Efficacy of polyethylene glycol 3350 as compared to lactulose in treatment of ROME IV criteria–defined pediatric functional constipation: A randomized controlled trial

Dheivamani, Nirmala; Thomas, Winston; Bannerjii, Rohit; Mukherjee, M. K.; Mitra, Monjori

doi:10.1007/s12664-021-01148-w

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…In 2016, a Cochrane meta-analysis included studies that compared PEG with placebo, showing a higher frequency of stools per week in children treated with PEG [ 26 ]. Several RCTs have compared the efficacy of PEG and lactulose and the same Cochrane meta-analysis reported a significantly higher defecation frequency for PEG [ 26 , 32 , 33 ]. However, these results should be interpreted with caution because of the low quality of the included studies.…”

Section: Osmotic Laxativesmentioning

confidence: 99%

“…As previously mentioned, evidence has shown that PEG is more effective for the treatment of FC in children than lactulose; however, the difference in defecation frequency is minor (mean difference of 0.7) [ 26 , 32 , 33 ]. The same Cochrane review also compared the efficacy of lactulose with mineral oil (liquid paraffin) and magnesium hydroxide (milk of magnesia), and showed a statistically significant difference in defecation frequency favoring mineral oil and magnesium hydroxide.…”

Section: Osmotic Laxativesmentioning

confidence: 99%

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An Update of Pharmacological Management in Children with Functional Constipation

et al. 2023

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Functional constipation is a common problem in childhood worldwide and has a great impact on social, physical, and emotional functioning of affected children and their caregivers. It is a clinical diagnosis based on the Rome IV criteria. Nonpharmacological treatment involves education, demystification, lifestyle advice, and toilet training. Pharmacological treatment consists of disimpaction, maintenance treatment, and eventually weaning if possible. Polyethylene glycol is considered as the first choice of laxative for both disimpaction and maintenance treatment. Different osmotic laxatives, stimulant laxatives, lubricants, and enemas are available as alternative pharmacological treatment options. Novel drugs are emerging but evidence to support the widespread application of these drugs in the pediatric population is often lacking and more high-quality research is needed in this field. If children remain symptomatic despite optimal pharmacological treatment, botulinum toxin injections in the anal sphincter can be considered as an alternative, more invasive treatment option. This review provides an update on currently available literature concerning the pharmacologic treatment of functional constipation in children.

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Section: Osmotic Laxativesmentioning

confidence: 99%

Section: Osmotic Laxativesmentioning

confidence: 99%

An Update of Pharmacological Management in Children with Functional Constipation

et al. 2023

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“…Currently, PEG is the first choice for treating constipation-associated FI in children ( 52 ). Dheivamani proved that PEG 3,350 was superior to lactulose in the maintenance therapy of young children with functional constipation ( 53 ). Polyethylene glycol has been routinely recommended in the treatment of constipation-related FI in NASPGHAN/ESPGHAN guidelines.…”

Section: Management Of Fi In Children and Adolescentsmentioning

confidence: 99%

Diagnosis and management of fecal incontinence in children and adolescents

Shen

Zhang²,

Bai

et al. 2022

Front. Pediatr.

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Fecal incontinence (FI) is a commonly occurring disease of high concern. It is characterized by voluntary and involuntary defecation in children and adolescents. It is not only a physical disease but also a psychological and behavioral disorder. FI poses a serious burden on individuals and their families and therefore has become a social problem. Unfortunately, the management of FI among children is still a challenge because the etiology varies widely. Constipation has been found to be the most common cause, while sphincter dysfunction and neurogenic abnormalities may also play a role. Currently, no consensus guidelines exist, and the criteria for selecting optional methods remain unclear. It is therefore necessary to improve the efficacy of diagnosis and management strategies of FI in children. This review focused on the classification and etiology, discussed the diagnosis and management methods of FI in children and adolescents, and aimed to guide future studies.

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“…International societal guidelines advocate a combination of dietary, lifestyle and pharmacological measures with laxatives to treat this condition [22,23]. Dheivamani et al from the Institute of Child Health, Chennai and Kolkata, India report a randomized trial on 100 children with functional constipation comparing the efficacy of polyethylene glycol (PEG) 3350 and lactulose in the treatment of functional constipation [24]. A significant increase in stool frequency was noted in the (PEG) 3350 group by week 1, a trend maintained through week 4.…”

Section: Efficacy Of Polyethylene Glycol 3350 As Compared To Lactulose In Treatment Of Rome IV Criteria Defined Pediatric Functional Consmentioning

confidence: 99%

Editorial commentary on the Indian Journal of Gastroenterology - March-April 2021

Limdi

2021

Indian J Gastroenterol

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Respiratory function and comfort levels in three different defecatory simulation postures in the elderlyConstipation is common in the elderly and maintaining a sitting position for long durations during defecation increases fatigue. The availability of handrails that enable the arm-supported, forward-leaning position has shown positive effects, on respiratory function reducing dyspnea and decreasing the work of breathing [1]. Tashiro and colleagues from the

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Efficacy of polyethylene glycol 3350 as compared to lactulose in treatment of ROME IV criteria–defined pediatric functional constipation: A randomized controlled trial

Cited by 10 publications

References 20 publications

An Update of Pharmacological Management in Children with Functional Constipation

An Update of Pharmacological Management in Children with Functional Constipation

Diagnosis and management of fecal incontinence in children and adolescents

Editorial commentary on the Indian Journal of Gastroenterology - March-April 2021

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