Efficacy of Praziquantel Loaded Chitosan Nanoparticles Against Both Adult and Schistosomula Stages of Schistosoma Mansoni

Sadek, Gehan S; Harba, Nancy M.; El-Refai, Samar A.; El-Deen, Shaimaa Ahmed Sharaf; Saleh, Mona

doi:10.21608/jesp.2018.76578

Cited by 7 publications

(2 citation statements)

References 41 publications

(42 reference statements)

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“…Additionally, the surface topography displayed that the male worms obtained from Sidr honey-treated mice possessed comprehensive loss of spines [57]. Supporting our results, Sadek et al reported that Cs Nps treatment either alone or loaded with PZQ led to adult changes in the form of edema and whole tegument swelling [60].…”

Section: Discussionsupporting

confidence: 84%

In Vivo Evaluation of the Anti-Schistosomal Potential of Ginger-Loaded Chitosan Nanoparticles on Schistosoma mansoni: Histopathological, Ultrastructural, and Immunological Changes

El-Derbawy

Salem

Raboo

et al. 2022

Life

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Chemotherapy is the most widely advocated method of Schistosome control. However, repeated chemotherapy leads to the emergence of drug-resistant Schistosoma strains. Therefore, efforts to find alternative drugs, especially those of natural origin, have risen globally. Nanoparticles (NPs) have received special interest as efficient drug delivery systems. This work aimed to investigate the anti-schistosomal potential of Zingiber officinale (ginger, Zingiberaceae)-loaded chitosan nanoparticles (GCsNPs) on Schistosoma mansoni experimentally infected mice that were exposed to 80 ± 10 cercariae/mouse. The study groups are: (G1) negative control; (G2) positive control; (G3) praziquantel in a dose of 500 mg/kg/day for two consecutive days; (G4) ginger in a dose of 500 mg/kg treated; (G5) chitosan nanoparticles in a dose 3 mg/kg (G6) GCsNPs in a dose 250 mg/kg; and (G7) GCsNPs in a dose 500 mg/kg. The anti-schistosome potential was assessed using histopathological scanning electron microscopically and immunological parameters. The results showed that there was a significant decrease in cellular granuloma count (p < 0.05) and granuloma diameter (p < 0.001) in all infected treated mice groups, in comparison to the infected non-treated group with the highest reduction in both G3 and G7. SEM of S. mansoni adult worm recovered from G3 showed mild edema of oral and ventral suckers with some peeling and blebs around them, while that recovered from G7 showed abnormal oedematous oral and retracted ventral sucker, edema of the tegument, rupture of many tubercles with vacuolation and complete loss of spines. All infected treated mice groups, in comparison to positive control G2, showed a significant reduction in IL-4, IL-10, and TNF-α levels (p-value < 0.001), especially groups G6 and G7 (p-value < 0.05); both G6 and G7 values were nearer to the normal that indicated recovery of the liver tissue.

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Section: Discussionsupporting

confidence: 84%

In Vivo Evaluation of the Anti-Schistosomal Potential of Ginger-Loaded Chitosan Nanoparticles on Schistosoma mansoni: Histopathological, Ultrastructural, and Immunological Changes

El-Derbawy

Salem

Raboo

et al. 2022

Life

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“…The nanoformulation reduces the worm load in mice by 60% (predominantly female) and the number of couples found in vivo. Although the results showed a clear difference between control groups and the groups treated with nanoparticles, the author considered the results not good enough since other works showed a more prominent reduction [ 62 ]. Regarding egg counts in the liver and intestine, the nanoformulation was more efficient than blank particles which shows the relevance of nanoparticle for drug delivery.…”

Section: Resultsmentioning

confidence: 92%

Nanotechnological approaches in the treatment of schistosomiasis: an overview

Carvalho,

Sarcinelli,

Patrício

2024

Beilstein J. Nanotechnol.

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Schistosomiasis causes over 200,000 deaths annually. The current treatment option, praziquantel, presents limitations, including low bioavailability and resistance. In this context, nanoparticles have emerged as a promising option for improving schistosomiasis treatment. Several narrative reviews have been published on this topic. Unfortunately, the lack of clear methodologies presented in these reviews leads to the exclusion of many important studies without apparent justification. This integrative review aims to examine works published in this area with a precise and reproducible method. To achieve this, three databases (i.e., Pubmed, Web of Science, and Scopus) were searched from March 31, 2022, to March 31, 2023. The search results included only original research articles that used nanoparticles smaller than 1 µm in the treatment context. Additionally, a search was conducted in the references of the identified articles to retrieve works that could not be found solely using the original search formula. As a result, 65 articles that met the established criteria were identified. Inorganic and polymeric nanoparticles were the most prevalent nanosystems used. Gold was the primary material used to produce inorganic nanoparticles, while poly(lactic-co-glycolic acid) and chitosan were commonly used to produce polymeric nanoparticles. None of these identified works presented results in the clinical phase. Finally, based on our findings, the outlook appears favorable, as there is a significant diversity of new substances with schistosomicidal potential. However, financial efforts are required to advance these nanoformulations.

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Dandelion (Taraxacum officinale) Improves the Therapeutic Efficiency of Praziquantel in Experimental Schistosomiasis

2022

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Efficacy of Praziquantel Loaded Chitosan Nanoparticles Against Both Adult and Schistosomula Stages of Schistosoma Mansoni

Cited by 7 publications

References 41 publications

In Vivo Evaluation of the Anti-Schistosomal Potential of Ginger-Loaded Chitosan Nanoparticles on Schistosoma mansoni: Histopathological, Ultrastructural, and Immunological Changes

In Vivo Evaluation of the Anti-Schistosomal Potential of Ginger-Loaded Chitosan Nanoparticles on Schistosoma mansoni: Histopathological, Ultrastructural, and Immunological Changes

Nanotechnological approaches in the treatment of schistosomiasis: an overview

Dandelion (Taraxacum officinale) Improves the Therapeutic Efficiency of Praziquantel in Experimental Schistosomiasis

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