenzene and similarly potent than phloroglucinol in intestine. In bladder, isoespintanol resulted 8 times more potent than trimethoxybenzene. The maximal inhibition of contraction followed the order of isoespintanol > trimethoxybenzene > phloroglucinol in intestine, and isoespintanol > trimethoxybenzene in bladder. Moreover, isoespintanol also completely and non-competitively inhibited the CRC of Ca 2+ , with a pK of 5.1 ± 0.1 in intestine, and 4.32 ± 0.07 in bladder. In uterus isoespintanol reduced, completely and non-competitively, the contraction produced by 5-HT with pK of 5.05 ± 0.07. Conclusions:Results demonstrate that isoespintanol is a very good intestinal, urinary and uterine antispasmodic, with higher potency than the other drugs used in therapeutics. The mechanism of action of isoespintanol is the interference with Ca 2+ influx, at a difference of ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T 3 trimethoxybenzene and phloroglucinol.

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Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo

Abstract: There is insufficient data to justify the wide-spread prescription of phloroglucinol for alleviating abdominal pain.

Cited by 26 publications

References 22 publications

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

Risk factors of uterine contraction after ureteroscopy in pregnant women with renal colic

Intestinal, urinary and uterine antispasmodic effects of isoespintanol, metabolite from Oxandra xylopioides leaves

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