Efficacy of Prednisolone in Recovery from Acute Bronchiolitis: Study in a Tertiary Care Hospital, Dhaka, Bangladesh

Acute bronchiolitis is a common and deadly condition in infants described as a respiratory infection due to inflammatory obstruction of bronchioles. This study was designed to assess prednisolone's efficacy in treating bronchiolitis in children aged >2 years. A retrospective study was conducted in the Department of peadiatrics in different hospitals from February 2022- February 2023. A total of 80 children aged > 2 years with acute bronchiolitis were included in the study. The patients were divided into groups A and B. Group A (n=40) was administered salbutamol combined with prednisolone, and Group B (n=40) was administered salbutamol alone. The outcomes of both treatments were evaluated. The average age in group A and B was 6.9± 4.5 months and 5.5 ± 3.9 months, respectively. 65 patients (81.2%) belonged to middle-class families, and 20 (25%) came from crowded households. 10 patients (12.5%) had a preterm delivery, and 12 (15%) had low birth weight. A significant difference was observed in Group A after 3 days of treatment (p <0.05), and a reduction in hospital stay was also noted (p<0.001) in contrast with Group B. Based on the results, it can be concluded that the prednisolone is an effective drug in the management of bronchiolitis by reducing hospital stay and disease severity in children > 2 years.

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“…48.84/ mint) (p<0.001). Other studies have drawn similar conclusions (Gelbart et al, 2022;Hasan et al, 2021).…”

Section: Discussionsupporting

confidence: 66%

Efficacy of Oral Prednisolone in Management of Bronchiolitis: A Placebo-Controlled Study

TAJ¹,

BATOOL

KHIZER

2023

Biol Clin Sci Res J

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Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review

Ambrożej

Makrinioti²,

Whitehouse³

et al. 2022

Front. Immunol.

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It has become clear that severe bronchiolitis is a heterogeneous disease; even so, current bronchiolitis management guidelines rely on the one-size-fits-all approach regarding achieving both short-term and chronic outcomes. It has been speculated that the use of molecular markers could guide more effective pharmacological management and achieve the prevention of chronic respiratory sequelae. Existing data suggest that asthma-like treatment (systemic corticosteroids and beta2-agonists) in infants with rhinovirus-induced bronchiolitis is associated with improved short-term and chronic outcomes, but robust data is still lacking. We performed a systematic search of PubMed, Embase, Web of Science, and the Cochrane’s Library to identify eligible randomized controlled trials to determine the efficacy of a personalized, virus-dependent application of systemic corticosteroids in children with severe bronchiolitis. Twelve studies with heterogeneous methodology were included. The analysis of the available results comparing the respiratory syncytial virus (RSV)-positive and RSV-negative children did not reveal significant differences in the associatons between systemic corticosteroid use in acute episode and duration of hospitalization (short-term outcome). However, this systematic review identified a trend of the positive association between the use of systematic corticosteroids and duration of hospitalization in RSV-negative infants hospitalized with the first episode of bronchiolitis (two studies). This evidence is not conclusive. Taken together, we suggest the design for future studies to assess the respiratory virus type in guiding predictive enrichment approaches in infants presenting with the first episode of bronchiolitis.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42020173686

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Efficacy of Prednisolone in Recovery from Acute Bronchiolitis: Study in a Tertiary Care Hospital, Dhaka, Bangladesh

Cited by 2 publications

References 10 publications

Efficacy of Oral Prednisolone in Management of Bronchiolitis: A Placebo-Controlled Study

Efficacy of Oral Prednisolone in Management of Bronchiolitis: A Placebo-Controlled Study

Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review

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