Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

Nagase, Nozomi; Ikeda, Yuka; Tsuji, Akira; Matsuda, Satoru

doi:10.4239/wjd.v13.i3.150

Cited by 15 publications

(16 citation statements)

References 99 publications

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“…These are mediated by the presence of specific enzyme gene clusters [ 131 , 132 , 133 , 134 , 135 ]. Fecal microbiota transplantation (FMT) is another newly emerging form of microbiome modulation that has the potential to restore intestinal structure, ameliorate inflammation, and serve therapeutically in diabetes [ 136 ]. FMT from healthy donors has been shown to improve podocyte-involved glomerular injury in experimental studies with diabetic rats, in a process mediated by restoration of the AMPKα activity [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

Renal Health Improvement in Diabetes through Microbiome Modulation of the Gut–Kidney Axis with Biotics: A Systematic and Narrative Review of Randomized Controlled Trials

Paul

Kaul

Châari

2022

IJMS

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Diabetes mellitus is the most common endocrine disorder worldwide, with over 20% of patients ultimately developing diabetic kidney disease (DKD), a complex nephropathic complication that is a leading cause of end-stage renal disease. Various clinical trials have utilized probiotics, prebiotics, and synbiotics to attempt to positively modulate the gut microbiome via the gut–kidney axis, but consensus is limited. We conducted a multi-database systematic review to investigate the effect of probiotics, prebiotics, and synbiotics on various biomarkers of renal health in diabetes, based on studies published through 10 April 2022. Adhering to the Cochrane Collaboration and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, relevant articles were systematically screened and extracted by independent reviewers; subsequently, results were systematically compiled, analyzed, and expanded through a narrative discussion. A total of 16 publications encompassing 903 diabetic individuals met the inclusion criteria. Our findings show that some studies report statistically significant changes in common renal markers, such as serum creatinine, estimated glomerular filtration rate, blood urea nitrogen/urea, microalbuminuria, and uric acid, but not on serum albumin, sodium, potassium, phosphorous, or total urine protein. Interestingly, these nutraceuticals seem to increase serum uric acid concentrations, an inflammatory marker usually associated with decreased renal health. We found that probiotics from the Lactobacillus and Bifidobacterium families were the most investigated, followed by Streptococcus thermophilus. Prebiotics including inulin, galacto-oligosaccharide, and resistant dextrin were also examined. The single-species probiotic soymilk formulation of Lactobacillus plantarum A7 possessed effects on multiple renal biomarkers in DKD patients without adverse events. We further investigated the optimum nutraceutical formulation, discussed findings from prior studies, described the gut–kidney axis in diabetes and DKD, and finally commented on some possible mechanisms of action of these nutraceuticals on renal health in diabetics. Although probiotics, prebiotics, and synbiotics have shown some potential in ameliorating renal health degradation in diabetes via gut–kidney axis crosstalk, larger and more convincing trials with focused objectives and next-generation nutraceutical formulations are required to investigate their possible role as adjunct therapy in such patients.

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Section: Discussionmentioning

confidence: 99%

Renal Health Improvement in Diabetes through Microbiome Modulation of the Gut–Kidney Axis with Biotics: A Systematic and Narrative Review of Randomized Controlled Trials

Paul

Kaul

Châari

2022

IJMS

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“…The human body made‐up of various microbial cells and bacteria; and majorly part found in the gut (Nagase et al, 2022). The microbiota is a complex community of more than 100 trillion bacteria/cells in the human intestine that helps to protect the kidney, but gut dysbiosis may make renal dysfunction worse (De Sordi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The carbohydrate was converted by the gut bacteria into oligosaccharides and monosaccharides, which can then be fermented into short‐chain fatty acids (SCFAs). SCFAs are the most critical end products of gut fermentation, with implications for host physiology (Nagase et al, 2022). SCFAs play a crucial role between the host and gut microbiota and it also have preventive effect on renal function of chronic kidney disease (CKD) patients.…”

Section: Discussionmentioning

confidence: 99%

Nephro‐protective effect of Daphnetin in hyperoxaluria‐induced rat renal injury via alterations of the gut microbiota

Zhou

Wen

Gong

et al. 2022

Journal of Food Biochemistry

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It is well proved that hyperoxaluria induces the renal injury and finally causes the end stage kidney disease. Daphnetin (coumarin derivative) already confirmed renal protective effect in renal model, but hyperoxaluria protective effect still unexplore. The objective of this research was to scrutinize the renal protective effect of daphnetin against ethylene glycol (GC)‐induced hyperoxaluria via altering the gut microbiota. GC (1% v/v) was used for the induction of hyperoxaluria in the rats and the rats were received the oral administration of daphnetin (5, 10 and 15 mg/kg). The body and renal weight were assessed. Urine, renal, inflammatory cytokines, antioxidant, inflammatory parameters, and gut microbiota were appraised. Daphnetin effectually improved the body weight and reduced the renal weight. Its also remarkably boosted the magnesium, calcium, citrate level and suppressed the level of uric acid and oxalate formation. Daphnetin significantly (p < .001) ameliorate the level of urinary kidney injury molecule 1 (KIM‐1), blood urea nitrogen (BUN), urea, serum creatinine (Scr), neutrophil gelatinase‐associated lipocalin (NGAL) and uric acid along with inflammatory cytokines and inflammatory mediators. Daphnetin considerably repressed the malonaldehyde (MDA) level, protein carbonyl and improved the level of glutathione reductase (GR), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT). Daphnetin treatment considerably altered the microbial composition of different bacteria at phylum, genus and family level. Daphnetin significantly suppressed the Firmicutes relative abundance and boosted the Bacteroidetes relative abundance. Our result clearly indicated that daphnetin remarkably ameliorates the GC induced hyperoxaluria in rats via altering the oxidative stress, inflammatory reaction and gut microbiota. Practical application Nephrotoxicity is a serious health disease worldwide. We induce the renal toxicity in the experimental rats using the ethylene glycol and scrutinized the renal protective effect of daphnetin. Daphnetin considerably suppress the renal, urine parameters. For estimation the underlying mechanism, we estimated the gut microbiota in all group rats. Daphnetin remarkably altered the level of gut microbiota and suggesting the renal protective effect.

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“…The pathogenic role of the gut-kidney axis in the development of chronic kidney disease is also associated with chronic fatty liver disease [47]. Altering the levels of short-chain fatty acids, D-amino acids, and ROS biosynthesis in the gut can influence the pathogenesis of nephrotoxicity [48]. The microbiota associated with the gut-kidney axis plays a key role in the development and/or prevention of diabetic nephropathy [48].…”

Section: Favorable Roles Of the Gut-kidney Axis For The Protection Of...mentioning

confidence: 99%

“…Altering the levels of short-chain fatty acids, D-amino acids, and ROS biosynthesis in the gut can influence the pathogenesis of nephrotoxicity [48]. The microbiota associated with the gut-kidney axis plays a key role in the development and/or prevention of diabetic nephropathy [48]. This suggests that the gut microbiota is involved in the nephrotoxicity of GVHD and/or the use of cyclosporine.…”

Section: Favorable Roles Of the Gut-kidney Axis For The Protection Of...mentioning

confidence: 99%

Promising Tactics with Certain Probiotics for the Treatment of Nephropathy in Hematopoietic Stem Cell Transplantation

Taniguchi¹,

Sawamura²,

Ikeda³

et al. 2022

OBM Transplant

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Hematopoietic stem cell transplantation (HSCT) is a standard form of cellular therapy for patients suffering from malignant hematological diseases. However, graft-versus-host disease (GVHD) is a very serious complication and a major cause of morbidity and mortality after allogeneic HSCT. Calcineurin inhibitors, such as cyclosporine, are widely used to enhance the survival of patients who have undergone HSCT. Unfortunately, both GVHD and cyclosporine occasionally cause nephropathy. Several studies have shown that the gut-kidney axis is associated with nephropathy. Dysbiosis of the gut microbiota might aggravate renal damage by increasing systemic micro-inflammation, suggesting that diet might affect the risk of GVHD. Here, we summarized the recent findings regarding the association between the alteration of gut microbiota and nephrotoxicity. The results suggested that treatment with certain probiotics benefits the symbiosis in the gut-kidney axis and makes HSCT safer.

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Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

Cited by 15 publications

References 99 publications

Renal Health Improvement in Diabetes through Microbiome Modulation of the Gut–Kidney Axis with Biotics: A Systematic and Narrative Review of Randomized Controlled Trials

Renal Health Improvement in Diabetes through Microbiome Modulation of the Gut–Kidney Axis with Biotics: A Systematic and Narrative Review of Randomized Controlled Trials

Nephro‐protective effect of Daphnetin in hyperoxaluria‐induced rat renal injury via alterations of the gut microbiota

Promising Tactics with Certain Probiotics for the Treatment of Nephropathy in Hematopoietic Stem Cell Transplantation

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