Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta‐analysis based on randomized controlled trials

Zhang, Ning; Zhang, Yanan; Li, Menglin; Wang, Weiguang; Liu, Zhenzhu; Xi, Chongcheng; Huang, Xingguo; Liu, Jintao; Huang, Jun; Tian, Dong; Mu, Jie; Liao, Xing; Zhai, Shengli

doi:10.1002/brb3.1699

Cited by 47 publications

(41 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…demonstrated that psychological distress increased coronavirus infections in healthy subjects who were inoculated with either one of five respiratory viruses including coronavirus‐type 229E through nasal drops. Gut dysbiosis is well known to exist in chronically stressed individuals, 53 and probiotics have been used to relieve stress in clinical trials 54 …”

Section: Dysregulation Of the Intestinal Microbiota In Covid‐19mentioning

confidence: 99%

Altered gut microbial metabolites could mediate the effects of risk factors in Covid‐19

Chen¹,

Hall²,

Vitetta

2021

Reviews in Medical Virology

View full text Add to dashboard Cite

Summary Coronavirus disease 2019 (Covid‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, is now pandemic. While most Covid‐19 patients will experience mild symptoms, a small proportion will develop severe disease, which could be fatal. Clinically, Covid‐19 patients manifest fever with dry cough, fatigue and dyspnoea, and in severe cases develop into acute respiratory distress syndrome (ARDS), sepsis and multi‐organ failure. These severe patients are characterized by hyperinflammation with highly increased pro‐inflammatory cytokines including IL‐6, IL‐17 and TNF‐alpha as well as C‐reactive protein, which are accompanied by decreased lymphocyte counts. Clinical evidence supports that gut microbiota dysregulation is common in Covid‐19 and plays a key role in the pathogenesis of Covid‐19. In this narrative review, we summarize the roles of intestinal dysbiosis in Covid‐19 pathogenesis and posit that the associated mechanisms are being mediated by gut bacterial metabolites. Based on this premise, we propose possible clinical implications. Various risk factors could be causal for severe Covid‐19, and these include advanced age, concomitant chronic disease, SARS‐CoV‐2 infection of enterocytes, use of antibiotics and psychological distress. Gut dysbiosis is associated with risk factors and severe Covid‐19 due to decreased commensal microbial metabolites, which cause reduced anti‐inflammatory mechanisms and chronic low‐grade inflammation. The preconditioned immune dysregulation enables SARS‐CoV‐2 infection to progress to an uncontrolled hyperinflammatory response. Thus, a pre‐existing gut microbiota that is diverse and abundant could be beneficial for the prevention of severe Covid‐19, and supplementation with commensal microbial metabolites may facilitate and augment the treatment of severe Covid‐19.

show abstract

Section: Dysregulation Of the Intestinal Microbiota In Covid‐19mentioning

confidence: 99%

Altered gut microbial metabolites could mediate the effects of risk factors in Covid‐19

Chen¹,

Hall²,

Vitetta

2021

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…Supplementation with Lactobacillus reuteri reduced stress-induced anxiety-like behaviours 30 and restored disturbed social behaviour in mice with an unbalanced gut microbiota 31 . Meta-analyses also suggest that probiotic supplementation in humans can reduce subjective stress levels without altering cortisol levels 32 and has antidepressant and anxiolytic effects 33 . One possible pathway by which Lactobacillus may influence the behaviour of its host is through the production of neurochemicals similar to those produced in vertebrate organisms 34 .…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Lactobacillus early in life alters attention bias to threat in piglets

Verbeek

Dicksved

Keeling

2021

Sci Rep

View full text Add to dashboard Cite

Gut microbes play an important role in regulating brain processes and influence behaviour, cognition and emotional states in humans and rodents. Nevertheless, it is not known how ingestion of beneficial microbes modulates emotional states in piglets and whether it can improve welfare. Here we use an attention bias task to assess the effects of Lactobacillus reuteri ATCC-PTA-6475 and Lactobacillus plantarum L1-6 supplementation early in life on emotional states in 33 piglets compared to 31 placebo supplemented piglets. We hypothesized that Lactobacillus supplementation would reduce vigilance behaviour (head at shoulder height or higher) and attention (head oriented towards the threat) in response to an auditory threat. The results showed that the control group increased vigilance behaviour in response to the threat, but there was no increase in the probiotics group. Despite the increased vigilance, the control group paid less attention to the threat. One explanation may be that control piglets avoided looking in the direction of the threat just because they perceived it as more threatening, but further research is necessary to confirm this. In conclusion, Lactobacillus supplementation may be a suitable tool to reduce anxiety, promote a more appropriate response to a challenge and so improve welfare.

show abstract

“…Conversely, a systematic review and meta-analysis of RCTs including 1146 volunteers revealed that probiotics can mitigate subjective stress, but more evidence from clinical trials is needed to confirm these results [52].…”

Section: Probioticsmentioning

confidence: 99%

Nutrition, Exercise, and Stress Management for Treatment and Prevention of Psychiatric Disorders. A Narrative Review Psychoneuroendocrineimmunology-Based

Bottaccioli

Marzola

et al. 2021

Endocrines

View full text Add to dashboard Cite

Psychoneuroendocrineimmunology (PNEI) brings together knowledge acquired since the 1930s from endocrinology, immunology, neuroscience, and psychology. With PNEI, a model of research and interpretation of health and disease is emerging, which sees the human body as a structured and interconnected unit, where the psychological and biological systems are mutually coordinated. In the PNEI view, many factors could influence mental health, with the endocrine system involved in mediating the effects of environmental stress on mental health and inflammation in the onset and course of psychiatric disorders as a result of individual and collective conditions and behaviors. Among these, nutrition is one way by which the environment impacts physiology: indeed, many pieces of research showed that several elements (e.g., probiotics, fish oil, zinc) have a positive effect on mental disorders thus being potentially augmentation agents in treatment. Still, physical activity can moderate depressive symptoms, while prolonged stress increases the risk of psychopathology. Taken together, the PNEI-based approach may inform prevention and treatment strategies, also in the field of mental health care.

show abstract

Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta‐analysis based on randomized controlled trials

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 47 publications

References 84 publications

Altered gut microbial metabolites could mediate the effects of risk factors in Covid‐19

Altered gut microbial metabolites could mediate the effects of risk factors in Covid‐19

Supplementation of Lactobacillus early in life alters attention bias to threat in piglets

Nutrition, Exercise, and Stress Management for Treatment and Prevention of Psychiatric Disorders. A Narrative Review Psychoneuroendocrineimmunology-Based

Contact Info

Product

Resources

About