Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial

Sureshkumar, Sathasivam; Omang, Agrawal; Anandhi, Amaranathan; B, Rajesh; Abdulbasith, K M; Vijayakumar, Chellappa; Chinnakali, Palanivel; Mohan, Pazhanivel; Kate, Vikram

doi:10.1007/s10620-020-06711-7

Cited by 14 publications

(4 citation statements)

References 23 publications

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“…methionine, selenium, β-carotene, ascorbic acid and α-tocopherol). Clinical trials on the simultaneous administration of pregabalin and antioxidants in patients with pain in the course of CP resulted in greater degree of pain reduction compared to those on pregabalin alone (Table 1) [12][13]. In another clinical trial, conducted on pediatric patients (average age 13 years), it was suggested that the administration of antioxidants (vitamin C, selenium) by itself reduces pain in 68% of patients [14].…”

Section: Resultsmentioning

confidence: 99%

Usage of pregabalin in the treatment of pain associated with chronic pancreatitis – a clinically oriented narrative review

Gałązka,

Skrzydło-Radomańska,

Kasztelan-Szczerbińska

et al. 2023

Eur J Trans Clin Med

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Abdominal pain is one of the main symptoms of pancreatic diseases, including chronic pancreatitis (CP). Once the disease is in remission, pain management is a key element of treatment. Co-analgesics may also be used at any stage of analgesia, among which antiepileptic drugs such as pregabalin. The first data on the beneficial effect of pregabalin on pain in the course of CP was published in a clinical trial in 2011, and it has been known since 2015 that the analgesic effect of pregabalin on CP has a different mechanism of action than conventional analgesics. Currently, research is focused on combining pregabalin with antioxidants and on methods to predict the patient's response to pregabalin administration. Based on current research, pregabalin appears to be a very useful agent for the pharmacologic treatment of pain in the setting of CP.

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Section: Resultsmentioning

confidence: 99%

Usage of pregabalin in the treatment of pain associated with chronic pancreatitis – a clinically oriented narrative review

Gałązka,

Skrzydło-Radomańska,

Kasztelan-Szczerbińska

et al. 2023

Eur J Trans Clin Med

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“… 51 Moreover, a prospective, double-blinded RCT from India in 2020 including a total of 90 patients with CP revealed that the combination of antioxidants and pregabalin could significantly reduce pain, requirement of non-opioid analgesics, and the number of hospital admissions, improving the overall satisfaction among patients. 52 However, more high-quality evidence is needed in the future as the efficacy and safety of pregabalin administration to CP patients in the short and long term are still unclear.…”

Section: Medicationmentioning

confidence: 99%

Management of chronic pancreatitis: recent advances and future prospects

Han,

Lv,

2024

Therap Adv Gastroenterol

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As a progressive fibroinflammatory disease, chronic pancreatitis (CP) often manifests as recurrent bouts of abdominal pain with or without complications, causing a heavy burden of health care. In recent years, some meaningful insights into the management of CP have been obtained from randomized controlled trials, systematic reviews, and meta-analyses, which were of great importance. Based on this research, it is shown that there are various treatments for CP. Therefore, it is of great importance to choose a suitable strategy for patients with CP individually. Relevant evidence on the management of CP was summarized in this review, including nutrition supplements, medication, endoscopy, surgery, exploration of novel therapies as well as evaluation and prediction of treatment response.

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“…[102,103] Antioxidant agents have been explored with little suggestion that they make a significant impact on CP pain; however, in a double-blind randomized controlled trial where antioxidants were combined with pregabalin, a significant reduction in pain, use of analgesics, and hospital admissions were seen in the treatment arm compared to placebo. [104] No analgesic agent is without potential side effects, [105] however, and so the composition and duration of a medical management approach in painful CP must be carefully assessed for each patient in a dynamic fashion throughout their disease course.…”

Section: Medical Treatment In Painful Cpmentioning

confidence: 99%

Recent advances in the understanding and management of chronic pancreatitis pain

Walker,

Babyok,

Saloman

et al. 2023

Journal of Pancreatology

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Abdominal pain is the most common symptom of chronic pancreatitis (CP), and is often debilitating for patients and very difficult to treat. To date, there exists no cure for the disease. Treatment strategies focus on symptom management and on mitigation of disease progression by reducing toxin exposure and avoiding recurrent inflammatory events. Traditional treatment protocols start with medical management followed by consideration of procedural or surgical intervention on selected patients with severe and persistent pain. The incorporation of adjuvant therapies to treat comorbidities including psychiatric disorders, exocrine pancreatic insufficiency, mineral bone disease, frailty, and malnutrition, are in their early stages. Recent clinical studies and animal models have been designed to improve investigation into the pathophysiology of CP pain, as well as to improve pain management. Despite the array of tools available, many therapeutic options for the management of CP pain provide incomplete relief. There still remains much to discover about the neural regulation of pancreas-related pain. In this review we will discuss research from the last five years that has provided new insights into novel methods of pain phenotyping and the pathophysiology of CP pain. These discoveries have led to improvements in patient selection for optimization of outcomes for both medical and procedural management, and identification of potential future therapies.

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Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial

Cited by 14 publications

References 23 publications

Usage of pregabalin in the treatment of pain associated with chronic pancreatitis – a clinically oriented narrative review

Usage of pregabalin in the treatment of pain associated with chronic pancreatitis – a clinically oriented narrative review

Management of chronic pancreatitis: recent advances and future prospects

Recent advances in the understanding and management of chronic pancreatitis pain

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