Efficacy of platelet-rich plasma in posterior lumbar interbody fusion: systematic review and meta-analysis

Pairuchvej, Saran; Muljadi, Janisa Andrea; Arirachakaran, Alisara; Kongtharvonskul, Jatupon

doi:10.1007/s00590-019-02603-3

Cited by 7 publications

(5 citation statements)

References 43 publications

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Section: Application Of Prp In Spine Surgerymentioning

confidence: 98%

“…The study concluded that additional use of PRP did not lead to further significant improvement in patients compared to traditional graft techniques and that PRP may have a limited role in enhancing spinal fusion. However, several other retrospective and metaanalyses have confirmed the role of PRP in promoting new bone formation and bone fusion (102,103). In a prospective randomized controlled trial to evaluate PRP efficacy after posterolateral lumbar fusion surgery, Kubota et al randomly divided 62 patients into PRP and control groups; the final bone union rate, fusion area, and mean union time in the PRP group were significantly better than those of the control group at the end of follow-up period (104).…”

Section: Treatment Of Spinal Fusionmentioning

confidence: 99%

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Application of platelet-rich plasma in spinal surgery

et al. 2023

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With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these treatment methods have several drawbacks such as drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is more challenging to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.

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Section: Application Of Prp In Spine Surgerymentioning

confidence: 98%

Section: Treatment Of Spinal Fusionmentioning

confidence: 99%

Application of platelet-rich plasma in spinal surgery

et al. 2023

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“…Nevertheless, at a clinical setting, PRP and autograft bone chip induced higher fusion rates than those of the latter alone 124) . Recently, a metaanalysis suggested that fusion rate is unaffected by the addition of PRP, yet improvement of back pain and faster bone union can be achieved 125) . These results are challenged by another meta-analysis that found no difference in quality of life but lower chance of successful fusion with PRP 126) .…”

Section: Prp and Spinementioning

confidence: 99%

Platelet-Rich Plasma for Degenerative Spine Disease: A Brief Overview

Apostolakis

Kapetanakis

2024

Spine Surg Relat Res

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BackgroundThe emergence of novel minimally invasive techniques has opened new horizons for the management of degenerative diseases of the spine. Plateletrich plasma (PRP) has gained considerable attention through its applications in various pathologies. In the present review, an overview of the science behind the application of PRP is provided, ultimately focusing on the clinical trials that may render it a useful tool in the hands of spine surgeons in the future. MethodsA review of the available literature is conducted, focusing on its existing clinical and experimental applications with a particular interest in the degenerative diseases of the spine. ResultsIn terms of the degenerative diseases of the spine, initial studies suggest that it is a safe and effective method that could change the practice of spinal cord medicine in the years to come. The available studies demonstrate that besides being minimally invasive, causing less discomfort than that of surgery, it

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“…Platelet-rich plasma (PRP) is blood plasma containing concentrated autologous platelets containing several growth factors such as platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), and insulin-like growth factor (IGF) [5][6][7]. Therefore, PRP is used to accelerate bone and soft tissue healing not only in oral dentistry, dermatology, ophthalmology, and sports medicine, but also in spinal fusion surgery [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of platelet-rich plasma impregnation for unidirectional porous β-tricalcium phosphate in lateral lumbar interbody fusion: study protocol for a prospective controlled trial

Sato

Funayama

Noguchi

et al. 2022

Trials

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Background The use of platelet-rich plasma has been increasing in spinal fusion surgery. However, the efficacy of platelet-rich plasma in lateral lumbar interbody fusion is unclear. In Japan, Affinos,® (Kuraray Co., Tokyo, Japan), a β-tricalcium phosphate artificial bone, has been increasingly used for spinal fusion. The purpose of this trial is to demonstrate whether Affinos® impregnated with platelet-rich plasma can achieve a higher fusion rate and better clinical outcomes than Affinos® alone. Methods The current study is a prospective randomized controlled trial. This trial will include consecutive patients scheduled for lateral lumbar interbody fusion. An intervertebral cage for lateral lumbar interbody fusion has two spaces for bone grafts. As a consequence, two bone grafts are inserted at each intervertebral level. In this study, an artificial bone with platelet-rich plasma will be inserted into one space, and an artificial bone without platelet-rich plasma will be inserted into the other space. We will compare the fusion rates between the bone grafts with and without platelet-rich plasma. Our primary endpoint will be the interbody fusion rate at 1 year after surgery. Discussion This trial will verify the efficacy of platelet-rich plasma with Affinos® for bony fusion in lateral lumbar interbody fusion. It will also provide substantial evidence for the effectiveness and safety of platelet-rich plasma in spinal fusion surgery. Trial registration Japan Registry of Clinical Trials (jRCT) jRCTb032200199. First registered on 13 November 2020. jRCT is approved as a member of the Primary Registry Network of WHO ICTRP.

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Efficacy of platelet-rich plasma in posterior lumbar interbody fusion: systematic review and meta-analysis

Cited by 7 publications

References 43 publications

Application of platelet-rich plasma in spinal surgery

Application of platelet-rich plasma in spinal surgery

Platelet-Rich Plasma for Degenerative Spine Disease: A Brief Overview

Efficacy of platelet-rich plasma impregnation for unidirectional porous β-tricalcium phosphate in lateral lumbar interbody fusion: study protocol for a prospective controlled trial

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