Efficacy of phototherapy in pityriasis lichenoides chronica of dark skin: A retrospective study from a tertiary center in Mexico

Cuéllar-Barboza, Adrián; Garza, Jesús Alberto Cárdenas‐de la; Villarreal-Villarreal, César Daniel; Candiani, Jorge Ocampo; Welsh, Oliverio; Herz‐Ruelas, Maira Elizabeth; Gómez‐Flores, Minerva

doi:10.1111/dth.12734

Cited by 4 publications

(12 citation statements)

References 7 publications

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“…A 50% of complete or partial clearance in each group was found. Cuellar‐Barboza et al . carried out a retrospective study on 19 patients with PL treated with different modalities.…”

Section: Resultsmentioning

confidence: 99%

“…Lesions resolved in three patients after a mean of 4.5 months, with no recurrence after a mean of 7.3 months of follow‐up. Cuellar‐Barboza et al . reported three patients with PLC receiving a combination of oral erythromycin 30–50 mg/kg/day for 3–4 cycles of 7–10 days and class I topical corticosteroids with partial response in all of them.…”

Section: Resultsmentioning

confidence: 99%

“…Two had complete resolution after 2-3 months of treatment and one had partial response after 1 month of treatment. Cuellar-Barboza et al10 reported a retrospective study on 19 patients with PLC treated with different modalities. Eleven patients with PLC were treated with NB UVB with a total cumulative dose ranging between 2.4 and 103.1 J/ cm 2 .…”

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confidence: 99%

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A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. A total of 441 papers were screened, and 37 original manuscripts meeting the inclusion and exclusion criteria were found, including 12 case series, 18 reviews, four prospective studies, two comparative studies and a single randomized controlled study. In most studies, ultraviolet (UV) phototherapy (narrow‐band UVB, broadband UVB, UVA1 or PUVA) was used. Clearance rates with the different modalities are hardly comparable between different studies, ranging approximately between 70% and 100%. Narrow‐band UVB showed an efficacy similar to PUVA as such as the combination of UVA and UVB vs. PUVA. Oral erythromycin showed clearance rates ranging between 66% and 83%, whereas methotrexate up to 100% but in small and dated studies. Evidence for other treatments is scarce. There is a lack of high level of evidence studies on PL treatment. The interpretation of the results is biased by the possible auto‐resolution of the disease, the sample heterogeneity between children and adults and the short follow‐up period of the studies. Only some studies investigated how results were durable after cessation of therapy. Quality of life and the impact of treatment were never assessed. According to the results of this review, we suggest narrow‐band UVB phototherapy as first‐line treatment. Oral erythromycin with or without topical corticosteroids and low‐dose methotrexate as second‐line therapies. High‐powered studies and randomized controlled trials are needed to establish the optimal treatment for PL.

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“…A 50% of complete or partial clearance in each group was found. Cuellar‐Barboza et al . carried out a retrospective study on 19 patients with PL treated with different modalities.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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“…The dose of erythromycin was various among studies, 3‐12 which might influence the treatment response. We compared the response of erythromycin in the low‐dose group and the high‐dose group in 34 patients.…”

Section: Discussionmentioning

confidence: 99%

Oral erythromycin in pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta

Chen

Zhao

Xiang

et al. 2020

Dermatologic Therapy

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Pityriasis lichenoides (PL) is an uncommon cutaneous disorder. Oral erythromycin is proposed to be effective in treating the disease. Here, we reported 16 pediatric patients with PL and systematically reviewed published literatures on erythromycin treatment response in pediatric PL patients, to observe the different treatment response to erythromycin in the pityriasis lichenoides chronica (PLC) and the pityriasis lichenoides et varioliformis acuta (PLEVA) groups. Sixteen patients, 8 with PLC and 8 with PLEVA, were treated with erythromycin. In the PLC group, 25% (n = 2) patients responded to erythromycin, while in the PLEVA group, 87.5% (n = 7) patients responded to erythromycin. The response rate was higher in the PLEVA group than the PLC group (P =.05). No side effect was reported in the 16 patients. A total of 34 children including 16 from our studies were included for further descriptive analysis, in which 12 had PLC and 22 had PLEVA. In the PLC group, 41.7% (n = 5) of patients responded to erythromycin while in the PLEVA group, 90.9 % (n = 20) of patients responded. The response rate was higher in the PLEVA group than the PLC group (P = .004). In conclusion, erythromycin is effective and safe in the treatment of children with PL, and erythromycin was more effective in patients with PLEVA than PLC.

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“…Kang et al, provide some initial insight into a potential role for toll‐like‐receptor signalling in AA . Herz‐Ruelas et al, examine the secretion of stress hormones in AA in response to ultra‐violet A (UVA‐1) phototherapy . These studies suggest that we need to look well beyond the lymphocyte infiltrate and investigate the role of the innate immune system, and the dynamics of hair follicle biology, to fully understand the mechanism(s) of AA pathogenesis as well as the responses to treatment.…”

Section: Alopecia Areatamentioning

confidence: 99%