Efficacy of Postoperative FOLFOX Versus XELOX Chemotherapy for Gastric Cancer and Prognostic Value of Platelet–Lymphocyte Ratio in Patients Receiving XELOX

Yin, Xin; Fang, Tianyi; Wang, Yimin; Li, Chunfeng; Wang, Yufei; Zhang, Daoxu; Xue, Yingwei

doi:10.3389/fonc.2020.584772

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…Yin et al found that the dynamic changes in the PLR could evaluate the sensitivity of GC patients to XELOX chemotherapy. 41 Therefore, our follow-up studies may predict the Malnutrition is related to the highly aggressiveness of tumors. 42 Due to the high incidence of clinical symptoms such as reflux and malignant obstruction, and radical gastrectomy removes at least two-thirds of the stomach and omentum and D2 or D2+ lymph node dissection, these factors may directly increase the nutritional burden of GC patients, these mechanisms may explain that the cutoff value of TC for GC is lower than that for CRC (156.81 vs. 180).…”

Section: Discussionmentioning

confidence: 99%

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Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer

et al. 2022

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Background The wide applicability of the Naples prognostic score (NPS) is still worthy of further study in gastric cancer (GC). This study aimed to construct a New‐NPS based on the differences in immunity and nutrition in patients with upper and lower gastrointestinal tumors to help obtain an individualized prediction of prognosis. Methods This study retrospectively analyzed patients who underwent radical gastrectomy from April 2014 to September 2016. The cutoff values of the preoperative neutrophil‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte ratio (LMR), serum albumin (Alb), and total cholesterol (TC) were calculated by ROC curve analysis. ROC and t‐ROC were used to evaluate the accuracy of the prognostic markers. The Kaplan–Meier method and log‐rank test were used to analyze the overall survival probability. Univariate and multivariate analyses based on Cox risk regression were used to show the independent predictors. The nomogram was made by R studio. The predictive accuracy of nomogram was assessed using a calibration plot, concordance index (C‐index), and decision curve. Results A total of 737 patients were included in training cohort, 411 patients were included in validation cohort. ROC showed that the New‐NPS was more suitable for predicting the prognosis of GC patients. NPS = 2 indicated a poor prognosis. Multivariate analysis showed that CEA (P = 0.026), Borrmann type (P = 0.001), pTNM (P < 0.001), New‐NPS (P < 0.001), and nerve infiltration (P = 0.035) were independent risk factors for prognosis. Conclusion The New‐NPS based on the cutoff values of NLR, LMR, Alb, and TC is not only suitable for predicting prognosis but can also be combined with clinicopathological characteristics to construct a nomogram model for GC patients.

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Section: Discussionmentioning

confidence: 99%

“…Yin et al found that the dynamic changes in the PLR could evaluate the sensitivity of GC patients to XELOX chemotherapy. 41 Therefore, our follow‐up studies may predict the prognosis of patients based on the dynamic changes in the NPS before and after surgery.…”

Section: Discussionmentioning

confidence: 99%

Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer

et al. 2022

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“…Cancer cells produce granulocyte colony-stimulating factor (G-CSF), which promotes the upregulation of circulating neutrophils ( 20 ). Elevated neutrophils can secrete interleukin (IL)-1, IL-10, and vascular endothelial growth factor (VEGF), thereby inhibiting lymphocytes and natural killer cells, stimulating angiogenesis and promoting tumor progression ( 21 ). Lymphocyte reduction may depress lymphocyte-mediated antitumor cellular immune responses ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Preoperative peripheral blood inflammatory markers especially the fibrinogen-to-lymphocyte ratio and novel FLR-N score predict the prognosis of patients with early-stage resectable extrahepatic cholangiocarcinoma

Zhang

Lou

et al. 2022

Front. Oncol.

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BackgroundSystemic inflammation is important in the development of extrahepatic cholangiocarcinoma (ECC). The aim of this study was to compare the prognostic power of preoperative peripheral blood inflammatory markers and the novel FLR-N score in patients with resectable ECC.MethodsA total of 140 patients with resectable ECC and 140 healthy controls (HCs) were recruited for the study. The Mann−Whitney U test was used to evaluate the differences in inflammatory markers between groups. Kaplan−Meier and Cox regression analyses were used to evaluate the prognostic power of preoperative fibrinogen, albumin, prealbumin, bilirubin, neutrophils, lymphocytes, monocytes, platelets, fibrinogen-to-lymphocyte ratio (FLR), fibrinogen-to-albumin ratio (FAR), fibrinogen-to-prealbumin ratio (FPR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), FLR-neutrophil (FLR-N) score, and CA19-9 in patients with resectable ECC. Nomogram was developed based on the results of multivariate Cox analyses.ResultsPatients with resectable ECC had significantly higher levels of neutrophils, monocytes, fibrinogen, FLR, FAR, FPR, NLR, PLR, and MLR and lower levels of lymphocytes, albumin, and prealbumin than HCs (all P < 0.01). Albumin, prealbumin, and FPR had a good ability to distinguish between ECC patients with total bilirubin < 34 µmol/L and HCs (AUCs of 0.820, 0.827, and 0.836, respectively). Kaplan−Meier analysis showed that high neutrophil, fibrinogen, FLR, FAR, PLR, MLR, and FLR-N score values were associated with poor survival in patients with resectable ECC. Multivariate analyses indicated that neutrophils (P = 0.022), FLR (P = 0.040), FLR-N score (P < 0.0001), and positive lymph node metastasis (P = 0.016) were independent factors for overall survival (OS). Nomogram were developed to predict OS for patients with ECC.ConclusionThe prognostic roles of inflammatory markers in patients with resectable ECC were different. The preoperative neutrophil count, FLR and FLR-N score could serve as noninvasive markers for predicting the prognosis of resectable ECC.

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“…however, their clinical use was limited by complex detection techniques and lack of confirmation from big data. Inflammation plays an important role in the occurrence, invasion and migration, distant metastasis and chemotherapy resistance of gastric cancer (19)(20)(21). However, it remains unclear whether the levels of inflammatory markers in peripheral blood are associated with lymph node metastasis in early gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Construction of a nomogram for preoperative prediction of the risk of lymph node metastasis in early gastric cancer

et al. 2023

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BackgroundThe status of lymph node metastasis (LNM) in patients with early gastric cancer (EGC) is particularly important for the formulation of clinical treatment. The purpose of this study was to construct a nomogram to predict the risk of LNM in EGC before operation.MethodsUnivariate analysis and logistic regression analysis were used to determine the independent risk factors for LNM. The independent risk factors were included in the nomogram, and the prediction accuracy, discriminant ability and clinical practicability of the nomogram were evaluated by the receiver operating characteristic curve (ROC), calibration curve and clinical decision curve (DCA), and 100 times ten-fold cross-validation was used for internal validation.Results33 (11.3%) cases of AGC were pathologically confirmed as LNM. In multivariate analysis, T stage, presence of enlarged lymph nodes on CT examination, carbohydrate antigen 199 (CA199), undifferentiated histological type and systemic inflammatory response index (SIRI) were risk factors for LNM. The area under the ROC curve of the nomogram was 0.86, the average area under the ROC curve of the 100-fold ten-fold cross-validation was 0.85, and the P value of the Hosmer-Lemeshow test was 0.60. In addition, the clinical decision curve, net reclassification index (NRI) and Integrated Discriminant Improvement Index (IDI) showed that the nomogram had good clinical utility.ConclusionsWe found that SIRI is a novel biomarker for preoperative prediction of LNM in EGC, and constructed a nomogram for preoperative prediction of the risk of LNM in EGC, which is helpful for the formulation of the clinical treatment strategies.

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Efficacy of Postoperative FOLFOX Versus XELOX Chemotherapy for Gastric Cancer and Prognostic Value of Platelet–Lymphocyte Ratio in Patients Receiving XELOX

Cited by 8 publications

References 49 publications

Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer

Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer

Preoperative peripheral blood inflammatory markers especially the fibrinogen-to-lymphocyte ratio and novel FLR-N score predict the prognosis of patients with early-stage resectable extrahepatic cholangiocarcinoma

Construction of a nomogram for preoperative prediction of the risk of lymph node metastasis in early gastric cancer

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