2022
DOI: 10.7759/cureus.20990
|View full text |Cite
|
Sign up to set email alerts
|

Efficacy of Pro-Kinetic Agents in Type 2 Diabetes Mellitus Patients With Gastroparesis Using Lactulose Hydrogen Breath Testing: A Randomized Trial

Abstract: The aim of the study was to determine the efficacy of prokinetic agents in diabetic gastroparesis patients. MethodThis was a randomized open-label trial conducted on 50 patients with type 2 diabetes experiencing diabetic gastroparesis, which was diagnosed with the lactulose hydrogen breath test. After randomization, all 50 patients were divided into four arms (cinitapride, metoclopramide, levosulpiride, and domperidone) of different prokinetics and followed up for four weeks; after which, repeat gastroparesis … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
1
0
2

Year Published

2022
2022
2022
2022

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(3 citation statements)
references
References 22 publications
0
1
0
2
Order By: Relevance
“…Based on anecdotal reports, subcutaneous metoclopramide may be effective in treating vomiting episodes. Other D2 receptor antagonists, including domperidone, may improve symptoms to a comparable extent to metoclopramide [ 70 ]. Tardive dyskinesia (more common with metoclopramide than domperidone) and QTc (corrected QT interval) prolongation with the potential for arrhythmia are important concerns, although the risk of tardive dyskinesia may be as low as 0.1% per 1000 patient-years with metoclopramide [ 71 ].…”
Section: Management Of Gastroparesis Associated With Upper Gastrointe...mentioning
confidence: 99%
“…Based on anecdotal reports, subcutaneous metoclopramide may be effective in treating vomiting episodes. Other D2 receptor antagonists, including domperidone, may improve symptoms to a comparable extent to metoclopramide [ 70 ]. Tardive dyskinesia (more common with metoclopramide than domperidone) and QTc (corrected QT interval) prolongation with the potential for arrhythmia are important concerns, although the risk of tardive dyskinesia may be as low as 0.1% per 1000 patient-years with metoclopramide [ 71 ].…”
Section: Management Of Gastroparesis Associated With Upper Gastrointe...mentioning
confidence: 99%
“…El padecer de neuropatía autonómica gastrointestinal secundaria a la diabetes mellitus, como es la gastroparesia, también conlleva sus propias complicaciones, siendo una de ellas la disbiosis intestinal, pues se ha comprobado que aquellos que sufren esta complicación de la diabetes poseen una microbiota intestinal caracterizada por Fusobacteria, Lachnoclostridium, Fusobacterium_mortiferum, entre otros, a diferencia de los Bacteroidetes, Firmicutes y Proteobacteria que poseen las personas sanas (19). En casos severos la gastroparesia diabética puede llevar al paciente a sufrir malnutrición, deshidratación e incluso desequilibrios hidroelectrolíticos (20).…”
Section: Manifestaciones Clínicasunclassified
“…Entre estos fármacos se encuentran la metoclopramida, domperidona, cisapride (12), así como itopride y trimebutina, pero su uso se recomienda únicamente a corto plazo (3). De ellos se ha afirmado que no existe diferencia significativa entre los efectos positivos causados por el uso de metoclopramida, cinitaprida, levosulpirida y domperidona, al ser estos valorados por la escala de puntajes de síntomas cardinales de gastroparesia y el tiempo de tránsito orocecal (20), sin embargo, hay que considerar sus mecanismos de acción y efectos adversos antes de su prescripción.…”
Section: Procinéticosunclassified