Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial

Noguera-González, Danny; Cerda-Cristerna, B.I.; Chavarría‐Bolaños, Daniel; Flores-Reyes, Héctor; Pozos‐Guillén, Amaury

doi:10.1111/iej.12099

Cited by 39 publications

(63 citation statements)

References 33 publications

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“…The contributory effect of premedication with ibuprofen on IANB success rates in treatment of teeth with irreversible pulpitis has been evaluated in several previous studies 1, [13][14][15]21) . The primary function of ibuprofen is blocking the ongoing production of PGs 7) .…”

Section: Discussionmentioning

confidence: 99%

“…The primary function of ibuprofen is blocking the ongoing production of PGs 7) . Parirokh et al 15) and NogueraGonzalez et al 13) reported that premedication with ibuprofen significantly improved the success rates of IANB. The present results are in agreement with those of these earlier reports.…”

Section: Discussionmentioning

confidence: 99%

“…931223). The sample size was calculated with a type I error of 0.05 and statistical power of 80% on the basis of a previous report 13) . Seventy-eight adult patients participated in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the chemical inflammatory mediators that activate or sensitize peripheral nociceptors 7) . Investigations into the effect of premedication with NSAIDs on the success rate of IANB have been conducted, but have yielded contradictory results 1,[13][14][15]21) . Glucocorticoids are another class of drugs that prevent the production or release of inflammatory mediators.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

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Mortazavi

Forghani

et al. 2017

Bull. Tokyo Dent. Coll.

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The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect of preoperative oral administration of ibuprofen or dexamethasone on the success rate of inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. Seventy-eight patients with irreversible pulpitis were randomly divided into 3 groups (26 per group) and given one of the following at 1 hr prior to performing local anesthesia: a placebo; 400 mg ibuprofen; or 4 mg dexamethasone. Each patient recorded their pain level on a visual analog scale before taking the medication or placebo, at 15 min after completion of IANB, and during treatment if pain occurred. The success of the anesthesia was defined as no or mild pain at any stage during the endodontic procedure. The success rate of the IANB was 38.5, 73.1, and 80.8% with the placebo, ibuprofen, and dexamethasone, respectively. Both ibuprofen and dexamethasone were significantly more effective than the placebo. No significant difference was observed, however, between the two experimental medications in terms of effectiveness. The results of the present study suggest that premedication with ibuprofen or dexamethasone increases the success rate of an IANB in patients with symptomatic irreversible pulpitis in the mandibular molars.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Bidar

Mortazavi

Forghani

et al. 2017

Bull. Tokyo Dent. Coll.

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“…For cases of preoperatory pain (especially in endodontic pathologies or after trauma), preventive analgesia may be helpful to control transoperatory pain and to increase the success and duration of anesthetic blockade (8). The other advantages such as less postoperatory pain and analgesics requeriments are also expected.…”

Section: Preventive Dental Analgesia: Evidence Based-approachmentioning

confidence: 99%

Preventive Analgesia: An Evidence-Based Alternative for Dentistry

Chavarría‐Bolaños

Esparza-Villalpando

2017

Odovtos - Int J Dent Sc

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The effective management of pain in dentistry increases the patient satisfaction, improves the treatment outcome and reduces the cost of care. To achieve this goal, different strategies are available for the administration of analgesics, such as preventive analgesia. The aim of this approach is to minimize sensitization induced by noxious perioperatory stimuli (both pre, intra and postoperatory). Available research support the favorable effect of preventive analgesia, although it also recognizes an important lack of high quality evidence to confirm its advantages. This new perspective article summarizes the preventive analgesia protocol, and its potential use in dentistry. KEYWORDSPreventive analgesia; Analgesics; Pain management; Dental pain. RESUMENEl manejo eficaz del dolor en odontología aumenta la satisfacción del paciente, mejora los resultados del tratamiento y reduce el costo de la atención. Para alcanzar esta meta, existen diferentes estrategias en la administración de analgésicos, como la analgesia preventiva. El objetivo de este enfoque es minimizar la sensibilización inducida por los estímulos perioperatorios nocivos (tanto pre, intra y postoperatorios). Los estudios apoyan el efecto favorable de la analgesia preventiva, aunque también reconocen una importante carencia de evidencia de alta calidad para confirmar sus ventajas. Este artículo de nueva perspectiva resume el enfoque de la analgesia preventiva y su potencial uso en odontología. PALABRAS CLAVEAnalgesia preventiva; Analgésicos; Manejo del dolor; Dolor dental.

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Non‐surgical Root Canal Treatment Case IV

Chavarría‐Bolaños

Masuoka²,

Pozos‐Guillén

2018

Clinical Cases in Endodontics

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Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial

Abstract: Preoperative oral administration of IBU significantly improved the efficacy of IANB in patients with symptomatic irreversible pulpitis.

Cited by 39 publications

References 33 publications

Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Preventive Analgesia: An Evidence-Based Alternative for Dentistry

Non‐surgical Root Canal Treatment Case IV

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