Efficacy of platelet-rich plasma injection in mild and moderate carpal tunnel syndrome: randomized control study

Abstract

Background: Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy. Typical symptoms and signs include numbness, tingling, pain, or burning sensation in the digits supplied by the median nerve and/or nocturnal paresthesia. Treatments of CTS range from conservative measures to surgical decompression of the median nerve. Results: The PRP group showed a statistically significant reduction in the visual analog scale, Boston Carpal Tunnel Syndrome Questionnaire, for the severity and the functional capacity scores, and cross-sectional area of the median nerve compared to those of control group 3 months post-treatment (p < 0.05). Conclusions: Platelet-rich plasma injection in CTS relieves pain and symptom severity and improves functional status but not significantly improve the electrophysiological parameters.

Local injection therapy for carpal tunnel syndrome: a network meta-analysis of randomized controlled trial

“…3. The follow-up time was only 10 weeks (Raeissadat et al, 2018), which is less than that in other studies, and a delayed effect of PRP was reported in the relevant literature (Wu et al, 2017a;Gado and El-Banna, 2020).…”

“…And in a related study, which confirms our speculation, compared to the study of Raeissadat et al, Gado et al used ultrasound-guided injection using an in-plane ulnar approach; the puncture needle was passed from the ulnar side of the wrist joint to the MN, and 2 mL of PRP was injected, and the flexor supporting band of nerves was stripped with water, and the remaining 1 mL of PRP was injected underneath the MN, and evaluated the results of the treatment in 40 patients (PRP + S group 20 patients and splint group 20 patients) at 3-month follow-up, and their results showed that the differences in VAS, SSS, FSS and CSA between the two groups at 1 month after treatment were not statistically significant; however, patients in the PRP combined with brace group showed better improvement in all of the above indexes than those in the brace-only group at 3 months after treatment ( Gado and El-Banna, 2020 ), indicating that there is a delayed effect of PRP and that PRP injection dose of 3 mL is better than 1 mL.…”