Efficacy of Primary Surgical Versus Medical Intervention for Treatment of Left-Sided Infective Endocarditis

Gatzoflias, Stergios; Beier, Matthew A; Ning, Yuming; Kossar, Alexander P.; Gailes, Marcia; Guaman, Karina; Segall, Michal; Wang, Catherine; Takeda, Koji; Takayama, Hiroo; Bapat, Vinayak; Naka, Yoshifumi; Argenziano, Michael; Smith, Craig R.; Gordon, Rachel; Gutierrez, José; Kurlansky, Paul; George, Isaac

doi:10.1016/j.athoracsur.2020.03.047

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…To account for immortal time bias as a result of inappropriate accounting of follow-up time and treatment status, an exploratory analysis was added using similar analytic methods reported in previous studies. (55,56) Figure 6 shows the results of the analysis. Imbalance of pretreatment confounders between the patients who underwent R0 resection and those who received no or other treatments were adjusted by inverse probability of treatment weighting using propensity scores estimated by a pooled logistic regression model.…”

Section: Does Conversion Surgery Truly Improve the Survival In Patients With Advanced Hcc?mentioning

confidence: 99%

Multidisciplinary Approach to the Treatment of Advanced Hepatocellular Carcinoma in the Era of New Biologic Agents

Shindoh

2022

J Nippon Med Sch

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With the recent advances in the field of systemic therapy, an increasing number of patients with advanced hepatocellular carcinoma (HCC) are expected to benefit from surgery.However, given the complex background of the disease and frequent presence of underlying liver injury, treatment of advanced HCC is rather complex and the treatment principle applied to colorectal liver metastases, for which conversion surgery has been actively performed, is often not applicable to patients with HCC. To maximize the survival outcomes of patients with HCC, optimization of each step of treatment through a multidisciplinary approach is inevitable. As the initial treatment, systematic removal of the tumor-bearing portal territory is associated with improved survival in patients with solitary HCC, and radiofrequency ablation is also effective for small, oligo HCCs. Although the high incidence of recurrence even after curative-intent treatment is a major issue in HCC, aggressive treatment for recurrence is also important, because a prolonged cancer-free interval is reported to be associated with improved overall survival. For patients with advanced disease, recently introduced molecular-targeted agents may potentially be effective for successful conversion to surgery in initially unresectable cases, although the overall response rate of HCC to systemic therapies remains unsatisfactory as compared to that of colorectal liver metastases. In this report, the theoretical bases for the management of HCC are revisited and the currently used strategies to maximize the survival outcomes in patients with advanced HCC is discussed..

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Section: Does Conversion Surgery Truly Improve the Survival In Patients With Advanced Hcc?mentioning

confidence: 99%

Multidisciplinary Approach to the Treatment of Advanced Hepatocellular Carcinoma in the Era of New Biologic Agents

Shindoh

2022

J Nippon Med Sch

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Variables That Account for the Heterogeneity in Left-Sided Infective Endocarditis

Weininger¹,

Mori²,

Geirsson³

2021

The Annals of Thoracic Surgery

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Rationale for Inverse Probability Treatment Weight Variables in Left-Sided Infective Endocarditis Patients Treated With Primary Surgical or Medical Therapy

Gatzoflias

Kurlansky

George

2021

The Annals of Thoracic Surgery

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Efficacy of Primary Surgical Versus Medical Intervention for Treatment of Left-Sided Infective Endocarditis

Cited by 5 publications

References 17 publications

Multidisciplinary Approach to the Treatment of Advanced Hepatocellular Carcinoma in the Era of New Biologic Agents

Multidisciplinary Approach to the Treatment of Advanced Hepatocellular Carcinoma in the Era of New Biologic Agents

Variables That Account for the Heterogeneity in Left-Sided Infective Endocarditis

Rationale for Inverse Probability Treatment Weight Variables in Left-Sided Infective Endocarditis Patients Treated With Primary Surgical or Medical Therapy

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