“…Over the course of human history, placental tissue has been consumed or placental extract (PE) has been administered orally, topically, or through injection for nutritional, pharmaceutical, and cosmetic purposes. For nearly a half‐century, industrialized manufacturing of PE has provided numerous benefits, or so it appears, to individuals suffering from such symptoms as skin aging, nonhealing wounds, contact hypersensitivity, impaired liver function, steatohepatitis, and menopausal disorder . Although the effectiveness of PE in some of these applications/indications may simply result from supplementation of nonspecific components such as small peptides, nutritional amino acids, vitamins, and minerals, some may also result from specific biological signaling.…”