Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy

Alkimaviciene, Evelina; Pušinskaitė, Rasa; Basevičienė, Nomeda; Banienė, Rasa; Savickienė, Nijolė; Pacauskienė, Ingrida Marija

doi:10.1016/j.identj.2022.08.006

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…Moreover, MMP-3 concentration in saliva was increased when PAC was incorporated, compared with MINST alone. These results indicated that MMP-3 concentration in saliva can be used as a biomarker for the assessment of periodontal health [94]. Additionally, a prospective, double-blind, randomized clinical trial conducted by Sánchez et al also identified that oligomeric PAC can affect the condition of periodontal tissue [95].…”

Section: Polyphenols and Periodontal Diseasesmentioning

confidence: 95%

Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

Guo,

Li,

Chen

et al. 2023

Nutrients

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Polyphenols, a class of bioactive compounds with phenolic structures, are abundant in human diets. They have gained attention in biomedical fields due to their beneficial properties, including antioxidant, antibacterial, and anti-inflammatory activities. Therefore, polyphenols can prevent multiple chronic or infectious diseases and may help in the prevention of oral diseases. Oral health is crucial to our well-being, and maintaining a healthy oral microbiome is essential for preventing various dental and systemic diseases. However, the mechanisms by which polyphenols modulate the oral microbiota and contribute to oral health are still not fully understood, and the application of polyphenol products lies in different stages. This review provides a comprehensive overview of the advancements in understanding polyphenols’ effects on oral health: dental caries, periodontal diseases, halitosis, and oral cancer. The mechanisms underlying the preventive and therapeutic effects of polyphenols derived from dietary sources are discussed, and new findings from animal models and clinical trials are included, highlighting the latest achievements. Given the great application potential of these natural compounds, novel approaches to dietary interventions and oral disease treatments may emerge. Moreover, investigating polyphenols combined with different materials presents promising opportunities for developing innovative therapeutic strategies in the treatment of oral diseases.

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Section: Polyphenols and Periodontal Diseasesmentioning

confidence: 95%

Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

Guo,

Li,

Chen

et al. 2023

Nutrients

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“…For the degradation experiments, three-dimensional fibre matrix of PLGA/(R,S)-PHB, with and without proanthocyanidins were incubated at 37 • C (± 0.5 • C) in screw-capped vials with an air-tight PTFE/silicone septum containing 10 mL of demineralized water (pH = 6.1) The solid samples of electrospun mats were withdrawn from the test environment after specific time intervals, specifically 1, 3,5,7,9,11,15,19,23,27,31,35,39,43,47,51,55,65,71, and 85 days. The incubation of the samples was run in triplicate.…”

Section: Hydrolytic Degradation Under Laboratory Conditionmentioning

confidence: 99%

“…Proanthocyanidins (PCANs) are oligomers or polymers of monomeric flavan-3-ols produced as an end-product of the flavonoid biosynthetic pathway [ 19 , 20 , 21 ]. PCANs exhibit antioxidant, anti-inflammatory, cytoprotective, and antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters

Zięba,

Sikorska,

Musioł

et al. 2023

IJMS

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Delivery systems for biologically active substances such as proanthocyanidins (PCANs), produced in the form of electrospun nonwoven through the electrospinning method, were designed using a polymeric blend of poly(L-lactide-co-glycolide) (PLGA)and poly[(R,S)-3-hydroxybutyrate] ((R,S)-PHB). The studies involved the structural and thermal characteristics of the developed electrospun three-dimensional fibre matrices unloaded and loaded with PCANs. In the next step, the hydrolytic degradation tests of these systems were performed. The release profile of PCANs from the electrospun nonwoven was determined with the aid of UV–VIS spectroscopy. Approximately 30% of the PCANs were released from the tested electrospun nonwoven during the initial 15–20 days of incubation. The chemical structure of water-soluble oligomers that were formed after the hydrolytic degradation of the developed delivery system was identified through electrospray ionization mass spectrometry. Oligomers of lactic acid and OLAGA oligocopolyester, as well as oligo-3-hydroxybutyrate terminated with hydroxyl and carboxyl end groups, were recognized as degradation products released into the water during the incubation time. It was also demonstrated that variations in the degradation rate of individual mat components influenced the degradation pattern and the number of formed oligomers. The obtained results suggest that the incorporation of proanthocyanidins into the system slowed down the hydrolytic degradation process of the poly(L-lactide-co-glycolide)/poly[(R,S)-3-hydroxybutyrate] three-dimensional fibre matrix. In addition, in vitro cytotoxicity and antimicrobial studies advocate the use of PCANs for biomedical applications with promising antimicrobial activity.

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The relationship of dietary flavonoids and periodontitis in US population: a cross-sectional NHANES analysis

Liu,

Yin,

et al. 2024

Clin Oral Invest

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Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy

Cited by 5 publications

References 48 publications

Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters

The relationship of dietary flavonoids and periodontitis in US population: a cross-sectional NHANES analysis

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