Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review

González-Muñoz, Ana; Cuevas-Cervera, María; Pérez-Montilla, José Javier; Aguilar-Núñez, Daniel; Hamed-Hamed, Dina; Aguilar-García, María; Pruimboom, Leo; Navarro-Ledesma, Santiago

doi:10.3390/healthcare11070938

Cited by 20 publications

(4 citation statements)

References 38 publications

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“…Photobiomodulation (PBM) is a non-invasive therapy that entails the use of red to infrared (IR) light (wavelengths of 600 to 1100 nm) to stimulate cellular processes that promote tissue healing and regeneration [ 1 – 3 ]. Additionally to being studied and used as a therapy for pain relief [ 4 , 5 ], wound healing and skin rejuvenation [ 6 , 7 ], the neuromodulation effects of PBM, when applied to the scalp, have been increasingly more studied, with several clinical studies showing that it could be a safe, non-invasive, and non-destructive alternative to conventional treatments for various neurological disorders.…”

Section: Introductionmentioning

confidence: 99%

Devices used for photobiomodulation of the brain—a comprehensive and systematic review

Fernandes,

Oliveira,

Monteiro

et al. 2024

J NeuroEngineering Rehabil

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A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical and cadaveric approaches, in which light stimuli were applied to the head and/or neck. PubMed, Scopus, Web of Science and Google Scholar databases were used for the systematic search. A total of 2133 records were screened, from which 97 were included in this review. The parameters that were extracted and analysed in each article were the device design, actuation area, actuation site, wavelength, mode of operation, power density, energy density, power output, energy per session and treatment time. To organize device information, 11 categories of devices were defined, according to their characteristics. The most used category of devices was laser handpieces, which relate to 21% of all devices, while 28% of the devices were not described. Studies for cognitive function and physiological characterisation are the most well defined ones and with more tangible results. There is a lack of consistency when reporting PBM studies, with several articles under defining the stimulation protocol, and a wide variety of parameters used for the same health conditions (e.g., Alzheimer’s or Parkinson’s disease) resulting in positive outcomes. Standardization for the report of these studies is warranted, as well as sham-controlled comparative studies to determine which parameters have the greatest effect on PBM treatments for different neurological conditions.

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Section: Introductionmentioning

confidence: 99%

Devices used for photobiomodulation of the brain—a comprehensive and systematic review

Fernandes,

Oliveira,

Monteiro

et al. 2024

J NeuroEngineering Rehabil

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“…Although the mechanism is not fully understood [2][3][4][5]21,22], previous studies using electrophysiological techniques have shown that PBM affects the activity of paintransmitting nerves [23][24][25][26][27][28][29]. These include a few studies in which neural activity was recorded in the spinal dorsal horn, the entry point for pain signals in the central nervous system [30], but these studies do not mention the Rexed laminae of the spinal dorsal horn [28,29].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Laser Intensity at the Peripheral Nerve and Inhibitory Effect of Percutaneous Photobiomodulation on Neuronal Firing in a Rat Spinal Dorsal Horn

Uta

Ishibashi

Kawase

et al. 2023

JCM

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Photobiomodulation is an effective treatment for pain. We previously reported that the direct laser irradiation of the exposed sciatic nerve inhibited firing in the rat spinal dorsal horn evoked by mechanical stimulation, corresponding to the noxious stimulus. However, percutaneous laser irradiation is used in clinical practice, and it is unclear whether it can inhibit the firing of the dorsal horn. In this study, we investigated whether the percutaneous laser irradiation of the sciatic nerve inhibits firing. Electrodes were inserted into the lamina II of the dorsal horn, and mechanical stimulation was applied using von Frey filaments (vFFs) with both pre and post laser irradiation. Our findings show that percutaneous laser irradiation inhibited 26.0 g vFF-evoked firing, which corresponded to the noxious stimulus, but did not inhibit 0.6 g and 8.0 g vFF-evoked firing. The post- (15 min after) and pre-irradiation firing ratios were almost the same as those for direct and percutaneous irradiation. A photodiode sensor implanted in the sciatic nerve showed that the power density reaching the sciatic nerve percutaneously was attenuated to approximately 10% of that on the skin. The relationship between the laser intensity reaching the nerve and its effect could be potentially useful for a more appropriate setting of laser conditions in clinical practice.

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“…Low-power light-emitting diodes (LEDs) and lasers are devices that emitted radiations with clinical applications, such as pain relief, wound healing, treatment of acne and anti-inflammatory activity based on the photobiomodulation (PBM) process [1][2][3][4]. Lasers are able to emit monochromatic, * Author to whom any correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Low-power red laser and blue LED on circadian gene mRNA levels in human breast cancer cells

Ribeiro,

Rodrigues,

dos Santos Soares

et al. 2023

Laser Phys.

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Low-power blue light-emitting diode (LED) and red laser have been used for therapeutic proposals based on photobiomodulation (PBM). This effect is trigged after absorption of radiation by photoacceptors, which lead to molecular, cellular and systemic responses. Cryptochromes are involved in circadian cycle control, and associated with development and progression of tumors. Despite such proteins are able to absorb violet-blue lights, there are few data on their participation in PBM. Thus, this work aims to evaluate the effects of radiations emitted by low-power blue LED (470 nm) and red laser (658 nm) on mRNA levels from cryptochromes genes as well as those from involved in their regulation in human breast cancer cells. The MCF-7 and MDA-MB-231 cells were exposed to low-power blue LED (470 nm, 640 J cm−2) and red laser (660 nm, 9 J cm−2), and relative mRNA levels from CRY1, CRY2, PER2, BMAL1 and CLOCK genes were evaluated by reverse transcription-quantitative polymerase chain reaction. The results suggested that exposure to low-power blue LED and red laser do not alter the mRNA levels from cryptochromes genes, and those involved in their regulation, in MCF-7 and MDA-MB-231 human breast cancer cells.

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Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review

Cited by 20 publications

References 38 publications

Devices used for photobiomodulation of the brain—a comprehensive and systematic review

Devices used for photobiomodulation of the brain—a comprehensive and systematic review

Relationship between Laser Intensity at the Peripheral Nerve and Inhibitory Effect of Percutaneous Photobiomodulation on Neuronal Firing in a Rat Spinal Dorsal Horn

Low-power red laser and blue LED on circadian gene mRNA levels in human breast cancer cells

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