Efficacy of Ponseti Technique in Virgin and Relapsed Clubfeet: A Comparative Study

Khan, Prince Shanavas; John, Bobby; Bhatty, Shiraz

doi:10.1053/j.jfas.2018.05.004

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Socioeconomic factors and familial and treatment compliance have illustrated their effects in causing relapses in some patients. 2,[9][10][11] Unfortunately, the role of genes, which had been in question for a while, has shown to be understudied, as seen by the insufficient number of studies. Genetic causes have been linked to the occurrence of idiopathic clubfoot after studies showed linkage through positive family history, twin studies, higher incidence in certain areas and gender.…”

Section: Discussionmentioning

confidence: 99%

Genetic Role in Recurrence of Idiopathic CTEV: A Systematic Review

Muhammad¹,

Haryana²,

Magetsari³

et al. 2023

ORR

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Background: Congenital Talipes Equinovarus (CTEV) is a multitude of deformities involving equinus, varus, adductus, and cavus deformities. Clubfoot affects 1 in every 1000 infants born worldwide, with various incidences according to geographical areas. It has been previously hypothesized that the possible genetic role in Idiopathic CTEV (ICTEV) might have a treatment-resistant phenotype. However, the genetic involvement in recurrent ICTEV cases is yet to be determined. Aim: To systematically review existing literature regarding the discovery of genetic involvement in recurrent ICTEV to date to further understand the etiology of relapse. Methods: A comprehensive search was performed on medical databases, and the review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A comprehensive search was performed on several medical databases: PubMed (MEDLINE), Scopus, the Cochrane Library, and European PMC on May 10, 2022. We included studies reporting patients with recurring idiopathic CTEV or CTEV of unknown cause after treatment, reporting whole-genetic sequencing, whole-exome sequencing, Polymerase Chain Reaction, or Western blot analysis as methods of genetic analysis (intervention) and providing results of idiopathic CTEV genetic involvement. Non-English studies, literature reviews, and irrelevant articles were excluded. Quality and risk of bias assessments were performed using Newcastle-Ottawa Quality Assessment Scale for nonrandomized studies where appropriate. The authors discussed data extracted with the primary outcome of gene(s) frequency being reported of their involvement in recurrent ICTEV cases. Results: Three pieces of literature were included in this review. Two studies analyzed the genetic involvement in CTEV occurrence, while one analyzed the protein types found. Discussion: With included studies of less than five, we could not perform other forms of analysis apart from qualitatively. Conclusion:The rarity of literature exploring the genetic etiology of recurrent ICTEV cases has been reflected in this systematic review, giving opportunities for future research.

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Section: Discussionmentioning

confidence: 99%

Genetic Role in Recurrence of Idiopathic CTEV: A Systematic Review

Muhammad¹,

Haryana²,

Magetsari³

et al. 2023

ORR

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“…This study established that the Ponseti method is a gold standard in clubfoot treatment. Further studies said that the Ponseti method has a success rate of 75% to 90% 42,43 or even higher 44,45 and is equally effective in treating relapsed cases 46 . Of the 193 United Nations member countries, 113 have adopted the Ponseti method 8 as the standard method of clubfoot treatment.…”

Section: Clubfoot Treatment Methodsmentioning

confidence: 99%

Clubfoot: Review on Assessment, Treatment, Challenges, and Engineering Aspects

Singh¹,

Mali²

2022

J Prosthet Orthot

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IntroductionClubfoot, mainly CTEV, is a complex three-dimensional deformity challenging physicians from ancient times. Among a thousand babies born, one to six suffer from clubfoot deformity; that is, in India alone, around 35,000 need treatment for clubfoot annually. This review summarizes the various practices of clubfoot assessment, noninvasive treatment, and engineering aspects of clubfoot treatment. The shortcomings of assessment methods and challenges with implementation of treatment methods are also presented.MethodsA narrative review of all related research papers available to authors was carried out.ResultsVarious clubfoot assessment methods have been developed to help physicians understand the severity of the problem and predict treatment parameters. The Pirani score and Dimeglio score are used predominantly for the assessment of deformity. However, these methods suffer from implementation-related limitations. Noninvasive methods, namely, Kite's method, functional physiotherapy method, and Ponseti method, are used in practice for treatment. The Ponseti method is the most popular with parents and physicians and is considered the gold standard for the treatment of clubfoot. However, it also suffers from various implementation issues, like treatment cost and lack of experts, particularly in low- and middle-income countries (LMICs). Engineers are using various technologies like computer-aided design (CAD)/computer-aided engineering (CAE) and additive manufacturing for modeling and analysis of clubfoot. Engineers have also attempted to develop corrective and maintenance orthosis for CTEV treatment.ConclusionsBecause newer and newer technologies are becoming accessible for interdisciplinary use, there is a need to apply contemporary technologies, especially to develop a corrective orthosis so that the current challenges of clubfoot assessment and treatment are addressed. The corrective orthosis should be based on Dr Ponseti's insights into clubfoot biomechanics.Clinical RelevanceThere is a need to explore contemporary technologies like data acquisition and CAD/CAE to address CTEV assessment–related issues. A corrective orthosis based on the understanding of the foot biomechanics for treatment can solve the various implementation-related challenges of the Ponseti method, particularly in low-resource settings.

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Foot abduction orthosis compliance in clubfoot treatment

Singh

Mali

2023

3D Printing in Podiatric Medicine

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Efficacy of Ponseti Technique in Virgin and Relapsed Clubfeet: A Comparative Study

Cited by 7 publications

References 26 publications

Genetic Role in Recurrence of Idiopathic CTEV: A Systematic Review

Genetic Role in Recurrence of Idiopathic CTEV: A Systematic Review

Clubfoot: Review on Assessment, Treatment, Challenges, and Engineering Aspects

Foot abduction orthosis compliance in clubfoot treatment

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